PMID- 32342940
OWN - NLM
STAT- MEDLINE
DCOM- 20210205
LR  - 20210205
IS  - 0126-8635 (Print)
IS  - 0126-8635 (Linking)
VI  - 42
IP  - 1
DP  - 2020 Apr
TI  - Metastatic alveolar rhabdomyosarcoma on the fine-needle aspiration cytology of 
      cervical lymph node in an elderly patient, with FISH confirmation: A case report.
PG  - 115-119
AB  - INTRODUCTION: Alveolar rhabdomyosarcoma (RMS) usually occurs in adolescents and 
      young adults, and most frequently arises in the extremities. CASE REPORT: We 
      present a rare case of metastatic alveolar RMS from a nasal primary to cervical 
      lymph nodes (LNs) in an elderly patient, diagnosed on the fine-needle aspiration 
      (FNA) biopsy. Smears showed malignant round cells featuring focal rhabdoid 
      appearance, with rhabdomyoblastic differentiation further supported by 
      immunocytochemical stains. Diagnosis of alveolar RMS was confirmed by 
      fluorescence in situ hybridization (FISH) identifying FOXO1 gene involvement with 
      dual colour break-apart probes at locus 13q14. DISCUSSION: The differential 
      diagnosis for a small round blue cell tumour in the elderly generally includes 
      metastatic small cell carcinoma, lymphoma, malignant melanoma, RMS, desmoplastic 
      small round cell tumour and Ewing's sarcoma/primitive neuroectodermal tumour. 
      Subtle morphological analysis and expression pattern of immunostaining for 
      skeletal muscle differentiation led to the diagnosis of RMS. Cytogenetic testing 
      on the FOXO1 gene rearrangement helps definite subtyping of alveolar RMS.
FAU - Zhao, Z
AU  - Zhao Z
AD  - Singapore General Hospital, Division of Pathology, Department of Anatomical 
      Pathology, Singapore. sathiyamoorthy.selvarajan@singhealth.com.sg.
FAU - Takano, A
AU  - Takano A
FAU - Lim, A S T
AU  - Lim AST
FAU - Lim, T H
AU  - Lim TH
FAU - Selvarajan, S
AU  - Selvarajan S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Malaysia
TA  - Malays J Pathol
JT  - The Malaysian journal of pathology
JID - 8101177
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/analysis
MH  - Biopsy, Fine-Needle
MH  - Cytodiagnosis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymph Nodes/pathology
MH  - Lymphatic Metastasis/*pathology
MH  - Nasal Cavity/*pathology
MH  - Nose Neoplasms/*diagnosis/pathology
MH  - Rhabdomyosarcoma, Alveolar/*diagnosis/pathology
EDAT- 2020/04/29 06:00
MHDA- 2021/02/07 06:00
CRDT- 2020/04/29 06:00
PHST- 2020/04/29 06:00 [entrez]
PHST- 2020/04/29 06:00 [pubmed]
PHST- 2021/02/07 06:00 [medline]
PST - ppublish
SO  - Malays J Pathol. 2020 Apr;42(1):115-119.