PMID- 32324258
OWN - NLM
STAT- MEDLINE
DCOM- 20210308
LR  - 20210308
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 235
IP  - 11
DP  - 2020 Nov
TI  - Prognostic role and therapeutic susceptibility of cathepsin in various types of 
      solid tumor and leukemia: A systematic review.
PG  - 7709-7730
LID - 10.1002/jcp.29710 [doi]
AB  - Cathepsins (CTSs) are multifunctional proteins that can play prominent roles in 
      cancer progression and metastasis. In this systematic review, we compared the 
      prognosis of CTS subtypes overexpression in leukemia and solid tumors, and 
      investigated the effect of different factors on CTS prognosis. We systematically 
      searched published articles indexed in PubMed, Scopus, Cochrane library, ISI Web 
      of Science, and EmBase databases from February 2000 until January 2020. Among the 
      selected leukemia and solid tumors studies, overexpression of CTS subtypes in 
      newly diagnosed and treated patients were with poor prognosis in 43 studies 
      (79.6%) and with good prognosis in 9 studies (16.6%). However, there were 2 
      studies (3.8%) with either good or poor prognosis, depending on conditions and 
      caner stage and host cell. The relation between CTS and human leukocyte antigen 
      (HLA) in leukemia and solid tumors was mentioned in 7 studies (13%). 
      Overexpression of CTS subtypes in all new case patients had contributed to the 
      induction of poor prognosis. It seems that CTS subtypes, based on the type of 
      cancer and its stage, the type of host cells, and the probable relation with HLA, 
      breed good or poor prognosis in patients with cancer. Therefore, monitoring the 
      overexpression of CTS subtypes and determining the effect of each of these 
      factors on CTS prognosis could be helpful in predicting cancer prognosis both in 
      newly diagnosed or under treatment patients. They could also be useful in finding 
      ways for improving the efficiency of contemporary therapeutic strategies in 
      various types of leukemia and solid tumors.
CI  - (c) 2020 Wiley Periodicals, Inc.
FAU - Hadad, Elham Homaei
AU  - Hadad EH
AD  - Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, 
      Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AD  - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, 
      Ahvaz, Iran.
FAU - Ahmadzadeh, Ahmad
AU  - Ahmadzadeh A
AD  - Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, 
      Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
FAU - Abooali, Alireza
AU  - Abooali A
AD  - Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, 
      Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
FAU - Saki Malehi, Amal
AU  - Saki Malehi A
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz 
      Jundishapur University of Medical Sciences, Ahvaz, Iran.
FAU - Shokouhian, Mohammad
AU  - Shokouhian M
AD  - Department of Hematology and Blood Banking, School of Allied Medical Sciences, 
      Iran University of Medical Sciences, Tehran, Iran.
FAU - Saki, Najmaldin
AU  - Saki N
AUID- ORCID: 0000-0001-8494-5594
AD  - Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, 
      Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20200423
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (Biomarkers, Tumor)
RN  - EC 3.4.- (Cathepsins)
SB  - IM
MH  - Biomarkers, Tumor/*metabolism
MH  - Cathepsins/*metabolism
MH  - Humans
MH  - Leukemia/*metabolism/pathology
MH  - Neoplasms/*metabolism/pathology
MH  - Prognosis
OTO - NOTNLM
OT  - cathepsins
OT  - human leukocyte antigen
OT  - leukemia
OT  - neoplasm
EDAT- 2020/04/24 06:00
MHDA- 2021/03/09 06:00
CRDT- 2020/04/24 06:00
PHST- 2020/01/06 00:00 [received]
PHST- 2020/03/31 00:00 [accepted]
PHST- 2020/04/24 06:00 [pubmed]
PHST- 2021/03/09 06:00 [medline]
PHST- 2020/04/24 06:00 [entrez]
AID - 10.1002/jcp.29710 [doi]
PST - ppublish
SO  - J Cell Physiol. 2020 Nov;235(11):7709-7730. doi: 10.1002/jcp.29710. Epub 2020 Apr 
      23.