PMID- 32339688 OWN - NLM STAT- MEDLINE DCOM- 20201109 LR - 20221207 IS - 1615-5947 (Electronic) IS - 0890-5096 (Linking) VI - 68 DP - 2020 Oct TI - Endovascular Therapy Provides Similar Results of Bypass Graft Surgery in the Treatment of Infrainguinal Multilevel Arterial Disease in Patients with Chronic Limb-Threatening Ischemia in All GLASS Stages. PG - 400-408 LID - S0890-5096(20)30347-2 [pii] LID - 10.1016/j.avsg.2020.04.028 [doi] AB - BACKGROUND: Extensive infrainguinal arterial disease still pose a challenge for technical and clinical success of percutaneous angioplasty. The purpose of this study was to compare the results of concomitant femoropopliteal and infrapopliteal percutaneous angioplasty/stenting (PTA/S) with distal bypass graft surgery (BGS) in patients with chronic limb-threatening ischemia (CLTI). METHOD: In a single-center retrospective investigation between 2011 and 2017, 668 revascularization procedures for CLTI were reviewed. Concomitant femoropopliteal and infrapopliteal disease was identified in 153 CLTI patients, treated with BGS (48) using autogenous veins as substitute or PTA/S in a single procedure (105). A subgroup of patients with complex, extensive arterial lesions (GLASS stage III) received additional analysis. Primary outcomes were limb salvage and survival. RESULTS: The mean follow-up time was 21.4 months. Patients treated with PTA/S were significantly older and with predominance of females, diabetes and chronic kidney disease. Smoking was more common in patients treated with BGS. The BGS group showed a 36-month survival rate of 73.4%, whereas the PTA/S group presented a survival of 61.3% in the same interval (P = 0.25). The 36-month cumulative limb salvage rate was 53.3 and 59.7% for BGS and PTA/S, respectively (P = 0.24). For GLASS stage III patients, 36-month limb salvage rates were 54.4% for the PTA/S group and 50.2% for the BGS group (P = 0.29). Multivariate analysis pointed poor runoff status (all endovascular patients) and diabetes (GLASS III endovascular patients) as risk factors for limb loss. CONCLUSION: PTA/S and BGS presented similar results of limb salvage and survival in the treatment of concomitant femoropopliteal and infrapopliteal arterial disease in patients with CLTI, even for patients with extensive and complex arterial disease. CI - Copyright (c) 2020 Elsevier Inc. All rights reserved. FAU - Casella, Ivan Benaduce AU - Casella IB AD - Vascular Surgery Division, Clinics Hospital of the Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: ivan.c@hc.fm.usp.br. FAU - Sartori, Camila Holanda AU - Sartori CH AD - Vascular Surgery Division, Clinics Hospital of the Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil. FAU - Faustino, Carolina Brito AU - Faustino CB AD - Vascular Surgery Division, Clinics Hospital of the Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil. FAU - Vieira Mariz, Maria Paula AU - Vieira Mariz MP AD - Vascular Surgery Division, Clinics Hospital of the Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil. FAU - Presti, Calogero AU - Presti C AD - Vascular Surgery Division, Clinics Hospital of the Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil. FAU - Puech-Leao, Pedro AU - Puech-Leao P AD - Vascular Surgery Division, Clinics Hospital of the Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil. FAU - De Luccia, Nelson AU - De Luccia N AD - Vascular Surgery Division, Clinics Hospital of the Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil. LA - eng PT - Comparative Study PT - Journal Article DEP - 20200425 PL - Netherlands TA - Ann Vasc Surg JT - Annals of vascular surgery JID - 8703941 SB - IM MH - Aged MH - Amputation, Surgical MH - *Angioplasty/adverse effects/instrumentation/mortality MH - Chronic Disease MH - Female MH - Femoral Artery/diagnostic imaging/physiopathology/*surgery MH - Humans MH - Ischemia/diagnostic imaging/mortality/physiopathology/*therapy MH - Limb Salvage MH - Male MH - Middle Aged MH - Peripheral Arterial Disease/diagnostic imaging/mortality/physiopathology/*therapy MH - Popliteal Artery/diagnostic imaging/physiopathology/*surgery MH - Retrospective Studies MH - Risk Factors MH - Saphenous Vein/*transplantation MH - Stents MH - Time Factors MH - Treatment Outcome MH - *Vascular Grafting/adverse effects/mortality MH - Vascular Patency EDAT- 2020/04/28 06:00 MHDA- 2020/11/11 06:00 CRDT- 2020/04/28 06:00 PHST- 2020/04/07 00:00 [received] PHST- 2020/04/13 00:00 [revised] PHST- 2020/04/14 00:00 [accepted] PHST- 2020/04/28 06:00 [pubmed] PHST- 2020/11/11 06:00 [medline] PHST- 2020/04/28 06:00 [entrez] AID - S0890-5096(20)30347-2 [pii] AID - 10.1016/j.avsg.2020.04.028 [doi] PST - ppublish SO - Ann Vasc Surg. 2020 Oct;68:400-408. doi: 10.1016/j.avsg.2020.04.028. Epub 2020 Apr 25.