PMID- 32344165
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240227
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 192
DP  - 2020 Apr 19
TI  - Disassembling and degradation of amyloid protein aggregates based on gold 
      nanoparticle-modified g-C(3)N(4).
PG  - 111051
LID - S0927-7765(20)30281-2 [pii]
LID - 10.1016/j.colsurfb.2020.111051 [doi]
AB  - Amyloid protein misfolds, abnormally aggregates and accumulates into amyloid 
      deposits which endanger tissue functions and are closely related to the 
      pathogenesis of many diseases including Type 2 Diabetes Mellitus (T2DM). There 
      are on-going efforts to find new methods or effective reagents to disassemble and 
      eliminate the existing amyloid aggregates. Herein, we showed that a gold 
      nanoparticle-modified quasi-2D nanomaterial, Au/g-C(3)N(4,) could efficiently 
      degrade preformed amyloid aggregates. Furthermore, the scavenger experiment 
      revealed this photodegradation effect was depended on the induced oxygen 
      radicals, particularly hydroxyl radical. The new finding in this work could 
      demonstrate that a gold nanoparticle-modified quasi-2D nanomaterial would have 
      potential applications in the strategy design of the treatment of amyloid related 
      diseases in future.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Wang, Jie
AU  - Wang J
AD  - Institute for Advanced Materials, School of Material Science and Engineering, 
      Jiangsu University, Zhenjiang 212013, China. Electronic address: 
      wangjie@ujs.edu.cn.
FAU - Feng, Yonghai
AU  - Feng Y
AD  - Institute for Advanced Materials, School of Material Science and Engineering, 
      Jiangsu University, Zhenjiang 212013, China. Electronic address: 
      fengyonghai@ujs.edu.cn.
FAU - Tian, Xiaohua
AU  - Tian X
AD  - Institute for Advanced Materials, School of Material Science and Engineering, 
      Jiangsu University, Zhenjiang 212013, China.
FAU - Li, Chenglong
AU  - Li C
AD  - Institute for Advanced Materials, School of Material Science and Engineering, 
      Jiangsu University, Zhenjiang 212013, China.
FAU - Liu, Lei
AU  - Liu L
AD  - Institute for Advanced Materials, School of Material Science and Engineering, 
      Jiangsu University, Zhenjiang 212013, China. Electronic address: liul@ujs.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200419
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
SB  - IM
OTO - NOTNLM
OT  - Amyloid protein
OT  - Amyloid related disease
OT  - Disassembly
OT  - Inhibitors
OT  - Nanomaterials
COIS- Declaration of Competing Interest The authors declare no competing financial 
      interest.
EDAT- 2020/04/29 06:00
MHDA- 2020/04/29 06:01
CRDT- 2020/04/29 06:00
PHST- 2019/11/21 00:00 [received]
PHST- 2020/02/04 00:00 [revised]
PHST- 2020/04/12 00:00 [accepted]
PHST- 2020/04/29 06:01 [medline]
PHST- 2020/04/29 06:00 [pubmed]
PHST- 2020/04/29 06:00 [entrez]
AID - S0927-7765(20)30281-2 [pii]
AID - 10.1016/j.colsurfb.2020.111051 [doi]
PST - aheadofprint
SO  - Colloids Surf B Biointerfaces. 2020 Apr 19;192:111051. doi: 
      10.1016/j.colsurfb.2020.111051.