PMID- 32325168
OWN - NLM
STAT- MEDLINE
DCOM- 20210825
LR  - 20231111
IS  - 1096-0937 (Electronic)
IS  - 1087-1845 (Print)
IS  - 1087-1845 (Linking)
VI  - 140
DP  - 2020 Jul
TI  - Genomic diversity of the human pathogen Paracoccidioides across the South 
      American continent.
PG  - 103395
LID - S1087-1845(20)30086-4 [pii]
LID - 10.1016/j.fgb.2020.103395 [doi]
AB  - Paracoccidioidomycosis (PCM) is a life-threatening systemic mycosis widely 
      reported in the Gran Chaco ecosystem. The disease is caused by different species 
      from the genus Paracoccidioides, which are all endemic to South and Central 
      America. Here, we sequenced and analyzed 31 isolates of Paracoccidioides across 
      South America, with particular focus on isolates from Argentina and Paraguay. The 
      de novo sequenced isolates were compared with publicly available genomes. 
      Phylogenetics and population genomics revealed that PCM in Argentina and Paraguay 
      is caused by three distinct Paracoccidioides genotypes, P. brasiliensis (S1a and 
      S1b) and P. restrepiensis (PS3). P. brasiliensis S1a isolates from Argentina are 
      frequently associated with chronic forms of the disease. Our results suggest the 
      existence of extensive molecular polymorphism among Paracoccidioides species, and 
      provide a framework to begin to dissect the connection between genotypic 
      differences in the pathogen and the clinical outcomes of the disease.
CI  - Copyright (c) 2020. Published by Elsevier Inc.
FAU - Teixeira, Marcus de Melo
AU  - Teixeira MM
AD  - Northern Arizona University, Flagstaff, AZ, USA; Universidade de Brasilia, 
      Brasilia, Brazil. Electronic address: marcus.teixeira@gmail.com.
FAU - Cattana, Maria Emilia
AU  - Cattana ME
AD  - Northern Arizona University, Flagstaff, AZ, USA; Hospital Dr. Julio C. Perrando, 
      Resistencia, Chaco, Argentina.
FAU - Matute, Daniel R
AU  - Matute DR
AD  - Biology Department, University of North Carolina, Chapel Hill, NC, USA.
FAU - Munoz, Jose F
AU  - Munoz JF
AD  - Broad Institute of MIT and Harvard, Cambridge, USA.
FAU - Arechavala, Alicia
AU  - Arechavala A
AD  - Hospital Muniz, Buenos Aires, Argentina.
FAU - Isbell, Kristin
AU  - Isbell K
AD  - Biology Department, University of North Carolina, Chapel Hill, NC, USA.
FAU - Schipper, Rafael
AU  - Schipper R
AD  - Universidade de Brasilia, Brasilia, Brazil.
FAU - Santiso, Gabriela
AU  - Santiso G
AD  - Hospital Muniz, Buenos Aires, Argentina.
FAU - Tracogna, Fernanda
AU  - Tracogna F
AD  - Hospital Dr. Julio C. Perrando, Resistencia, Chaco, Argentina.
FAU - Sosa, Maria de Los Angeles
AU  - Sosa MLA
AD  - Laboratorio Central De Redes y Programas, Corrientes, Argentina.
FAU - Cech, Norma
AU  - Cech N
AD  - Hospital 4 de Junio, Chaco, Argentina.
FAU - Alvarado, Primavera
AU  - Alvarado P
AD  - Servicio Autonomo Instituto de Biomedicina Dr. Jacinto Convit, Caracas, 
      Venezuela.
FAU - Barreto, Laura
AU  - Barreto L
AD  - Instituto Superior de Formacion Docente Salome Urena, Santo Domingo, Dominican 
      Republic.
FAU - Chacon, Yone
AU  - Chacon Y
AD  - Hospital Senor del Milagro, Salta, Argentina.
FAU - Ortellado, Juana
AU  - Ortellado J
AD  - Universidad Nacional de Asuncion, Asuncion, Paraguay.
FAU - Lima, Cleoni Mendes de
AU  - Lima CM
AD  - Universidade Federal de Rondonia, Porto Velho, Rondonia, Brazil.
FAU - Chang, Marilene Rodrigues
AU  - Chang MR
AD  - Universidade Federal do Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, 
      Brazil.
FAU - Nino-Vega, Gustavo
AU  - Nino-Vega G
AD  - Universidad de Guanajuato, Guanajuato, Mexico.
FAU - Yasuda, Maria Aparecida Shikanai
AU  - Yasuda MAS
AD  - Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Felipe, Maria Sueli Soares
AU  - Felipe MSS
AD  - Universidade Catolica de Brasilia, Brasilia, Distrito Federal, Brazil.
FAU - Negroni, Ricardo
AU  - Negroni R
AD  - Hospital Muniz, Buenos Aires, Argentina.
FAU - Cuomo, Christina A
AU  - Cuomo CA
AD  - Broad Institute of MIT and Harvard, Cambridge, USA.
FAU - Barker, Bridget
AU  - Barker B
AD  - Northern Arizona University, Flagstaff, AZ, USA.
FAU - Giusiano, Gustavo
AU  - Giusiano G
AD  - Universidad Nacional del Nordeste, Resistencia, Chaco, Argentina. Electronic 
      address: gustavogiusiano@yahoo.com.ar.
LA  - eng
GR  - R01 AI153523/AI/NIAID NIH HHS/United States
GR  - R01 GM121750/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200420
PL  - United States
TA  - Fungal Genet Biol
JT  - Fungal genetics and biology : FG & B
JID - 9607601
SB  - IM
MH  - Argentina/epidemiology
MH  - Ecosystem
MH  - Genetic Variation/*genetics
MH  - Genetics, Population
MH  - Genome, Fungal/genetics
MH  - *Genomics
MH  - Genotype
MH  - Humans
MH  - Paracoccidioides/classification/*genetics/pathogenicity
MH  - Paracoccidioidomycosis/classification/epidemiology/*genetics/microbiology
MH  - Paraguay/epidemiology
MH  - Phylogeny
PMC - PMC7385733
MID - NIHMS1604993
OTO - NOTNLM
OT  - Gran Chaco
OT  - Paracoccidioides
OT  - Phylogenomics
OT  - Population genetics
COIS- Declaration of Competing Interest The authors declare no conflicts of interest.
EDAT- 2020/04/24 06:00
MHDA- 2021/08/26 06:00
PMCR- 2021/07/01
CRDT- 2020/04/24 06:00
PHST- 2019/12/15 00:00 [received]
PHST- 2020/02/27 00:00 [revised]
PHST- 2020/04/16 00:00 [accepted]
PHST- 2020/04/24 06:00 [pubmed]
PHST- 2021/08/26 06:00 [medline]
PHST- 2020/04/24 06:00 [entrez]
PHST- 2021/07/01 00:00 [pmc-release]
AID - S1087-1845(20)30086-4 [pii]
AID - 10.1016/j.fgb.2020.103395 [doi]
PST - ppublish
SO  - Fungal Genet Biol. 2020 Jul;140:103395. doi: 10.1016/j.fgb.2020.103395. Epub 2020 
      Apr 20.