PMID- 32340698
OWN - NLM
STAT- MEDLINE
DCOM- 20211008
LR  - 20211008
IS  - 1558-3163 (Electronic)
IS  - 0889-857X (Linking)
VI  - 46
IP  - 2
DP  - 2020 May
TI  - What Does Human Leukocyte Antigen B27 Have to Do with Spondyloarthritis?
PG  - 225-239
LID - S0889-857X(20)30002-8 [pii]
LID - 10.1016/j.rdc.2020.01.002 [doi]
AB  - Human leukocyte antigen (HLA) B27 is the key laboratory parameter for axial 
      spondyloarthritis (axSpA). Its prevalence is variable across different geographic 
      zones and ethnicities, and often mirrors the prevalence of axSpA. HLA-B27 plays a 
      role in axSpA physiopathology. It is correlated with spondyloarthritis phenotype 
      with a consistent positive association with family history, early disease onset, 
      shorter diagnostic delay, hip involvement, and acute anterior uveitis. HLA-B27 
      has a pivotal role in many referral strategies. However, these strategies were 
      developed in European populations and need to be evaluated in populations with 
      lower HLA-B27 background prevalence, and where additional parameters might be 
      needed.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Fahed, Hanna
AU  - Fahed H
AD  - Department of Rheumatology, Saint-Joseph University, Hotel-Dieu de France 
      Hospital, BP 166830, Achrafieh, Beirut, Lebanon.
FAU - Mauro, Daniele
AU  - Mauro D
AD  - Division of Rheumatology, Department of Precision Medicine, University of 
      Campania "Luigi Vanvitelli", Via Sergio Pansini 5, Napoli 80131, Italy.
FAU - Ciccia, Francesco
AU  - Ciccia F
AD  - Division of Rheumatology, Department of Precision Medicine, University of 
      Campania "Luigi Vanvitelli", Via Sergio Pansini 5, Napoli 80131, Italy.
FAU - Ziade, Nelly R
AU  - Ziade NR
AD  - Department of Rheumatology, Saint-Joseph University, Hotel-Dieu de France 
      Hospital, BP 166830, Achrafieh, Beirut, Lebanon. Electronic address: 
      nelly.zoghbi@usj.edu.lb.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Rheum Dis Clin North Am
JT  - Rheumatic diseases clinics of North America
JID - 8708093
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - *HLA-B27 Antigen
MH  - Humans
MH  - Spondylarthritis/physiopathology
MH  - *Spondylarthropathies/physiopathology
OTO - NOTNLM
OT  - Diagnosis
OT  - Disease phenotype
OT  - Genetics
OT  - HLA-B27
OT  - Prognosis
OT  - Spondyloarthritis
COIS- Disclosure The authors have nothing to disclose.
EDAT- 2020/04/29 06:00
MHDA- 2021/10/09 06:00
CRDT- 2020/04/29 06:00
PHST- 2020/04/29 06:00 [entrez]
PHST- 2020/04/29 06:00 [pubmed]
PHST- 2021/10/09 06:00 [medline]
AID - S0889-857X(20)30002-8 [pii]
AID - 10.1016/j.rdc.2020.01.002 [doi]
PST - ppublish
SO  - Rheum Dis Clin North Am. 2020 May;46(2):225-239. doi: 10.1016/j.rdc.2020.01.002.