PMID- 32327716
OWN - NLM
STAT- MEDLINE
DCOM- 20201130
LR  - 20231113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Apr 23
TI  - Admixture and natural selection shaped genomes of an Austronesian-speaking 
      population in the Solomon Islands.
PG  - 6872
LID - 10.1038/s41598-020-62866-3 [doi]
LID - 6872
AB  - People in the Solomon Islands today are considered to have derived from Asian- 
      and Papuan-related ancestors. Papuan-related ancestors colonized Near Oceania 
      about 47,000 years ago, and Asian-related ancestors were Austronesian 
      (AN)-speaking population, called Lapita, who migrated from Southeast Asia about 
      3,500 years ago. These two ancestral populations admixed in Near Oceania before 
      the expansion of Lapita people into Remote Oceania. To understand the impact of 
      the admixture on the adaptation of AN-speaking Melanesians in Near Oceania, we 
      performed the genome-wide single nucleotide polymorphism (SNP) analysis of 21 
      individuals from Munda, the main town of the New Georgia Islands in the western 
      Solomon Islands. Population samples from Munda were genetically similar to other 
      Solomon Island population samples. The analysis of genetic contribution from the 
      two different ancestries to the Munda genome revealed significantly higher 
      proportions of Asian- and Papuan-related ancestries in the region containing the 
      annexin A1 (ANXA1) gene (Asian component > 82.6%) and in the human leukocyte 
      antigen (HLA) class II region (Papuan component > 85.4%), respectively. These 
      regions were suspected to have undergone natural selection since the time of 
      admixture. Our results suggest that admixture had affected adaptation of 
      AN-speaking Melanesians in the Solomon Islands.
FAU - Isshiki, Mariko
AU  - Isshiki M
AD  - Department of Biological Sciences, Graduate School of Science, The University of 
      Tokyo, Tokyo, 113-0033, Japan.
FAU - Naka, Izumi
AU  - Naka I
AD  - Department of Biological Sciences, Graduate School of Science, The University of 
      Tokyo, Tokyo, 113-0033, Japan.
FAU - Watanabe, Yusuke
AU  - Watanabe Y
AD  - Department of Biological Sciences, Graduate School of Science, The University of 
      Tokyo, Tokyo, 113-0033, Japan.
FAU - Nishida, Nao
AU  - Nishida N
AD  - Genome Medical Science Project, Research Center for Hepatitis and Immunology, 
      National Center for Global Health and Medicine, Chiba, 272-8516, Japan.
FAU - Kimura, Ryosuke
AU  - Kimura R
AUID- ORCID: 0000-0003-0100-273X
AD  - Department of Human Biology and Anatomy, Graduate School of Medicine, University 
      of the Ryukyus, Nishihara, 903-0125, Japan.
FAU - Furusawa, Takuro
AU  - Furusawa T
AD  - Graduate School of Asian and African Area Studies, Kyoto University, Kyoto, 
      606-8501, Japan.
FAU - Natsuhara, Kazumi
AU  - Natsuhara K
AD  - Department of International Health and Nursing, Faculty of Nursing, Toho 
      University, Tokyo, 143-8540, Japan.
FAU - Yamauchi, Taro
AU  - Yamauchi T
AD  - Faculty of Health Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
FAU - Nakazawa, Minato
AU  - Nakazawa M
AUID- ORCID: 0000-0003-2345-8455
AD  - Graduate School of Health Sciences, Kobe University, Kobe, 654-0142, Japan.
FAU - Ishida, Takafumi
AU  - Ishida T
AD  - Department of Biological Sciences, Graduate School of Science, The University of 
      Tokyo, Tokyo, 113-0033, Japan.
FAU - Eddie, Ricky
AU  - Eddie R
AD  - National Gizo Hospital, Ministry of Health and Medical Services, P.O. Box 36, 
      Gizo, Solomon Islands.
FAU - Ohtsuka, Ryutaro
AU  - Ohtsuka R
AD  - Japan Wildlife Research Center, Tokyo, 130-8606, Japan.
FAU - Ohashi, Jun
AU  - Ohashi J
AD  - Department of Biological Sciences, Graduate School of Science, The University of 
      Tokyo, Tokyo, 113-0033, Japan. juno-tky@umin.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200423
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Chromosomes, Human, Pair 6/genetics
MH  - Computer Simulation
MH  - *Gene Pool
MH  - *Genome, Human
MH  - Humans
MH  - Immunity
MH  - Melanesia
MH  - Native Hawaiian or Other Pacific Islander/*genetics
MH  - Papua New Guinea
MH  - Phylogeny
MH  - Principal Component Analysis
MH  - *Selection, Genetic
PMC - PMC7181741
COIS- The authors declare no competing interests.
EDAT- 2020/04/25 06:00
MHDA- 2020/12/01 06:00
PMCR- 2020/04/23
CRDT- 2020/04/25 06:00
PHST- 2019/01/31 00:00 [received]
PHST- 2020/03/16 00:00 [accepted]
PHST- 2020/04/25 06:00 [entrez]
PHST- 2020/04/25 06:00 [pubmed]
PHST- 2020/12/01 06:00 [medline]
PHST- 2020/04/23 00:00 [pmc-release]
AID - 10.1038/s41598-020-62866-3 [pii]
AID - 62866 [pii]
AID - 10.1038/s41598-020-62866-3 [doi]
PST - epublish
SO  - Sci Rep. 2020 Apr 23;10(1):6872. doi: 10.1038/s41598-020-62866-3.