PMID- 32332768
OWN - NLM
STAT- MEDLINE
DCOM- 20201130
LR  - 20210424
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Apr 24
TI  - Late-pregnancy uterine artery ligation increases susceptibility to postnatal 
      Western diet-induced fat accumulation in adult female offspring.
PG  - 6926
LID - 10.1038/s41598-020-63392-y [doi]
LID - 6926
AB  - Stressors during the fetal and postnatal period affect the growth and 
      developmental trajectories of offspring, causing lasting effects on physiologic 
      regulatory systems. Here, we tested whether reduced uterine artery blood flow in 
      late pregnancy would alter body composition in the offspring, and whether feeding 
      offspring a western diet (WD) would aggravate these programming effects. Pregnant 
      rats underwent bilateral uterine artery ligation (BUAL) or sham surgery on 
      gestational day (GD)18 (term = GD22). At weaning, offspring from each group 
      received either a normal diet (ND) or a WD. BUAL surgery increased fetal loss and 
      caused offspring growth restriction, albeit body weights were no longer different 
      at weaning, suggesting postnatal catch-up growth. BUAL did not affect body weight 
      gain, fat accumulation, or plasma lipid profile in adult male offspring. In 
      contrast, while ND-fed females from BUAL group were smaller and leaner than their 
      sham-littermates, WD consumption resulted in excess weight gain, fat 
      accumulation, and visceral adiposity. Moreover, WD increased plasma triglycerides 
      and cholesterol in the BUAL-treated female offspring without any effect on sham 
      littermates. These results demonstrate that reduced uterine artery blood flow 
      during late pregnancy in rodents can impact body composition in the offspring in 
      a sex-dependent manner, and these effects may be exacerbated by postnatal chronic 
      WD consumption.
FAU - Jahandideh, Forough
AU  - Jahandideh F
AUID- ORCID: 0000-0001-9731-0854
AD  - Department of Anesthesiology & Pain Medicine, University of Alberta, Edmonton, 
      Alberta, Canada.
AD  - Women and Children's Health Research Institute, University of Alberta, Edmonton, 
      Alberta, Canada.
FAU - Bourque, Stephane L
AU  - Bourque SL
AD  - Department of Anesthesiology & Pain Medicine, University of Alberta, Edmonton, 
      Alberta, Canada.
AD  - Women and Children's Health Research Institute, University of Alberta, Edmonton, 
      Alberta, Canada.
AD  - Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
FAU - Armstrong, Edward A
AU  - Armstrong EA
AD  - Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
FAU - Cherak, Stephana J
AU  - Cherak SJ
AD  - Department of Anesthesiology & Pain Medicine, University of Alberta, Edmonton, 
      Alberta, Canada.
FAU - Panahi, Sareh
AU  - Panahi S
AD  - Department of Anesthesiology & Pain Medicine, University of Alberta, Edmonton, 
      Alberta, Canada.
FAU - Macala, Kimberly F
AU  - Macala KF
AD  - Women and Children's Health Research Institute, University of Alberta, Edmonton, 
      Alberta, Canada.
AD  - Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
FAU - Davidge, Sandra T
AU  - Davidge ST
AD  - Women and Children's Health Research Institute, University of Alberta, Edmonton, 
      Alberta, Canada.
AD  - Department of Obstetrics and Gynecology, University of Alberta, Edmonton, 
      Alberta, Canada.
FAU - Yager, Jerome Y
AU  - Yager JY
AD  - Women and Children's Health Research Institute, University of Alberta, Edmonton, 
      Alberta, Canada. jyager@ualberta.ca.
AD  - Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada. 
      jyager@ualberta.ca.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200424
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Lipids)
SB  - IM
MH  - Adipocytes/pathology
MH  - Animals
MH  - Animals, Newborn
MH  - Body Composition
MH  - Body Weight
MH  - Cell Size
MH  - *Diet, Western
MH  - Female
MH  - Glucose Tolerance Test
MH  - Ligation
MH  - *Lipid Metabolism
MH  - Lipids/blood
MH  - Male
MH  - Obesity, Abdominal/blood/pathology
MH  - Organ Size
MH  - Pregnancy
MH  - Rats, Long-Evans
MH  - Uterine Artery/*pathology
PMC - PMC7181802
COIS- The authors declare no competing interests.
EDAT- 2020/04/26 06:00
MHDA- 2020/12/01 06:00
PMCR- 2020/04/24
CRDT- 2020/04/26 06:00
PHST- 2019/08/20 00:00 [received]
PHST- 2020/02/28 00:00 [accepted]
PHST- 2020/04/26 06:00 [entrez]
PHST- 2020/04/26 06:00 [pubmed]
PHST- 2020/12/01 06:00 [medline]
PHST- 2020/04/24 00:00 [pmc-release]
AID - 10.1038/s41598-020-63392-y [pii]
AID - 63392 [pii]
AID - 10.1038/s41598-020-63392-y [doi]
PST - epublish
SO  - Sci Rep. 2020 Apr 24;10(1):6926. doi: 10.1038/s41598-020-63392-y.