PMID- 32322867
OWN - NLM
STAT- MEDLINE
DCOM- 20210112
LR  - 20210112
IS  - 1477-9234 (Electronic)
IS  - 1477-9226 (Linking)
VI  - 49
IP  - 18
DP  - 2020 May 14
TI  - The fabrication of a thiol-modified chitosan magnetic graphene oxide 
      nanocomposite and its adsorption performance towards the illegal drug clenbuterol 
      in pork samples.
PG  - 6097-6107
LID - 10.1039/d0dt00705f [doi]
AB  - A novel thiol (provided by (3-mercaptopropyl) trimethoxysilane, MPTS)-modified 
      chitosan magnetic graphene oxide nanocomposite (Fe(3)O(4)@SiO(2)/GO/CS/MPTS) was 
      synthesized and characterized for the first time as an efficient magnetic sorbent 
      for the enrichment and extraction of trace levels of clenbuterol in pork samples 
      (muscle, fat, heart and liver). Various greatly influential parameters were 
      optimized using a Box-Behnken design (BBD) through the response surface 
      methodology (RSM) to obtain more satisfactory recovery. Under optimum conditions, 
      the method detection limits (MDLs) were in the range of 0.054-0.136 ng g(-1). The 
      recoveries of three spiked levels ranged from 84.7% to 101.1%, and the relative 
      standard deviations (RSDs) were lower than 9.3%. The results of the adsorption 
      experiments showed that the maximum adsorption capacity of 
      Fe(3)O(4)@SiO(2)/GO/CS/MPTS for clenbuterol was 214.13 mg g(-1). The adsorption 
      process was most consistent with pseudo second-order kinetics and Langmuir 
      adsorption isotherm, indicating a homogeneous process with a chemisorptive 
      nature. Also, the nanocomposite exhibited high adsorption capability for 
      clenbuterol compared with Fe(3)O(4)@SiO(2)/GO and Fe(3)O(4)@SiO(2)/GO/CS. In 
      addition, regeneration of the nanocomposite was effectively achieved, and it 
      retained about 82% of its initial capacity after four cycles. All these results 
      indicate that the synthetic nanocomposite is a promising efficient adsorbent for 
      the adsorption of clenbuterol with high adsorption capacity and low cost.
FAU - Jiang, Xu
AU  - Jiang X
AD  - School of Pharmacy, Shenyang Key Laboratory of Functional Drug Carrier Materials, 
      Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, P. R. 
      China. longshanzhao@163.com.
FAU - Pan, Wenyue
AU  - Pan W
FAU - Chen, Mengying
AU  - Chen M
FAU - Yuan, Yunxia
AU  - Yuan Y
FAU - Zhao, Longshan
AU  - Zhao L
LA  - eng
PT  - Journal Article
DEP - 20200423
PL  - England
TA  - Dalton Trans
JT  - Dalton transactions (Cambridge, England : 2003)
JID - 101176026
RN  - 0 (Illicit Drugs)
RN  - 0 (Sulfhydryl Compounds)
RN  - 0 (graphene oxide)
RN  - 7782-42-5 (Graphite)
RN  - 9012-76-4 (Chitosan)
RN  - XTZ6AXU7KN (Clenbuterol)
SB  - IM
MH  - Adsorption
MH  - Animals
MH  - Chitosan/*chemistry
MH  - Clenbuterol/*analysis
MH  - Graphite/*chemistry
MH  - Illicit Drugs/*analysis
MH  - Magnetic Fields
MH  - Nanocomposites/*chemistry
MH  - Particle Size
MH  - Pork Meat/*analysis
MH  - Sulfhydryl Compounds/*chemistry
MH  - Surface Properties
MH  - Swine
EDAT- 2020/04/24 06:00
MHDA- 2021/01/13 06:00
CRDT- 2020/04/24 06:00
PHST- 2020/04/24 06:00 [pubmed]
PHST- 2021/01/13 06:00 [medline]
PHST- 2020/04/24 06:00 [entrez]
AID - 10.1039/d0dt00705f [doi]
PST - ppublish
SO  - Dalton Trans. 2020 May 14;49(18):6097-6107. doi: 10.1039/d0dt00705f. Epub 2020 
      Apr 23.