PMID- 32336641
OWN - NLM
STAT- MEDLINE
DCOM- 20201117
LR  - 20201117
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 78
DP  - 2020 Aug
TI  - Plasma cytokine profile in synucleinophaties with dementia.
PG  - 323-326
LID - S0967-5868(20)30366-0 [pii]
LID - 10.1016/j.jocn.2020.04.058 [doi]
AB  - Immune response may play a pivotal role in the pathogenesis of the common 
      synucleinopathy as Parkinson's disease (PD) and could be mediated with the 
      accumulation of neurotoxic alpha-synuclein. There is limited evidence for immune 
      response in another synucleinopathy as dementia with Lewy bodies (DLB). Recent 
      data suggest that immune response may contribute to cognitive impairment. We 
      aimed to estimate plasma cytokine profile in patients with synucleinopathies with 
      dementia (PD dementia (PDD), DLB). Plasma cytokine levels (interferon-gamma 
      (IFN-gamma), interleukin (IL)-4 (IL-4), IL-6, IL-10, tumor necrosis factor alpha 
      (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1)). were estimated in 16 
      patients with DLB, 19 patients with PDD, 28 patients with PD without dementia 
      (PD) and 19 individuals without neurological disorders (controls) using Luminex 
      array system. Cognitive status was assessed with the Mini-Mental State 
      Examination (MMSE). TNF-alpha and IL-6 plasma levels were elevated in patients 
      with synucleinopathies with dementia (DLB, PDD) compared to controls and IL-10 
      plasma level was increased in PDD compared to controls (p < 0.05). IFN-gamma 
      levels were decreased in PD and PDD patients compared to controls (p < 0.001, 
      p = 0.026, respectively) and in PD patients than in DLB patients (p = 0.032). 
      Patients with PD, PDD, and DLB were characterized by increased plasma levels of 
      MCP-1 compared to controls (p < 0.001). At the same time, no differences in 
      TNF-alpha, IL-10, IL-6 plasma levels in PD patients compared to controls were 
      found. Our study demonstrated more pronounced immune response in 
      synucleinopathies associated with dementia compared to PD without demetia.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Usenko, T S
AU  - Usenko TS
AD  - Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National 
      Research Centre, <<Kurchatov Institute>>, Gatchina, Russia; Pavlov First Saint 
      Petersburg State Medical University, Saint-Petersburg, Russia. Electronic 
      address: usenko_ts@pnpi.nrcki.ru.
FAU - Nikolaev, M A
AU  - Nikolaev MA
AD  - Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National 
      Research Centre, <<Kurchatov Institute>>, Gatchina, Russia; Pavlov First Saint 
      Petersburg State Medical University, Saint-Petersburg, Russia.
FAU - Miliukhina, I V
AU  - Miliukhina IV
AD  - Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National 
      Research Centre, <<Kurchatov Institute>>, Gatchina, Russia; Pavlov First Saint 
      Petersburg State Medical University, Saint-Petersburg, Russia; Institute of 
      Experimental Medicine, Saint-Petersburg, Russia.
FAU - Bezrukova, A I
AU  - Bezrukova AI
AD  - Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National 
      Research Centre, <<Kurchatov Institute>>, Gatchina, Russia.
FAU - Senkevich, K A
AU  - Senkevich KA
AD  - Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National 
      Research Centre, <<Kurchatov Institute>>, Gatchina, Russia; Pavlov First Saint 
      Petersburg State Medical University, Saint-Petersburg, Russia; Institute of 
      Experimental Medicine, Saint-Petersburg, Russia.
FAU - Gomzyakova, N A
AU  - Gomzyakova NA
AD  - V.M. Bekhterevs National Medical Research Center Psychiatry and Neurology, 
      Saint-Petersburg, Russia.
FAU - Beltceva, Y A
AU  - Beltceva YA
AD  - V.M. Bekhterevs National Medical Research Center Psychiatry and Neurology, 
      Saint-Petersburg, Russia.
FAU - Zalutskaya, N M
AU  - Zalutskaya NM
AD  - V.M. Bekhterevs National Medical Research Center Psychiatry and Neurology, 
      Saint-Petersburg, Russia.
FAU - Gracheva, E V
AU  - Gracheva EV
AD  - Institute of Experimental Medicine, Saint-Petersburg, Russia.
FAU - Timofeeva, A A
AU  - Timofeeva AA
AD  - Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russia.
FAU - Petrova, O A
AU  - Petrova OA
AD  - Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russia; 
      Saint-Petersburg Pasteur Institute, Saint-Petersburg, Russia.
FAU - Semenov, A V
AU  - Semenov AV
AD  - Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russia; 
      Saint-Petersburg Pasteur Institute, Saint-Petersburg, Russia.
FAU - Lubimova, N E
AU  - Lubimova NE
AD  - Saint-Petersburg Pasteur Institute, Saint-Petersburg, Russia.
FAU - Totolyan, A A
AU  - Totolyan AA
AD  - Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russia; 
      Saint-Petersburg Pasteur Institute, Saint-Petersburg, Russia.
FAU - Pchelina, S N
AU  - Pchelina SN
AD  - Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National 
      Research Centre, <<Kurchatov Institute>>, Gatchina, Russia; Pavlov First Saint 
      Petersburg State Medical University, Saint-Petersburg, Russia; Institute of 
      Experimental Medicine, Saint-Petersburg, Russia.
LA  - eng
PT  - Journal Article
DEP - 20200423
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (IFNG protein, human)
RN  - 0 (IL10 protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chemokine CCL2/blood
MH  - Cytokines/*blood
MH  - Dementia/blood/*etiology/immunology
MH  - Female
MH  - Humans
MH  - Interferon-gamma/blood
MH  - Interleukin-10/blood
MH  - Interleukin-6/blood
MH  - Lewy Body Disease/blood/immunology
MH  - Mental Status and Dementia Tests
MH  - Middle Aged
MH  - Parkinson Disease/blood/complications/immunology
MH  - Synucleinopathies/blood/complications/*immunology
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - Cytokines
OT  - Parkinson's disease
OT  - Plasma
OT  - dementia with Lewy bodies
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/04/28 06:00
MHDA- 2020/11/18 06:00
CRDT- 2020/04/28 06:00
PHST- 2020/02/20 00:00 [received]
PHST- 2020/04/11 00:00 [accepted]
PHST- 2020/04/28 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2020/04/28 06:00 [entrez]
AID - S0967-5868(20)30366-0 [pii]
AID - 10.1016/j.jocn.2020.04.058 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2020 Aug;78:323-326. doi: 10.1016/j.jocn.2020.04.058. Epub 2020 
      Apr 23.