PMID- 32341645
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 1176-6336 (Print)
IS  - 1178-203X (Electronic)
IS  - 1176-6336 (Linking)
VI  - 16
DP  - 2020
TI  - Safety Profile of Musculoskeletal Contrast-Enhanced Ultrasound with Sulfur 
      Hexafluoride Contrast Agent.
PG  - 269-280
LID - 10.2147/TCRM.S235235 [doi]
AB  - PURPOSE: Muscle, bone and tendon regeneration depend on the microperfusion of the 
      corresponding tissue which can be quantified with contrast-enhanced ultrasound 
      (CEUS) using sulfur hexafluoride contrast agent (SonoVue((R))). This study 
      investigated the incidence of adverse events (AEs) in musculoskeletal patients 
      and gives an overview of musculoskeletal CEUS applications. PATIENTS AND METHODS: 
      Based on 13 studies in a standardized monocentric setting, a total of 2268 CEUS 
      examinations in 764 patients were performed and AEs due to the administration of 
      sulfur hexafluoride contrast agent were classified as either mild, moderate or 
      severe. RESULTS: No fatal events occurred. AEs were reported in three cases, of 
      which only one was classified as severe and two as mild. The total rate of all 
      AEs was 0.13% and 0.04% for severe AEs. CONCLUSION: The present analysis confirms 
      the safety of musculoskeletal CEUS using sulfur hexafluoride contrast agent with 
      a lower rate of AEs than that reported for other contrast agents even in elderly 
      patients with concomitant diseases.
CI  - (c) 2020 Fischer et al.
FAU - Fischer, Christian
AU  - Fischer C
AUID- ORCID: 0000-0002-3865-0610
AD  - Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Ultrasound Center, 
      HTRG - Heidelberg Trauma Research Group, Heidelberg University Hospital, 
      Heidelberg 69118, Germany.
FAU - Kunz, Pierre
AU  - Kunz P
AD  - Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Ultrasound Center, 
      HTRG - Heidelberg Trauma Research Group, Heidelberg University Hospital, 
      Heidelberg 69118, Germany.
FAU - Strauch, Marten
AU  - Strauch M
AD  - Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Ultrasound Center, 
      HTRG - Heidelberg Trauma Research Group, Heidelberg University Hospital, 
      Heidelberg 69118, Germany.
FAU - Weber, Marc-Andre
AU  - Weber MA
AUID- ORCID: 0000-0003-3918-8066
AD  - Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and 
      Neuroradiology, University Medical Center Rostock, Rostock 18057, Germany.
FAU - Doll, Julian
AU  - Doll J
AD  - Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Ultrasound Center, 
      HTRG - Heidelberg Trauma Research Group, Heidelberg University Hospital, 
      Heidelberg 69118, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200414
PL  - New Zealand
TA  - Ther Clin Risk Manag
JT  - Therapeutics and clinical risk management
JID - 101253281
PMC - PMC7166060
OTO - NOTNLM
OT  - CEUS
OT  - adverse events
OT  - contrast agents
OT  - contrast-enhanced ultrasound
OT  - musculoskeletal
OT  - sulfur hexafluoride
COIS- The authors report no conflicts of interest in this work.
EDAT- 2020/04/29 06:00
MHDA- 2020/04/29 06:01
PMCR- 2020/04/14
CRDT- 2020/04/29 06:00
PHST- 2019/10/18 00:00 [received]
PHST- 2020/03/09 00:00 [accepted]
PHST- 2020/04/29 06:00 [entrez]
PHST- 2020/04/29 06:00 [pubmed]
PHST- 2020/04/29 06:01 [medline]
PHST- 2020/04/14 00:00 [pmc-release]
AID - 235235 [pii]
AID - 10.2147/TCRM.S235235 [doi]
PST - epublish
SO  - Ther Clin Risk Manag. 2020 Apr 14;16:269-280. doi: 10.2147/TCRM.S235235. 
      eCollection 2020.