PMID- 32322781
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 2472-4971 (Print)
IS  - 2472-4971 (Electronic)
IS  - 2472-4971 (Linking)
VI  - 4
IP  - 1
DP  - 2019
TI  - Peritoneal Carcinomatosis in Well-Differentiated Small-Intestinal Neuroendocrine 
      Tumors with Mesenteric Tumor Deposits.
PG  - 1-10
AB  - OBJECTIVE: Well-differentiated small-intestinal neuroendocrine tumors (SI-NETs) 
      tend to be biologically indolent. Despite this tendency, they have a predilection 
      for metastasis. Peritoneal involvement is quite common as is unfortunately 
      peritoneal carcinomatosis (PC). PC is a dreaded metastatic complication due to 
      the significant morbidity it creates for patients as well as well as increasing 
      their mortality risk. The risk factors for PC development in SI-NETs remain 
      understudied; however, one such factor may be the presence of mesenteric tumor 
      deposits (MTDs). METHODS: We performed a retrospective analysis on 208 
      well-differentiated SI-NET patient samples, the majority with mesenteric masses, 
      from the pathology archives of Vanderbilt University Medical Center. We sought to 
      explore whether MTD presence was associated with PC, what other patient 
      determinants were associated with PC and prognostic implication of these 
      determinants. RESULTS: Patients with MTDs had an OR of 3.9 (CI 1.6, 10.9) for PC 
      compared to patients without MTDs in the analysis. Patients who developed PC 
      fared more poorly than those who did not (p=0.044). CONCLUSION: Our analysis, to 
      the best of our knowledge, is the first to demonstrate an association between MTD 
      presence and PC in this patient subgroup. We believe this finding warrants 
      prospective evaluation given the possible therapeutic implications of being able 
      to stratify SI-NET patients by their risk for developing PC based upon MTD 
      presence.
FAU - Das, Satya
AU  - Das S
AD  - Department of Internal Medicine, Division of Hematology and Oncology, Vanderbilt 
      University Medical Center, Nashville, Tennessee, USA.
FAU - Shi, Chanjuan
AU  - Shi C
AD  - Department of Pathology, Microbiology and Immunology, Vanderbilt University 
      Medical Center, Nashville, Tennessee, USA.
FAU - Koyama, Tatsuki
AU  - Koyama T
AD  - Division of Biostatistics, Vanderbilt University School of Medicine, Nashville, 
      Tennessee, USA.
FAU - Huang, Yi
AU  - Huang Y
AD  - Division of Biostatistics, Vanderbilt University School of Medicine, Nashville, 
      Tennessee, USA.
FAU - Gonzalez, Raul
AU  - Gonzalez R
AD  - Department of Pathology, Beth Israel Deaconess Medical Center, Boston, 
      Massachusetts, USA.
FAU - Idrees, Kamran
AU  - Idrees K
AD  - Department of Surgery, Divsion of Surgical Oncology and Endocrine Surgery, 
      Vanderbilt University Medical Center, Nashville, Tennessee, USA.
FAU - Bailey, Christina Edwards
AU  - Bailey CE
AD  - Department of Surgery, Divsion of Surgical Oncology and Endocrine Surgery, 
      Vanderbilt University Medical Center, Nashville, Tennessee, USA.
FAU - Berlin, Jordan
AU  - Berlin J
AD  - Department of Internal Medicine, Division of Hematology and Oncology, Vanderbilt 
      University Medical Center, Nashville, Tennessee, USA.
LA  - eng
GR  - K12 CA090625/CA/NCI NIH HHS/United States
GR  - P30 DK058404/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20190705
PL  - United States
TA  - J Med Surg Pathol
JT  - Journal of medical & surgical pathology
JID - 101689989
PMC - PMC7175957
MID - NIHMS1025300
OTO - NOTNLM
OT  - Mesenteric tumor deposits
OT  - Peritoneal carcinomatosis
OT  - Small intestinal neuroendocrine tumors
EDAT- 2019/01/01 00:00
MHDA- 2019/01/01 00:01
PMCR- 2020/04/22
CRDT- 2020/04/24 06:00
PHST- 2020/04/24 06:00 [entrez]
PHST- 2019/01/01 00:00 [pubmed]
PHST- 2019/01/01 00:01 [medline]
PHST- 2020/04/22 00:00 [pmc-release]
PST - ppublish
SO  - J Med Surg Pathol. 2019;4(1):1-10. Epub 2019 Jul 5.