PMID- 3234416
OWN - NLM
STAT- MEDLINE
DCOM- 19890427
LR  - 20190510
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 9
IP  - 11
DP  - 1988 Nov
TI  - Functional status and left ventricular performance late after valve replacement 
      for aortic stenosis. Relation to preoperative data.
PG  - 1234-43
AB  - Relations between preoperative data and status at one- and 10-year control and 
      left ventricular performance (radionuclide angiocardiography) at follow-up 10-17 
      years (mean 12 years) after valve replacement (1965-73) for aortic stenosis were 
      studied. Marked improvements at one-year were noted for New York Heart 
      Association (NYHA) functional classes, cardiothorac index (CTI), and ECG 
      hypertrophy (Romhilt-Estes) score. One-year status did not influence that at 10 
      years. In 59 patients who were in NYHA class I at one year, class I was 
      maintained in 75% of those who were in class II preoperatively, compared with 47% 
      of those who had been in class III, and 23% of those who had been in class IV, (P 
      less than 0.05). The same relation to preoperative level was found for patients 
      with CTI less than or equal to 0.50 at one-year control. The ECG score did not 
      change after the first year. Left ventricular hypertrophy (ECG score greater than 
      or equal to 4) was present in 90% and 84% of the patients at one and 10 years, 
      respectively. Ejection fraction (EF) and peak filling rate (PFR) at follow-up 
      were (mean +/- SD) 65 +/- 13% and 3.14 +/- 1.05 end-diastolic volume s-1, 
      respectively; only 13 patients had a radionuclide study within the normal range 
      for all parameters measured. A normal study was found predominantly in patients 
      with complete regression of hypertrophy. Multiple linear regression models 
      incorporating preoperative data allowed calculation of predicted EF (65 +/- 9) 
      and PFR (3.17 +/- 0.92) which did not differ from the measured values. Functional 
      status and left ventricular systolic and diastolic performance late after the 
      operation depended closely on preoperative status. Improvements noted at one year 
      were only temporary in patients with preoperative advance disease. Normal left 
      ventricular performance late after valve replacement was related to complete 
      reversibility of hypertrophy. Our results argue for operation in minimally 
      symptomatic patients.
FAU - Lund, O
AU  - Lund O
AD  - Department of Thoracic and Cardiovascular Surgery, Skejby Sygehus/Aarhus 
      University Hospital, Denmark.
FAU - Jensen, F T
AU  - Jensen FT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aortic Valve Stenosis/pathology/*physiopathology/surgery
MH  - Female
MH  - Follow-Up Studies
MH  - *Heart Valve Prosthesis
MH  - Heart Ventricles/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Radionuclide Angiography
MH  - Time Factors
EDAT- 1988/11/01 00:00
MHDA- 1988/11/01 00:01
CRDT- 1988/11/01 00:00
PHST- 1988/11/01 00:00 [pubmed]
PHST- 1988/11/01 00:01 [medline]
PHST- 1988/11/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.eurheartj.a062435 [doi]
PST - ppublish
SO  - Eur Heart J. 1988 Nov;9(11):1234-43. doi: 
      10.1093/oxfordjournals.eurheartj.a062435.