PMID- 32336668
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20231111
IS  - 2213-2317 (Electronic)
IS  - 2213-2317 (Linking)
VI  - 34
DP  - 2020 Jul
TI  - Redox toxicology of environmental chemicals causing oxidative stress.
PG  - 101475
LID - S2213-2317(19)31511-3 [pii]
LID - 10.1016/j.redox.2020.101475 [doi]
LID - 101475
AB  - Living organisms are surrounded with heavy metals such as methylmercury, 
      manganese, cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin 
      and paraquat, or atmospheric pollutants such as quinone. Extensive studies have 
      demonstrated a strong link between environmental pollutants and human health. 
      Redox toxicity is proposed as one of the main mechanisms of chemical-induced 
      pathology in humans. Acting as both a sensor of oxidative stress and a positive 
      regulator of antioxidants, the nuclear factor erythroid 2-related factor 2 (NRF2) 
      has attracted recent attention. However, the role NRF2 plays in environmental 
      pollutant-induced toxicity has not been systematically addressed. Here, we 
      characterize NRF2 function in response to various pollutants, such as metals, 
      pesticides and atmospheric quinones. NRF2 related signaling pathways and 
      epigenetic regulations are also reviewed.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Zheng, Fuli
AU  - Zheng F
AD  - Department of Preventive Medicine, School of Public Health, Fujian Medical 
      University, Fuzhou, Fujian, 350122, China; Department of Molecular Pharmacology, 
      Albert Einstein College of Medicine, Forchheimer 209, 1300 Morris Park Avenue, 
      Bronx, NY, 10461, United States. Electronic address: f.zheng@fjmu.edu.cn.
FAU - Goncalves, Filipe Marques
AU  - Goncalves FM
AD  - Department of Molecular Pharmacology, Albert Einstein College of Medicine, 
      Forchheimer 209, 1300 Morris Park Avenue, Bronx, NY, 10461, United States.
FAU - Abiko, Yumi
AU  - Abiko Y
AD  - Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba, 
      Tsukuba, 305-8575, Japan.
FAU - Li, Huangyuan
AU  - Li H
AD  - Department of Preventive Medicine, School of Public Health, Fujian Medical 
      University, Fuzhou, Fujian, 350122, China. Electronic address: lhy@fjmu.edu.cn.
FAU - Kumagai, Yoshito
AU  - Kumagai Y
AD  - Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba, 
      Tsukuba, 305-8575, Japan. Electronic address: yk-em-tu@md.tsukuba.ac.jp.
FAU - Aschner, Michael
AU  - Aschner M
AD  - Department of Molecular Pharmacology, Albert Einstein College of Medicine, 
      Forchheimer 209, 1300 Morris Park Avenue, Bronx, NY, 10461, United States. 
      Electronic address: michael.aschner@einsteinmed.org.
LA  - eng
GR  - R01 ES007331/ES/NIEHS NIH HHS/United States
GR  - R01 ES010563/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200418
PL  - Netherlands
TA  - Redox Biol
JT  - Redox biology
JID - 101605639
RN  - 0 (Antioxidants)
RN  - 0 (Metals, Heavy)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Pesticides)
SB  - IM
MH  - Antioxidants
MH  - Humans
MH  - *Metals, Heavy/toxicity
MH  - NF-E2-Related Factor 2/genetics/metabolism
MH  - Oxidation-Reduction
MH  - Oxidative Stress
MH  - *Pesticides/toxicity
PMC - PMC7327986
OTO - NOTNLM
OT  - Air pollutants
OT  - Epigenetic modifications
OT  - Heavy metals
OT  - NRF2
OT  - Pesticides
OT  - Redox signaling pathways
COIS- Declaration of competing interest We declare that we have no financial and 
      personal relationships with other people or organizations that can 
      inappropriately influence our work, there is no professional or other personal 
      interest of any nature or kind in any product, service and/or company that could 
      be construed as influencing the position presented in, or the review of, the 
      manuscript entitled "Redox Toxicology of Environmental Chemicals Causing 
      Oxidative Stress".
EDAT- 2020/04/28 06:00
MHDA- 2021/06/22 06:00
PMCR- 2020/04/18
CRDT- 2020/04/28 06:00
PHST- 2019/12/04 00:00 [received]
PHST- 2020/02/18 00:00 [revised]
PHST- 2020/02/20 00:00 [accepted]
PHST- 2020/04/28 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/04/28 06:00 [entrez]
PHST- 2020/04/18 00:00 [pmc-release]
AID - S2213-2317(19)31511-3 [pii]
AID - 101475 [pii]
AID - 10.1016/j.redox.2020.101475 [doi]
PST - ppublish
SO  - Redox Biol. 2020 Jul;34:101475. doi: 10.1016/j.redox.2020.101475. Epub 2020 Apr 
      18.