PMID- 32337849
OWN - NLM
STAT- MEDLINE
DCOM- 20211022
LR  - 20211204
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Print)
IS  - 1751-7885 (Linking)
VI  - 15
IP  - 3
DP  - 2021 Jun
TI  - Structure of positive psychotic symptoms in individuals at clinical high risk for 
      psychosis.
PG  - 505-512
LID - 10.1111/eip.12969 [doi]
AB  - AIM: Positive symptoms are a critical dimension of psychopathology in psychotic 
      disorders and are used as a criterion for diagnosis across the psychosis 
      continuum. Although initially considered as one dimension, there is evidence for 
      multidimensionality within positive symptoms. The positive symptom structure has 
      not been examined in individuals at clinical high risk (CHR) for psychosis. 
      Knowledge of the dimensional structure of positive symptoms within CHR may 
      contribute to our understanding of the aetiology and trajectory of this key facet 
      of psychosis. METHOD: Exploratory factor analysis (EFA) was conducted on the 
      Prodromal Questionnaire-Brief for 183 individuals meeting CHR criteria. Internal 
      consistency was examined to determine the hierarchical structure of the data and 
      alternative models were compared. RESULTS: EFA revealed a three factor model, 
      grouping in to: perceptual abnormalities, grandiose/unusual delusions and 
      persecutory/thought delusions, with a general factor accounting for 56% of the 
      variance. Confirmatory factor analysis showed that a hierarchical model was the 
      best fit. One item referring to nihilistic thoughts did not load on any factor. 
      CONCLUSION: There is a clear three-dimensional model, distinguishing perceptual 
      abnormalities, and two subgroups of delusions in CHR individuals. The factors are 
      similar to those found in psychotic disorders. The identification and comparison 
      of symptomatic models is useful given the prominent role positive symptoms play 
      in diagnosis, and is crucial to our understanding of the clinical progression of 
      psychosis. This work may provide a useful tool for future studies examining 
      correlations with varying symptom factors and disease progression in CHR.
CI  - (c) 2020 John Wiley & Sons Australia, Ltd.
FAU - Azis, Matilda
AU  - Azis M
AUID- ORCID: 0000-0001-8164-0357
AD  - Department of Psychology, Northwestern University, Illinois, USA.
AD  - Department of Psychiatry, Northwestern University, Illinois, USA.
AD  - Department of Medical Social Sciences, Northwestern University, Illinois, USA.
AD  - Institute for Policy Research, Northwestern University, Illinois, USA.
AD  - Institute for Innovations in Developmental Sciences, Northwestern University, 
      Illinois, USA.
FAU - Rouhakhtar, Pamela Rakhshan
AU  - Rouhakhtar PR
AD  - Department of Psychology, University of Maryland, Baltimore County, Maryland, 
      USA.
FAU - Schiffman, Jason E
AU  - Schiffman JE
AD  - Department of Psychology, University of Maryland, Baltimore County, Maryland, 
      USA.
FAU - Ellman, Lauren M
AU  - Ellman LM
AD  - Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA.
FAU - Strauss, Gregory P
AU  - Strauss GP
AD  - Department of Psychology, University of Georgia, Athens, Georgia, USA.
FAU - Mittal, Vijay A
AU  - Mittal VA
AD  - Department of Psychology, Northwestern University, Illinois, USA.
LA  - eng
GR  - R01 MH112613/MH/NIMH NIH HHS/United States
GR  - R33 MH103231/MH/NIMH NIH HHS/United States
GR  - R34 MH110506/MH/NIMH NIH HHS/United States
GR  - R21 MH103231/MH/NIMH NIH HHS/United States
GR  - R01 MH112545/MH/NIMH NIH HHS/United States
GR  - R01 MH094650/MH/NIMH NIH HHS/United States
GR  - R21 MH110374/MH/NIMH NIH HHS/United States
GR  - R01 MH112612/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200426
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
SB  - IM
MH  - Delusions
MH  - Disease Progression
MH  - Humans
MH  - *Prodromal Symptoms
MH  - *Psychotic Disorders/diagnosis
PMC - PMC8638562
MID - NIHMS1757745
OTO - NOTNLM
OT  - clinical high risk for psychosis
OT  - factor analysis
OT  - positive symptoms
OT  - psychosis
OT  - schizophrenia
EDAT- 2020/04/28 06:00
MHDA- 2021/11/19 06:00
PMCR- 2021/12/02
CRDT- 2020/04/28 06:00
PHST- 2020/02/28 00:00 [revised]
PHST- 2019/11/25 00:00 [received]
PHST- 2020/04/02 00:00 [accepted]
PHST- 2020/04/28 06:00 [pubmed]
PHST- 2021/11/19 06:00 [medline]
PHST- 2020/04/28 06:00 [entrez]
PHST- 2021/12/02 00:00 [pmc-release]
AID - 10.1111/eip.12969 [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2021 Jun;15(3):505-512. doi: 10.1111/eip.12969. Epub 
      2020 Apr 26.