PMID- 32329149
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20200624
LR  - 20200624
IS  - 1520-636X (Electronic)
IS  - 0899-0042 (Linking)
VI  - 32
IP  - 7
DP  - 2020 Jul
TI  - beta-Cyclodextrin-modified covalent organic framework as chiral stationary phase for 
      the separation of amino acids and beta-blockers by capillary electrochromatography.
PG  - 1008-1019
LID - 10.1002/chir.23227 [doi]
AB  - Covalent organic frameworks (COFs) as a novel stationary phase have attracted 
      much attention in the field of chromatography owing to their permanent nanoscale 
      porosity, higher surface area, and exceptional stabilities. Here, a novel 
      isocyanate-beta-cyclodextrin-modified COF (MDI-beta-CD-modified COF) was synthesized 
      using isocyanate-beta-cyclodextrin as the chiral selector and imine-based TpPa-1 COF 
      as the matrix by a bottom-up strategy. The reaction condition and the structure 
      of MDI-beta-CD-modified COF were optimized and characterized by X-ray diffraction 
      (XRD), Fourier-transform infrared (FT-IR) spectra, nitrogen adsorption/desorption 
      (Brunauer-Emmett-Teller [BET]), and thermogravimetric analysis (TGA). And then 
      the coated open-tubular column (OT column) was prepared using MDI-beta-CD-modified 
      COF as chiral stationary phase (CSP) by in situ growth approach, which exhibited 
      excellent stability and repeatability. For seven consecutive runs, the intraday 
      and interday relative standard deviations (RSDs) were in range from 0.35% to 
      2.21% for the migration time of histidine. The column-to-column reproducibility 
      ranged from 2.39% to 3.08%. Meanwhile, the separation of eight compounds 
      including four amino acids and four beta-blockers by capillary electrochromatography 
      sufficiently verified the favorable chiral resolution properties of the 
      MDI-beta-CD-modified COF-coated OT column. This strategy of fabricating 
      MDI-beta-CD-modified COF-coated OT column expanded the application of imine-based 
      COFs in chromatographic analytical fields.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Li, Yingjie
AU  - Li Y
AD  - College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, 
      Heilongjiang, China.
FAU - Lin, Xiaotong
AU  - Lin X
AUID- ORCID: 0000-0003-0135-5885
AD  - College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, 
      Heilongjiang, China.
FAU - Qin, Shili
AU  - Qin S
AD  - College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, 
      Heilongjiang, China.
FAU - Gao, Lidi
AU  - Gao L
AD  - College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, 
      Heilongjiang, China.
FAU - Tang, Yimin
AU  - Tang Y
AD  - College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, 
      Heilongjiang, China.
FAU - Liu, Shuren
AU  - Liu S
AD  - College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 
      China.
FAU - Wang, Yuanyuan
AU  - Wang Y
AD  - College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, 
      Heilongjiang, China.
LA  - eng
GR  - no. YJSCX2018-ZD12/Qiqihar University Graduate Innovation Project 
      Foundation/International
GR  - No. 135409205/Young Creative Program of the Fundamental Research Funds in 
      Heilongjiang Provincial Universities/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200424
PL  - United States
TA  - Chirality
JT  - Chirality
JID - 8914261
SB  - IM
OTO - NOTNLM
OT  - capillary electrochromatography
OT  - chiral stationary phase
OT  - covalent organic frameworks
OT  - open-tubular column
OT  - beta-cyclodextrin
EDAT- 2020/04/25 06:00
MHDA- 2020/04/25 06:01
CRDT- 2020/04/25 06:00
PHST- 2020/02/01 00:00 [received]
PHST- 2020/03/14 00:00 [revised]
PHST- 2020/03/20 00:00 [accepted]
PHST- 2020/04/25 06:00 [pubmed]
PHST- 2020/04/25 06:01 [medline]
PHST- 2020/04/25 06:00 [entrez]
AID - 10.1002/chir.23227 [doi]
PST - ppublish
SO  - Chirality. 2020 Jul;32(7):1008-1019. doi: 10.1002/chir.23227. Epub 2020 Apr 24.