PMID- 32326945
OWN - NLM
STAT- MEDLINE
DCOM- 20200908
LR  - 20210110
IS  - 1477-7525 (Electronic)
IS  - 1477-7525 (Linking)
VI  - 18
IP  - 1
DP  - 2020 Apr 23
TI  - Health related quality of life in chronic kidney disease; a descriptive study in 
      a rural Sri Lankan community affected by chronic kidney disease.
PG  - 106
LID - 10.1186/s12955-020-01369-1 [doi]
LID - 106
AB  - INTRODUCTION: The current epidemic of chronic kidney disease (CKD) in Sri Lanka 
      is ascribed to the exponential increase in the number of CKD patients, which 
      cannot be attributed to any known etiology (CKDu). The aim of this study is to 
      describe the health related quality of life (HRQOL) and the associated factors 
      among CKD/CKDu patients in a rural district in Sri Lanka. METHODS: A community 
      based cross-sectional study included 1174 CKD/CKDu patients. Kidney Disease 
      Quality of Life-Short Form was used to assess the HRQOL, while Centre for 
      Epidemiologic Studies Depression Scale, General Health Questionnaire (GHQ) 12 and 
      CKD Symptom Index - Sri Lanka were used to assess presence of depression, 
      psychological distress and symptom burden respectively. Three summary scores; 
      kidney disease (KDSC), physical (PCS) and mental (MCS) are derived from Kidney 
      Disease Quality of Life-Short Form (KDQOL-SF). RESULTS: Mean age of the study 
      population was 58.3 years (standard deviation (SD) 10.7). Median KDSC (58.4; 
      inter-quartile range (IQR) 54.2-63.4), was higher than the median scores of PCS 
      (35.0; IQR 26.2-41.9) and MCS (58.4; IQR 54.2-63.4). Multiple linear regression 
      revealed low income, advanced stages of CKD, symptom burden, being positive for 
      depression and psychological distress were significantly associated with low 
      HRQOL. CONCLUSION: The HRQOL of the CKD patients in this rural Sri Lankan 
      population was found to be poor. Superior socio-economic status, less physical 
      and psychological symptom burden were found to be independently associated with 
      better HRQOL. Periodical screening of the CKD patients for depression and 
      psychological distress and measures to alleviate symptom burden seem to be 
      important to improve the HRQOL of these patients.
FAU - Senanayake, Sameera
AU  - Senanayake S
AUID- ORCID: 0000-0002-5606-2046
AD  - Epidemiology Unit, Ministry of Health, Colombo, Sri Lanka. sam197902@gmail.com.
FAU - Gunawardena, Nalika
AU  - Gunawardena N
AD  - World Health Organization, Colombo, Sri Lanka.
FAU - Palihawadana, Paba
AU  - Palihawadana P
AD  - Epidemiology Unit, Ministry of Health, Colombo, Sri Lanka.
FAU - Senanayake, Shanika
AU  - Senanayake S
AD  - Australian Centre for Health Service Innovation, Queensland University of 
      Technology, Brisbane, Australia.
FAU - Karunarathna, R
AU  - Karunarathna R
AD  - North Central Provincial Directors Office, Anuradhapura, Sri Lanka.
FAU - Kumara, Priyantha
AU  - Kumara P
AD  - North Central Provincial Directors Office, Anuradhapura, Sri Lanka.
FAU - Kularatna, Sanjeewa
AU  - Kularatna S
AUID- ORCID: 0000-0001-5650-154X
AD  - Australian Centre for Health Service Innovation, Queensland University of 
      Technology, Brisbane, Australia.
LA  - eng
GR  - 001/WHO_/World Health Organization/International
PT  - Journal Article
DEP - 20200423
PL  - England
TA  - Health Qual Life Outcomes
JT  - Health and quality of life outcomes
JID - 101153626
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Depression/diagnosis/*epidemiology/psychology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Quality of Life/*psychology
MH  - Renal Insufficiency, Chronic/*epidemiology/psychology
MH  - Rural Population/statistics & numerical data
MH  - Socioeconomic Factors
MH  - Sri Lanka/epidemiology
PMC - PMC7178581
OTO - NOTNLM
OT  - Chronic kidney disease
OT  - Chronic kidney disease of unknown etiology
OT  - Quality of life
OT  - Sri Lanka
COIS- The authors declare that they have no competing interests.
EDAT- 2020/04/25 06:00
MHDA- 2020/09/09 06:00
PMCR- 2020/04/23
CRDT- 2020/04/25 06:00
PHST- 2019/04/18 00:00 [received]
PHST- 2020/04/16 00:00 [accepted]
PHST- 2020/04/25 06:00 [entrez]
PHST- 2020/04/25 06:00 [pubmed]
PHST- 2020/09/09 06:00 [medline]
PHST- 2020/04/23 00:00 [pmc-release]
AID - 10.1186/s12955-020-01369-1 [pii]
AID - 1369 [pii]
AID - 10.1186/s12955-020-01369-1 [doi]
PST - epublish
SO  - Health Qual Life Outcomes. 2020 Apr 23;18(1):106. doi: 
      10.1186/s12955-020-01369-1.