PMID- 32326275
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2306-7381 (Electronic)
IS  - 2306-7381 (Linking)
VI  - 7
IP  - 2
DP  - 2020 Apr 21
TI  - Atypical Multibacterial Granulomatous Myositis in a Horse: First Report in Italy.
LID - 10.3390/vetsci7020047 [doi]
LID - 47
AB  - Infectious causes of myositis are reported relatively uncommonly in horses. Among 
      them, bacterial causes include Streptococcus equi subsp. zooepidemicus, 
      Actinobacillus equuli, Fusobacterium spp. Staphylococcus spp, and Corynebacterium 
      pseudotuberculosis. Infection can be spread to muscles via haematogenous or 
      extension from skin lesions. Parasitic myositis has also been documented. In this 
      report, a 12 year-old Italian Quarter Horse mare presented with diffuse 
      subcutaneous nodules and masses ranging from 2 x 3 to 5 x 20 cm in size, and 
      adherent to subcutis and muscles that were first macroscopically and 
      cytologically diagnosed as pyogranulomas. Subsequently, histological, molecular, 
      bacteriological, and biochemical investigations were performed. All the data 
      obtained allowed to diagnose a severe and diffuse multibacterial granulomatous 
      myositis caused by Corynebacterium pseudotuberculosis and Corynebacterium 
      amycolatum. Following the therapy and an initial disappearance of most of the 
      lesions together with a general improvement of the mare, the clinical condition 
      deteriorated, and new nodules appeared. Matrix-assisted laser 
      desorption/ionization time-of-flight (MALDI-TOF) and PCR techniques revealed the 
      presence of bacteria as Glutamicibacter creatinolyticus and Dietzia spp. To the 
      authors' knowledge, this case report represents the first description of 
      multibacterial granulomatous myositis due to Corynebacterium pseudotuberculosis, 
      Corynebacterium amycolatum, Glutamicibacter creatinolyticus, and Dietzia spp. in 
      a horse reared in Italy.
FAU - Rifici, Claudia
AU  - Rifici C
AD  - Department of Veterinary Science, University of Messina, Polo Universitario 
      dell'Annunziata, 98168 Messina (ME), Italy.
FAU - Attili, Anna-Rita
AU  - Attili AR
AUID- ORCID: 0000-0002-9085-7125
AD  - School of Biosciences and Veterinary Medicine, University of Camerino, Via 
      Circonvallazione 93/95, 62024 Matelica (MC), Italy.
FAU - De Biase, Davide
AU  - De Biase D
AD  - Department of Pathology and Animal Health, University of Naples "Federico II", 
      Via Federico Delpino 1, 80137 Napoli, Italy.
FAU - Goncalves Dos Santos, Roselane
AU  - Goncalves Dos Santos R
AD  - Institute of Biological Sciences, Federal University of Minas Gerais, Belo 
      Horizonte, Minas Gerais 31270-901, Brazil.
FAU - Seyffert, Nubia
AU  - Seyffert N
AD  - Institute of Biology, Federal University of Bahia, Salvador-Bahia 40170-115, 
      Brazil.
FAU - De Paula Castro, Thiago Luiz
AU  - De Paula Castro TL
AUID- ORCID: 0000-0002-2869-5065
AD  - Institute of Health Sciences, Federal University of Bahia, Salvador-Bahia 
      40170-115, Brazil.
FAU - Pereira Figueiredo, Henrique Cesar
AU  - Pereira Figueiredo HC
AD  - School of Veterinary, Federal University of Minas Gerais, Belo Horizonte, Minas 
      Gerais 31270-901, Brazil.
FAU - Scaramozzino, Carmelo
AU  - Scaramozzino C
AD  - Scaravet Equine Breeding Center, Via Don Minzoni, 29, 89124 Reggio Calabria, 
      Italy.
FAU - Reale, Stefano
AU  - Reale S
AD  - Molecular Biology Department, Experimental Zooprophylactic Institute (IZS) of 
      Sicily, Via Gino Marinuzzi 3, 90129 Palermo (PA), Italy.
FAU - Paciello, Orlando
AU  - Paciello O
AUID- ORCID: 0000-0003-3091-0905
AD  - Department of Pathology and Animal Health, University of Naples "Federico II", 
      Via Federico Delpino 1, 80137 Napoli, Italy.
FAU - Cuteri, Vincenzo
AU  - Cuteri V
AUID- ORCID: 0000-0001-9536-3506
AD  - School of Biosciences and Veterinary Medicine, University of Camerino, Via 
      Circonvallazione 93/95, 62024 Matelica (MC), Italy.
FAU - Spier, Sharon Jane
AU  - Spier SJ
AD  - Department of Veterinary Medicine and Epidemiology, University of California, 
      Davis, CA 95616, USA.
FAU - Azevedo, Vasco
AU  - Azevedo V
AUID- ORCID: 0000-0002-4775-2280
AD  - Institute of Biological Sciences, Federal University of Minas Gerais, Belo 
      Horizonte, Minas Gerais 31270-901, Brazil.
FAU - Mazzullo, Giuseppe
AU  - Mazzullo G
AD  - Department of Veterinary Science, University of Messina, Polo Universitario 
      dell'Annunziata, 98168 Messina (ME), Italy.
LA  - eng
PT  - Case Reports
DEP - 20200421
PL  - Switzerland
TA  - Vet Sci
JT  - Veterinary sciences
JID - 101680127
PMC - PMC7355418
OTO - NOTNLM
OT  - Corynebacterium pseudotuberculosis
OT  - Dietzia spp.
OT  - Glutamicibacter creatinolyticus
OT  - bacterial myositis
OT  - horses
COIS- The authors declare no conflict of interest.
EDAT- 2020/04/25 06:00
MHDA- 2020/04/25 06:01
PMCR- 2020/04/21
CRDT- 2020/04/25 06:00
PHST- 2020/03/21 00:00 [received]
PHST- 2020/04/07 00:00 [revised]
PHST- 2020/04/17 00:00 [accepted]
PHST- 2020/04/25 06:00 [entrez]
PHST- 2020/04/25 06:00 [pubmed]
PHST- 2020/04/25 06:01 [medline]
PHST- 2020/04/21 00:00 [pmc-release]
AID - vetsci7020047 [pii]
AID - vetsci-07-00047 [pii]
AID - 10.3390/vetsci7020047 [doi]
PST - epublish
SO  - Vet Sci. 2020 Apr 21;7(2):47. doi: 10.3390/vetsci7020047.