PMID- 32332215 OWN - NLM STAT- MEDLINE DCOM- 20210407 LR - 20240124 IS - 2162-0989 (Electronic) IS - 2162-0989 (Linking) VI - 9 IP - 3 DP - 2020 May-Jun TI - Latest Developments in Polypoidal Choroidal Vasculopathy: Epidemiology, Etiology, Diagnosis, and Treatment. PG - 260-268 LID - 10.1097/01.APO.0000656992.00746.48 [doi] AB - Polypoidal choroidal vasculopathy (PCV) is a condition characterized by multiple, recurrent, serosanguineous pigment epithelial detachments, and neurosensory retinal detachments due to abnormal aneurysmal neovascular lesions. It is generally considered as a variant of neovascular age-related macular degeneration, but there are some differences between the clinical presentation, natural history, and treatment response between patients with PCV and typical neovascular age-related macular degeneration patients. Over the past decade, new research and technological advancements have greatly improved our understanding of the PCV disease process and the management of PCV. This review aims to summarize the recent research findings to highlight the epidemiology, pathogenesis, genetics, the application of various diagnostic tools for PCV, and the available treatment options for PCV. FAU - Chaikitmongkol, Voraporn AU - Chaikitmongkol V AD - Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Cheung, Chui Ming Gemmy AU - Cheung CMG AD - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore. AD - Duke-NUS Medical School, National University of Singapore, Singapore, Republic of Singapore. FAU - Koizumi, Hideki AU - Koizumi H AD - Department of Ophthalmology, University of the Ryukyus, Okinawa, Japan. FAU - Govindahar, Vishal AU - Govindahar V AD - Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. FAU - Chhablani, Jay AU - Chhablani J AD - L V Prasad Eye Institute, Bhubaneshwar, India. FAU - Lai, Timothy Y Y AU - Lai TYY AD - Hong Kong Eye Hospital, Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong. AD - 2010 Retina & Macula Center, Kowloon, Hong Kong. LA - eng PT - Journal Article PT - Review PL - United States TA - Asia Pac J Ophthalmol (Phila) JT - Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) JID - 101583622 SB - IM MH - Choroid/*diagnostic imaging MH - Choroid Diseases/diagnosis/*epidemiology/therapy MH - *Disease Management MH - Fluorescein Angiography/*methods MH - Fundus Oculi MH - Global Health MH - Humans MH - Morbidity MH - Polyps/diagnosis/*epidemiology/therapy MH - Prognosis MH - Tomography, Optical Coherence/*methods PMC - PMC7299215 COIS- The authors declare no conflicts of interest. EDAT- 2020/04/26 06:00 MHDA- 2021/04/10 06:00 PMCR- 2020/06/17 CRDT- 2020/04/26 06:00 PHST- 2020/04/26 06:00 [pubmed] PHST- 2021/04/10 06:00 [medline] PHST- 2020/04/26 06:00 [entrez] PHST- 2020/06/17 00:00 [pmc-release] AID - S2162-0989(23)00207-4 [pii] AID - APJO-2020-41 [pii] AID - 10.1097/01.APO.0000656992.00746.48 [doi] PST - ppublish SO - Asia Pac J Ophthalmol (Phila). 2020 May-Jun;9(3):260-268. doi: 10.1097/01.APO.0000656992.00746.48.