PMID- 32323040
OWN - NLM
STAT- MEDLINE
DCOM- 20201120
LR  - 20201120
IS  - 1573-2622 (Electronic)
IS  - 0012-4486 (Linking)
VI  - 141
IP  - 3
DP  - 2020 Dec
TI  - High myopic patients with and without foveoschisis: morphological and functional 
      characteristics.
PG  - 227-236
LID - 10.1007/s10633-020-09767-y [doi]
AB  - PURPOSE: Myopic foveoschisis (MF) is characterized by the splitting of the 
      retinal layers in the fovea of patients with high myopia (HM). MF may progress 
      into foveal detachment or macular hole formation with consequent loss of central 
      vision. The aim of this study is to investigate morphological and functional 
      changes of the macular region in myopic subjects with and without foveoschisis. 
      DESIGN: Observational, cross-sectional, comparative study. METHODS: Forty-eight 
      patients with HM and 24 healthy controls were evaluated by spectral 
      domain-optical coherence tomography (SD-OCT), multifocal electroretinography 
      (mfERG) and microperimetry (MP-1) tests to assess macular thickness, 
      functionality and sensitivity values, respectively. The results of the diagnostic 
      examinations were compared between three groups: HM patients with MF (N = 24), HM 
      patients without MF (N = 24) and control group (CG) (N = 24). All statistical 
      analyses were performed with STATA 14.0 (Collage Station, Texas, USA). One-way 
      analysis of variance (ANOVA) followed by Tukey's post hoc test was used to 
      analyze differences between groups unless specified; p values < 0.05 were 
      considered as statistically significant. Gender distribution was compared by the 
      Chi square test. RESULTS: The statistical analysis with one-way ANOVA followed by 
      Tukey's post hoc test showed a significant increase in macular thickness in HM 
      patients with MF when compared to both HM patients without MF and CG. 
      Morphological changes were associated with functional impairment as demonstrated 
      by the significant decrease in amplitude of the P1 wave and MP-1 sensitivity 
      (p < 0.05), according to the anatomical landmarks. CONCLUSIONS: This study showed 
      that the morphological changes observed in the central retina of HM patients with 
      MF are associated with functional alterations. High-tech diagnostic tests such as 
      SD-OCT, mfERG and MP-1 could be useful for management in complications of MF.
FAU - Nebbioso, Marcella
AU  - Nebbioso M
AD  - Department of Sense Organs, Sapienza University of Rome, p. le A. Moro 5, 00185, 
      Rome, Italy.
FAU - Lambiase, Alessandro
AU  - Lambiase A
AUID- ORCID: 0000-0002-8974-991X
AD  - Department of Sense Organs, Sapienza University of Rome, p. le A. Moro 5, 00185, 
      Rome, Italy. alessandro.lambiase@uniroma1.it.
FAU - Gharbiya, Magda
AU  - Gharbiya M
AD  - Department of Sense Organs, Sapienza University of Rome, p. le A. Moro 5, 00185, 
      Rome, Italy.
FAU - Bruscolini, Alice
AU  - Bruscolini A
AD  - Department of Sense Organs, Sapienza University of Rome, p. le A. Moro 5, 00185, 
      Rome, Italy.
FAU - Alisi, Ludovico
AU  - Alisi L
AD  - Department of Sense Organs, Sapienza University of Rome, p. le A. Moro 5, 00185, 
      Rome, Italy.
FAU - Bonfiglio, Vincenza
AU  - Bonfiglio V
AD  - Department of Ophthalmology, University of Catania, Via S. Sofia 76, 95100, 
      Catania, Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20200422
PL  - Netherlands
TA  - Doc Ophthalmol
JT  - Documenta ophthalmologica. Advances in ophthalmology
JID - 0370667
SB  - IM
MH  - Cross-Sectional Studies
MH  - Electroretinography
MH  - Female
MH  - Fovea Centralis/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myopia, Degenerative/diagnostic imaging/*physiopathology
MH  - Retina/physiopathology
MH  - Retinal Perforations/physiopathology
MH  - Retinoschisis/diagnostic imaging/*physiopathology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Visual Field Tests
MH  - Visual Fields/physiology
MH  - Vitrectomy/methods
OTO - NOTNLM
OT  - High myopia
OT  - Microperimetry (MP-1)
OT  - Multifocal electroretinography (mfERG)
OT  - Myopic foveoschisis
OT  - Pathological myopia
OT  - Retinoschisis
OT  - Spectral domain-optical coherence tomography (SD-OCT)
EDAT- 2020/04/24 06:00
MHDA- 2020/11/21 06:00
CRDT- 2020/04/24 06:00
PHST- 2019/09/06 00:00 [received]
PHST- 2020/04/10 00:00 [accepted]
PHST- 2020/04/24 06:00 [pubmed]
PHST- 2020/11/21 06:00 [medline]
PHST- 2020/04/24 06:00 [entrez]
AID - 10.1007/s10633-020-09767-y [pii]
AID - 10.1007/s10633-020-09767-y [doi]
PST - ppublish
SO  - Doc Ophthalmol. 2020 Dec;141(3):227-236. doi: 10.1007/s10633-020-09767-y. Epub 
      2020 Apr 22.