PMID- 32328824
OWN - NLM
STAT- MEDLINE
DCOM- 20210702
LR  - 20210731
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 35
IP  - 4
DP  - 2021 Apr
TI  - Comprehensive Analysis of Adverse Events Associated with Gastric Peroral 
      Endoscopic Myotomy: An International Multicenter Study.
PG  - 1755-1764
LID - 10.1007/s00464-020-07570-z [doi]
AB  - BACKGROUND: Gastric peroral endoscopic myotomy (G-POEM) has emerged as an 
      effective management approach for patients with refractory gastroparesis. This 
      study aims to comprehensively study the safety of G-POEM and describe the 
      predictive factors of adverse events (AEs) occurrence. METHODS: This study is a 
      retrospective study involving 13 tertiary care centers (7 USA, 1 South America, 4 
      Europe, and 1 Asia). Patients who underwent G-POEM for refractory gastroparesis 
      were included. Cases were identified by the occurrence of AEs. For each case, two 
      controls were randomly selected and matched for age (+/- 10 years), gender, and 
      etiology of gastroparesis. RESULTS: A total of 216 patients underwent G-POEM for 
      gastroparesis. Overall, 31 (14%) AEs were encountered [mild 24 (77%), moderate 5 
      (16%), and severe 2 (6%)] during the duration of the study. The most common AE 
      was abdominal pain (n = 16), followed by mucosotomy (n = 5) and capnoperitoneum 
      (n = 4), and AEs were most commonly identified within the first 48-h 
      post-procedure 18 (58%). The risk of adverse event occurrence was significantly 
      higher for endoscopists with experience of < 20 G-POEM procedures (OR 3.03 
      [1.03-8.94], p < 0.05). CONCLUSION: G-POEM seems to be a safe intervention for 
      refractory gastroparesis. AEs are most commonly mild and managed conservatively. 
      Longitudinal mucosal incision, use of hook knife, use of clips for mucosal 
      closure and endoscopist's experience with > 20 G-POEM procedures is significantly 
      associated with decreased incidence of AEs.
FAU - Ichkhanian, Y
AU  - Ichkhanian Y
AD  - Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, 
      Baltimore, MD, USA.
FAU - Vosoughi, K
AU  - Vosoughi K
AD  - Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, 
      Baltimore, MD, USA.
FAU - Aghaie Meybodi, M
AU  - Aghaie Meybodi M
AD  - Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, 
      Baltimore, MD, USA.
FAU - Jacques, J
AU  - Jacques J
AD  - Gastroenterology Department, Limoges University Hospital, 2 Avenue Martin Luther 
      King, 87042, Rouen, France.
FAU - Sethi, A
AU  - Sethi A
AD  - Division of Digestive and Liver Diseases, Columbia University Medical Center, New 
      York, NY, USA.
FAU - Patel, A A
AU  - Patel AA
AD  - Division of Digestive and Liver Diseases, Columbia University Medical Center, New 
      York, NY, USA.
FAU - Aadam, A A
AU  - Aadam AA
AD  - Division of Gastroenterology and Hepatology, Northwestern University Feinberg 
      School of Medicine, Chicago, IL, USA.
FAU - Triggs, J R
AU  - Triggs JR
AD  - Division of Gastroenterology and Hepatology, Northwestern University Feinberg 
      School of Medicine, Chicago, IL, USA.
FAU - Bapaye, A
AU  - Bapaye A
AD  - Department of Digestive Diseases & Endoscopy, Deenanath Mangeshkar Hospital and 
      Research Center, Pune, Maharashtra, India.
FAU - Dorwat, S
AU  - Dorwat S
AD  - Department of Digestive Diseases & Endoscopy, Deenanath Mangeshkar Hospital and 
      Research Center, Pune, Maharashtra, India.
FAU - Benias, P
AU  - Benias P
AD  - Division of Gastroenterology, Zucker School of Medicine at Hofstra/Northwell, 
      Long Island Jewish Medical Center, Northwell Health System, New Hyde Park, NY, 
      USA.
FAU - Chaves, D M
AU  - Chaves DM
AD  - Gastroenterologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, 
      Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Barret, M
AU  - Barret M
AD  - Gastroenterology Unit, Cochin University Hospital, Universite Paris Descartes, 
      Paris, France.
AD  - Unite INSERM U1016, Universite Paris Descartes, Sorbonne Paris Cite, Paris, 
      France.
FAU - Law, R J
AU  - Law RJ
AD  - University of Michigan Health Care System, Ann Arbor, USA.
FAU - Browers, N
AU  - Browers N
AD  - University of Michigan Health Care System, Ann Arbor, USA.
FAU - Pioche, M
AU  - Pioche M
AD  - Service d'Hepato-gastro-enterologie, Hopital Edouard Herriot, CHU Lyon, Lyon, 
      France.
FAU - Draganov, P V
AU  - Draganov PV
AD  - Division of Gastroenterology, Hepatology and Nutrition, University of Florida, 
      Gainesville, FL, USA.
FAU - Kotzev, A
AU  - Kotzev A
AD  - Clinic of Gastroenterology, University Hospital "Alexandrovska", Sofia, Bulgaria.
FAU - Estremera, F
AU  - Estremera F
AD  - Clinic of Gastroenterology, University Hospital "Alexandrovska", Sofia, Bulgaria.
FAU - Albeniz, E
AU  - Albeniz E
AD  - Division of Gastroenterology, Complejo Hospitalario de Navarra, Pamplona, Spain.
FAU - Ujiki, M B
AU  - Ujiki MB
AD  - Section of Minimally Invasive Surgery, Department of Surgery, NorthShore 
      University Health System, Evanston, IL, USA.
FAU - Callahan, Z M
AU  - Callahan ZM
AD  - Section of Minimally Invasive Surgery, Department of Surgery, NorthShore 
      University Health System, Evanston, IL, USA.
FAU - Itani, M I
AU  - Itani MI
AD  - Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, 
      Baltimore, MD, USA.
FAU - Brewer, O G
AU  - Brewer OG
AD  - Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, 
      Baltimore, MD, USA.
FAU - Khashab, M A
AU  - Khashab MA
AD  - Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, 
      Baltimore, MD, USA. mkhasha1@jhmi.edu.
AD  - Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Sheikh Zayed 
      Bldg, 1800 Orleans Street, Suite 7125G, Baltimore, MD, 21287, USA. 
      mkhasha1@jhmi.edu.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20200423
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
SB  - IM
EIN - Surg Endosc. 2020 May 18;:. PMID: 32424623
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Gastroparesis/surgery
MH  - Humans
MH  - *Internationality
MH  - Male
MH  - Middle Aged
MH  - Physicians
MH  - Pyloromyotomy/*adverse effects
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Adverse events
OT  - G-POEM
OT  - Gastric peroral endoscopic myotomy
OT  - Gastroparesis
EDAT- 2020/04/25 06:00
MHDA- 2021/07/03 06:00
CRDT- 2020/04/25 06:00
PHST- 2019/12/30 00:00 [received]
PHST- 2020/04/15 00:00 [accepted]
PHST- 2020/04/25 06:00 [pubmed]
PHST- 2021/07/03 06:00 [medline]
PHST- 2020/04/25 06:00 [entrez]
AID - 10.1007/s00464-020-07570-z [pii]
AID - 10.1007/s00464-020-07570-z [doi]
PST - ppublish
SO  - Surg Endosc. 2021 Apr;35(4):1755-1764. doi: 10.1007/s00464-020-07570-z. Epub 2020 
      Apr 23.