PMID- 32333100
OWN - NLM
STAT- MEDLINE
DCOM- 20210322
LR  - 20210322
IS  - 1863-2661 (Electronic)
IS  - 1863-2653 (Linking)
VI  - 225
IP  - 5
DP  - 2020 Jun
TI  - Brain-wide resting-state connectivity regulation by the hippocampus and medial 
      prefrontal cortex is associated with fluid intelligence.
PG  - 1587-1600
LID - 10.1007/s00429-020-02077-8 [doi]
AB  - The connectivity hub property of the hippocampus (HIP) and the medial prefrontal 
      cortex (MPFC) is essential for their widespread involvement in cognition; 
      however, the cooperation mechanism between them is far from clear. Herein, using 
      resting-state functional MRI and Gaussian Bayesian network to describe the 
      directed organizing architecture of the HIP-MPFC pathway with regions in the 
      brain, we demonstrated that the HIP and the MPFC have central roles as the 
      driving hub and aggregating hub, respectively. The status of the HIP and the MPFC 
      is dominant in communications between the HIP and the default-mode network, 
      between the HIP and core neurocognitive networks, including the default-mode, 
      frontoparietal, and salience networks, and between brain-wide representative 
      regions, suggesting a strong and robust central position of the two regions in 
      regulating the dynamics of large-scale brain activity. Furthermore, we found that 
      the directed connectivity and flow from the right HIP to the MPFC is 
      significantly linked to fluid intelligence. Together, these results clarify the 
      different roles of the HIP and the MPFC that jointly contribute to network 
      dynamics and cognitive ability from a data-driven insight via the use of the 
      directed connectivity method.
FAU - Li, Rui
AU  - Li R
AD  - CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China. 
      lir@psych.ac.cn.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China. lir@psych.ac.cn.
FAU - Zhang, Jing
AU  - Zhang J
AD  - Department of Psychology, Renmin University of China, Beijing, China.
FAU - Wu, Xia
AU  - Wu X
AD  - College of Information Science and Technology, Beijing Normal University, 
      Beijing, China.
FAU - Wen, Xiaotong
AU  - Wen X
AD  - Department of Psychology, Renmin University of China, Beijing, China.
FAU - Han, Buxin
AU  - Han B
AD  - CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
LA  - eng
GR  - Project No. 2018/The fund for building world-class universities (disciplines) of 
      Renmin University of China/
PT  - Journal Article
DEP - 20200424
PL  - Germany
TA  - Brain Struct Funct
JT  - Brain structure & function
JID - 101282001
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bayes Theorem
MH  - Brain Mapping
MH  - Default Mode Network/physiology
MH  - Female
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Intelligence/*physiology
MH  - Intelligence Tests
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Models, Neurological
MH  - Neural Pathways/physiology
MH  - Prefrontal Cortex/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Connectivity
OT  - Hippocampus
OT  - Intelligence
OT  - Medial prefrontal
OT  - Resting state
EDAT- 2020/04/26 06:00
MHDA- 2021/03/23 06:00
CRDT- 2020/04/26 06:00
PHST- 2019/10/24 00:00 [received]
PHST- 2020/04/18 00:00 [accepted]
PHST- 2020/04/26 06:00 [pubmed]
PHST- 2021/03/23 06:00 [medline]
PHST- 2020/04/26 06:00 [entrez]
AID - 10.1007/s00429-020-02077-8 [pii]
AID - 10.1007/s00429-020-02077-8 [doi]
PST - ppublish
SO  - Brain Struct Funct. 2020 Jun;225(5):1587-1600. doi: 10.1007/s00429-020-02077-8. 
      Epub 2020 Apr 24.