PMID- 32322430
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 2093-6966 (Print)
IS  - 2234-6856 (Electronic)
IS  - 2093-6966 (Linking)
VI  - 23
IP  - 1
DP  - 2020 Mar 31
TI  - External Application of Herbal Medicines for Acne Vulgaris: A Systematic Review 
      and Meta Analysis.
PG  - 8-17
LID - 10.3831/KPI.2020.23.002 [doi]
AB  - AIM OF THE STUDY: The objective of this systematic review is to critically 
      evaluate the evidence of the effectiveness and safety of external application of 
      herbal medicines (EAHM) for acne vurgalis (AV). METHODS: English, Chinese and 
      Korean language databases were searched up to May 2018. Randomized clinical 
      trials (RCTs) that reported the effects of EAHM for AV were included and 
      analysed. RESULTS: A total of 10 randomized trials with 656 AV patients were 
      identified. A meta-analysis of two RCTs indicated that EAHM had a significant 
      effect on improving primary outcome 'global assessment' compared with placebo 
      (mean difference (MD) = -2.62, confidence interval (CI) = -4.84 to -0.40, p = 
      0.02). Furthermore, data extracted from two RCTs showed that EAHM significantly 
      reduce primary outcome 'inflammatory lesion count of acne' (MD = -1.25, CI = 
      -1.68 to -0.83, p < 0.00001) and 'non-inflammatory lesion count of acne' (MD = 
      -1.32, CI = -1.75 to -0.90, p < 0.00001). No significant difference was observed 
      between groups in secondary outcome 'sebum of skin' (MD = -0.21, CI = -0.53 to 
      0.11, p = 0.20) and 'patient-reported changes in symptom' (relative risk (RR) = 
      2.56, CI = 0.43 to 15.22, p = 0.30). No severe adverse events (AEs) were found 
      and no treatment was stopped due to AEs of EAHM. CONCLUSIONS: EAHM seems to have 
      affirmative effects, but quality of evidence, and non-standardized use of EAHM 
      make our conclusion weak. Our suggestion is rigorously designed RCTs and 
      standardization of EAHM are required in the future.
CI  - (c) 2020 Korean Pharmacopuncture Institute.
FAU - Sung, Soo-Hyun
AU  - Sung SH
AUID- ORCID: 0000-0001-7606-0147
AD  - Department of Policy Development, National Development Institute of Korean 
      Medicine, Seoul, 04554, South Korea.
FAU - Choi, Gwang-Ho
AU  - Choi GH
AUID- ORCID: 0000-0001-6443-5941
AD  - School of Korean Medicine, Pusan National University, Yangsan, 50612, South 
      Korea.
FAU - Lee, Nam-Woo
AU  - Lee NW
AUID- ORCID: 0000-0002-2662-5944
AD  - School of Korean Medicine, Pusan National University, Yangsan, 50612, South 
      Korea.
FAU - Shin, Byung-Cheul
AU  - Shin BC
AUID- ORCID: 0000-0002-0059-2689
AD  - Division of Clinical Me dicine, School of Korean Medicine, Pusan National 
      University, Yangsan, 50612, South Korea.
LA  - eng
PT  - Systematic Review
PL  - Korea (South)
TA  - J Pharmacopuncture
JT  - Journal of pharmacopuncture
JID - 101572812
PMC - PMC7163391
OTO - NOTNLM
OT  - acne vulgaris
OT  - external application
OT  - herbal medicine
OT  - meta-analysis
OT  - randomized controlled trial
OT  - systematic review
COIS- Conflicts of interest The authors declare that there are no conflicts of interest 
      regarding the publication of this paper.
EDAT- 2020/04/24 06:00
MHDA- 2020/04/24 06:01
PMCR- 2020/03/31
CRDT- 2020/04/24 06:00
PHST- 2019/10/01 00:00 [received]
PHST- 2020/01/03 00:00 [revised]
PHST- 2020/01/22 00:00 [accepted]
PHST- 2020/04/24 06:00 [entrez]
PHST- 2020/04/24 06:00 [pubmed]
PHST- 2020/04/24 06:01 [medline]
PHST- 2020/03/31 00:00 [pmc-release]
AID - 2093-6966-v23-n01-008 [pii]
AID - 10.3831/KPI.2020.23.002 [doi]
PST - ppublish
SO  - J Pharmacopuncture. 2020 Mar 31;23(1):8-17. doi: 10.3831/KPI.2020.23.002.