PMID- 32333593
OWN - NLM
STAT- MEDLINE
DCOM- 20210510
LR  - 20210510
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 75
IP  - 3
DP  - 2020
TI  - High Plasma Resistin Levels Portend the Insulin Resistance-Associated 
      Susceptibility to Early Cognitive Decline in Patients with Type 2 Diabetes 
      Mellitus.
PG  - 807-815
LID - 10.3233/JAD-200074 [doi]
AB  - BACKGROUND: Metabolic disorders, including insulin resistance, obesity, and 
      hyperlipidemia occur frequently prior to hyperglycemia in patients with type 2 
      diabetes mellitus (T2DM) and cause mild cognitive impairment (MCI). OBJECTIVE: We 
      investigated the involvement of resistin in these metabolic abnormalities 
      contributes to MCI in patients with T2DM. METHODS: A total of 138 hospitalized 
      patients with T2DM were enrolled and categorized into MCI and non-MCI groups 
      according to the Montreal Cognitive Assessment (MoCA) score. Metabolic indicators 
      and cognitive state were assessed, and plasma resistin levels were determined by 
      ELISA. RESULTS: The resistin levels and homeostasis model assessment of insulin 
      resistance (HOMA-IR) scores of MCI and gender-stratified subgroups were 
      significantly higher than those of controls without MCI (all p < 0.01). 
      Correlation analysis showed that the resistin level was negatively associated 
      with majority of cognitive domains, e.g., MoCA (r = -0.693, p < 0.001) and 
      Mini-Mental State Examination (r = -0.571, p < 0.001), and was related to HOMA-IR 
      (r = 0.667, p < 0.001) but not to obesity and lipid indices. Multivariable 
      regression analysis indicated that resistin (beta= -0.675, p < 0.001) and 
      educational level (beta= 0.177, p = 0.003) were independent risk factors of MoCA in 
      patients with T2DM. CONCLUSIONS: High plasma resistin levels portend the insulin 
      resistance-related susceptibility to early cognitive decline in Chinese patients 
      with T2DM. The involvement of this adipokine in other metabolic disorders leading 
      to diabetic MCI and its clinical value for early disease screening must be 
      further studied.
FAU - Wang, Chenchen
AU  - Wang C
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Huang, Xi
AU  - Huang X
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
FAU - Tian, Sai
AU  - Tian S
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Huang, Rong
AU  - Huang R
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Guo, Dan
AU  - Guo D
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Lin, Hongyan
AU  - Lin H
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Wang, Jiaqi
AU  - Wang J
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Wang, Shaohua
AU  - Wang S
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Biomarkers)
RN  - 0 (RETN protein, human)
RN  - 0 (Resistin)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Cognitive Dysfunction/*blood/*etiology
MH  - Diabetes Mellitus, Type 2/*blood/*complications
MH  - Female
MH  - Humans
MH  - *Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Resistin/*blood
MH  - Risk Factors
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - insulin resistance
OT  - mild cognitive impairment
OT  - resistin
OT  - type 2 diabetes
EDAT- 2020/04/26 06:00
MHDA- 2021/05/11 06:00
CRDT- 2020/04/26 06:00
PHST- 2020/04/26 06:00 [pubmed]
PHST- 2021/05/11 06:00 [medline]
PHST- 2020/04/26 06:00 [entrez]
AID - JAD200074 [pii]
AID - 10.3233/JAD-200074 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2020;75(3):807-815. doi: 10.3233/JAD-200074.