PMID- 32330537
OWN - NLM
STAT- MEDLINE
DCOM- 20200518
LR  - 20200518
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 747
DP  - 2020 Jul 15
TI  - Associations of IL6 rs1800795, BLK rs13277113, TIMP3 rs9621532, IL1RL1 rs1041973 
      and IL1RAP rs4624606 single gene polymorphisms with laryngeal squamous cell 
      carcinoma.
PG  - 144700
LID - S0378-1119(20)30369-3 [pii]
LID - 10.1016/j.gene.2020.144700 [doi]
AB  - OBJECTIVE: Survival rate of laryngeal squamous cell carcinoma (LSCC) patients is 
      not improving. To understand more complete biology of LSCC, studies focused on 
      identification of new specific and prognostic markers are performed. The aim of 
      current study was to evaluate the impact of five different single nucleotide 
      polymorphisms (SNP) (IL6 rs1800795, BLK rs13277113, TIMP3 rs9621532, IL1RL1 
      rs1041973 and IL1RAP rs4624606) on LSCC development. MATERIAL AND METHODS: A 
      total of 891 subjects (353 histologically verified LSCC patients and 538 healthy 
      controls) were involved in this study. The genotyping was carried out using the 
      real-time-PCR. RESULTS: Statistical analysis revealed statistically significant 
      associations between TIMP3 rs96215332 variants and LSCC in the codominant 
      (OR = 0.600; 95% CI: 0.390-0.922; p = 0.020), overdominant (OR = 0.599; 95% CI: 
      0.390-0.922; p = 0.020) and additive (OR = 0.675; 95% CI: 0.459-0.991; p = 0.045) 
      models. Also, significant variants of IL1RAP rs4624606 were determined in the 
      codominant (OR = 1.372; 95% CI: 1.031-1.827; p = 0.030), overdominant 
      (OR = 1.353; 95% CI: 1.018-1.798; p = 0.037) and additive (OR = 1.337; 95% CI: 
      1.038-1.724; p = 0.025) models. CONCLUSION: Results of the current study indicate 
      significant associations between TIMP3 rs9621532 and IL1RAP rs4624606 gene 
      polymorphisms and LSCC development.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Pasvenskaite, Agne
AU  - Pasvenskaite A
AD  - Department of Otorhinolaryngology, Lithuanian University of Health Sciences, 
      Kaunas, Lithuania. Electronic address: agne.pasvenskaite@lsmuni.lt.
FAU - Vilkeviciute, Alvita
AU  - Vilkeviciute A
AD  - Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, 
      Lithuania, Lithuania.
FAU - Liutkeviciene, Rasa
AU  - Liutkeviciene R
AD  - Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, 
      Lithuania, Lithuania.
FAU - Gedvilaite, Greta
AU  - Gedvilaite G
AD  - Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, 
      Lithuania, Lithuania.
FAU - Liutkevicius, Vykintas
AU  - Liutkevicius V
AD  - Department of Otorhinolaryngology, Lithuanian University of Health Sciences, 
      Kaunas, Lithuania.
FAU - Uloza, Virgilijus
AU  - Uloza V
AD  - Department of Otorhinolaryngology, Lithuanian University of Health Sciences, 
      Kaunas, Lithuania.
LA  - eng
PT  - Journal Article
DEP - 20200421
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (IL1RAP protein, human)
RN  - 0 (IL1RL1 protein, human)
RN  - 0 (Interleukin-1 Receptor Accessory Protein)
RN  - 0 (Interleukin-1 Receptor-Like 1 Protein)
RN  - 0 (Interleukin-6)
RN  - 0 (TIMP3 protein, human)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-3)
RN  - EC 2.7.10.2 (BLK protein, human)
RN  - EC 2.7.10.2 (src-Family Kinases)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-1 Receptor Accessory Protein/*genetics
MH  - Interleukin-1 Receptor-Like 1 Protein/*genetics
MH  - Interleukin-6/*genetics
MH  - Laryngeal Neoplasms/*genetics
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Protein Interaction Maps/genetics
MH  - Tissue Inhibitor of Metalloproteinase-3/*genetics
MH  - src-Family Kinases/*genetics
OTO - NOTNLM
OT  - BLK
OT  - Gene polymorphism
OT  - IL-6
OT  - IL1RAP
OT  - IL1RL1
OT  - Laryngeal squamous cell carcinoma
OT  - TIMP3
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/04/25 06:00
MHDA- 2020/05/19 06:00
CRDT- 2020/04/25 06:00
PHST- 2020/03/01 00:00 [received]
PHST- 2020/04/06 00:00 [revised]
PHST- 2020/04/18 00:00 [accepted]
PHST- 2020/04/25 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2020/04/25 06:00 [entrez]
AID - S0378-1119(20)30369-3 [pii]
AID - 10.1016/j.gene.2020.144700 [doi]
PST - ppublish
SO  - Gene. 2020 Jul 15;747:144700. doi: 10.1016/j.gene.2020.144700. Epub 2020 Apr 21.