PMID- 32336232
OWN - NLM
STAT- MEDLINE
DCOM- 20210408
LR  - 20210408
IS  - 1524-4563 (Electronic)
IS  - 0194-911X (Linking)
VI  - 75
IP  - 6
DP  - 2020 Jun
TI  - Adults With Type 2 Diabetes Mellitus Exhibit a Greater Exercise-Induced Increase 
      in Arterial Stiffness and Vessel Hemodynamics.
PG  - 1565-1573
LID - 10.1161/HYPERTENSIONAHA.120.14778 [doi]
AB  - Individuals with type 2 diabetes mellitus (T2DM) have a greater blood pressure 
      (BP) response to acute maximal exercise compared to those without T2DM; however, 
      whether they exhibit a different arterial stiffness response to maximal exercise 
      has yet to be explored. Adults with (n=66) and without T2DM (n=61) underwent an 
      arterial stress test: at rest and immediately postexercise, carotid-femoral pulse 
      wave velocity, the gold standard measure of arterial stiffness, brachial BP, 
      heart rate, and other hemodynamic measurements were assessed. Linear regression 
      models were used to evaluate between-group differences at rest, and the response 
      to exercise (postexercise value), adjusting for covariates including BP and heart 
      rate when relevant, and the corresponding baseline value of each parameter. All 
      participants (mean+/-SD: age 59.3+/-10.6 years; body mass index 31.2+/-3.9 kg/m(2)) had 
      hypertension (mean BP 130+/-14/80+/-9 mm Hg). At rest, participants with T2DM had 
      significantly higher carotid-femoral pulse wave velocity (10.3+/-2.7 versus 9.1+/-1.9 
      m/s), heart rate (69+/-11 versus 66+/-10 beats/min), and lower diastolic BP (79+/-9 
      versus 83+/-9 mm Hg), but systolic BP (129+/-15 versus 131+/-13 mm Hg) was similar. In 
      response to exercise, participants with T2DM showed greater increases in 
      carotid-femoral pulse wave velocity (1.6 [95% CI, 0.4-2.9 m/s]) and systolic BP 
      (9 [95% CI, 1-17 mm Hg]) than participants without T2DM. A greater proportion of 
      participants with T2DM had a hypertensive response to exercise compared to 
      participants without T2DM (n=23, 35% versus n=11, 18%; P=0.033). By incorporating 
      exercise as a vascular stressor, we provide evidence of a greater increase in 
      arterial stiffness in individuals with T2DM, independently of resting arterial 
      stiffness, and the BP postexercise.
FAU - Cooke, Alexandra B
AU  - Cooke AB
AD  - From the Department of Medicine, McGill University Health Centre (A.B.C., K.D., 
      S.S.D.), McGill University, Montreal, QC, Canada.
AD  - Centre for Outcomes Research and Evaluation (CORE), Research Institute of the 
      McGill University Health Centre (A.B.C., K.D.), McGill University, Montreal, QC, 
      Canada.
FAU - Dasgupta, Kaberi
AU  - Dasgupta K
AD  - From the Department of Medicine, McGill University Health Centre (A.B.C., K.D., 
      S.S.D.), McGill University, Montreal, QC, Canada.
AD  - Centre for Outcomes Research and Evaluation (CORE), Research Institute of the 
      McGill University Health Centre (A.B.C., K.D.), McGill University, Montreal, QC, 
      Canada.
FAU - Spronck, Bart
AU  - Spronck B
AD  - Department of Biomedical Engineering, School of Engineering and Applied Science, 
      Yale University, New Haven, CT (B.S.).
AD  - Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, 
      Maastricht University, the Netherlands (B.S.).
FAU - Sharman, James E
AU  - Sharman JE
AD  - Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia 
      (J.E.S.).
FAU - Daskalopoulou, Stella S
AU  - Daskalopoulou SS
AD  - From the Department of Medicine, McGill University Health Centre (A.B.C., K.D., 
      S.S.D.), McGill University, Montreal, QC, Canada.
LA  - eng
GR  - MOP-79275/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200427
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
SB  - IM
MH  - Arterial Pressure/physiology
MH  - Blood Pressure/physiology
MH  - Body Mass Index
MH  - Carotid-Femoral Pulse Wave Velocity/*methods
MH  - *Diabetes Mellitus, Type 2/complications/physiopathology
MH  - Exercise/*physiology
MH  - Exercise Test/adverse effects/*methods
MH  - Female
MH  - Heart Rate/physiology
MH  - Hemodynamics
MH  - Humans
MH  - *Hypertension/diagnosis/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Vascular Stiffness/*physiology
OTO - NOTNLM
OT  - blood pressure
OT  - diabetes mellitus
OT  - exercise
OT  - heart rate
OT  - vascular stiffness
EDAT- 2020/04/28 06:00
MHDA- 2021/04/10 06:00
CRDT- 2020/04/28 06:00
PHST- 2020/04/28 06:00 [pubmed]
PHST- 2021/04/10 06:00 [medline]
PHST- 2020/04/28 06:00 [entrez]
AID - 10.1161/HYPERTENSIONAHA.120.14778 [doi]
PST - ppublish
SO  - Hypertension. 2020 Jun;75(6):1565-1573. doi: 10.1161/HYPERTENSIONAHA.120.14778. 
      Epub 2020 Apr 27.