PMID- 32330771
OWN - NLM
STAT- MEDLINE
DCOM- 20201120
LR  - 20201120
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 186
DP  - 2020 Jul
TI  - Associations between the incidence and mortality rates of type 2 diabetes 
      mellitus and long-term exposure to ambient air pollution: A 12-year cohort study 
      in northern China.
PG  - 109551
LID - S0013-9351(20)30444-8 [pii]
LID - 10.1016/j.envres.2020.109551 [doi]
AB  - BACKGROUND: Ambient air pollution has recently been related to type 2 diabetes 
      mellitus (T2DM), a disease that has caused an economic and health burden 
      worldwide. Evidence of an association between air pollution and T2DM was reported 
      in the United States and Europe. However, few studies have focused on the 
      association with high levels of air pollutants in a developing country. 
      OBJECTIVES: We conducted a 12-year cohort study to assess the incidence and 
      mortality of T2DM associated with long-term exposure to PM(10), SO(2), and NO(2). 
      METHODS: A retrospective cohort with participants from four cities in northern 
      China was conducted to assess mortality and incidence of T2DM from 1998 to 2009. 
      Incidence of T2DM was self-reported, and incident intake of an antidiabetic drug 
      or injection of insulin simultaneously and mortality of T2DM was obtained from a 
      family member and double checked against death certificates provided from the 
      local center for disease control and prevention. Individual pollution exposures 
      were the mean concentrations of pollutants estimated from the local environmental 
      monitoring centers over the survival years. Hazard ratios (HRs) were estimated 
      using Cox regression models after adjusting for potential confounding factors. 
      RESULTS: A total of 39 054 participants were recruited into the mortality cohort, 
      among which 59 subjects died from T2DM; 38 529 participants were analyzed in the 
      incidence cohort, and 1213 developed new cases of T2DM. For each 10 mug/m(3) 
      increase in PM(10), SO(2), and NO(2), the adjusted HRs and 95% confidence 
      interval (CI) for diabetic incidence were 1.831 (1.778, 1.886), 1.287 (1.256, 
      1.318), and 1.472 (1.419, 1.528), respectively. Similar results can be observed 
      in the analysis of diabetic mortality with HRs (95% CI) up to 2.260 (1.732, 
      2.950), 1.130 (1.042, 1.225), and 1.525 (1.280, 1.816), respectively. 
      CONCLUSIONS: Our results suggested that long-term exposure to high levels of 
      PM(10), SO(2), and NO(2) increase risk of incident and mortality of T2DM in 
      China.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Shan, Anqi
AU  - Shan A
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Zhang, Li-Wen
AU  - Zhang LW
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Chen, Xi
AU  - Chen X
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Li, Xuejun
AU  - Li X
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Wu, Hui
AU  - Wu H
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Yan, Mengfan
AU  - Yan M
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Li, Yaoyan
AU  - Li Y
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Xian, Ping
AU  - Xian P
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Ma, Zhao
AU  - Ma Z
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Li, Chaokang
AU  - Li C
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Guo, Pengyi
AU  - Guo P
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China.
FAU - Dong, Guang-Hui
AU  - Dong GH
AD  - Department of Preventive Medicine, School of Public Health, Sun Yat-sen 
      University, Guangzhou, 510080, China.
FAU - Liu, Ya-Min
AU  - Liu YM
AD  - School of Medicine and Life Sciences, Shandong Academy of Medical Sciences, 
      Jinan, 250062, China.
FAU - Chen, Jie
AU  - Chen J
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, No. 77 Puhe Road, Shenbei New District, 110122, 
      Shenyang, Liaoning, China.
FAU - Wang, Tong
AU  - Wang T
AD  - School of Public Health, Shanxi Medical University, Taiyuan, 030001, China.
FAU - Zhao, Bao-Xin
AU  - Zhao BX
AD  - Taiyuan Center for Disease Control and Prevention, Taiyuan, 030001, China.
FAU - Tang, Nai-Jun
AU  - Tang NJ
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of 
      Environment, Nutrition, and Public Health, Tianjin Medical University, Tianjin, 
      300070, China; Center for International Collaborative Research on Environment, 
      Nutrition and Public Health, Tianjin, 300070, China. Electronic address: 
      tangnaijun@tmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200418
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - *Air Pollutants/adverse effects/analysis
MH  - *Air Pollution/adverse effects/analysis
MH  - China/epidemiology
MH  - Cities
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/chemically induced/epidemiology
MH  - Environmental Exposure/adverse effects/analysis
MH  - Europe
MH  - Humans
MH  - Incidence
MH  - Particulate Matter/analysis/toxicity
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Air pollution
OT  - Incidence
OT  - Mortality
OT  - Retrospective cohort
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/04/25 06:00
MHDA- 2020/11/21 06:00
CRDT- 2020/04/25 06:00
PHST- 2019/08/30 00:00 [received]
PHST- 2020/04/12 00:00 [revised]
PHST- 2020/04/16 00:00 [accepted]
PHST- 2020/04/25 06:00 [pubmed]
PHST- 2020/11/21 06:00 [medline]
PHST- 2020/04/25 06:00 [entrez]
AID - S0013-9351(20)30444-8 [pii]
AID - 10.1016/j.envres.2020.109551 [doi]
PST - ppublish
SO  - Environ Res. 2020 Jul;186:109551. doi: 10.1016/j.envres.2020.109551. Epub 2020 
      Apr 18.