PMID- 32344535
OWN - NLM
STAT- MEDLINE
DCOM- 20210201
LR  - 20231103
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 8
DP  - 2020 Apr 24
TI  - Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes 
      Mellitus.
LID - 10.3390/ijms21083005 [doi]
LID - 3005
AB  - This review aims to summarize the knowledge about the relationship between 
      circadian rhythms and their influence on the development of type 2 diabetes 
      mellitus (T2DM) and metabolic syndrome. Circadian rhythms are controlled by 
      internal molecular feedback loops that synchronize the organism with the external 
      environment. These loops are affected by genetic and epigenetic factors. Genetic 
      factors include polymorphisms and mutations of circadian genes. The expression of 
      circadian genes is regulated by epigenetic mechanisms that change from prenatal 
      development to old age. Epigenetic modifications are influenced by the external 
      environment. Most of these modifications are affected by our own life style. 
      Irregular circadian rhythm and low quality of sleep have been shown to increase 
      the risk of developing T2DM and other metabolic disorders. Here, we attempt to 
      provide a wide description of mutual relationships between epigenetic regulation, 
      circadian rhythm, aging process and highlight new evidences that show possible 
      therapeutic advance in the field of chrono-medicine which will be more important 
      in the upcoming years.
FAU - Hudec, Michael
AU  - Hudec M
AD  - Department of Medical Genetics, Third Faculty of Medicine, Charles University; 
      Ruska 87, 100 00 Prague, Czech Republic.
FAU - Dankova, Pavlina
AU  - Dankova P
AD  - Department of Anthropology and Human Genetics, Faculty of Science, Charles 
      University; Vinicna 7, 128 00 Prague, Czech Republic.
FAU - Solc, Roman
AU  - Solc R
AUID- ORCID: 0000-0003-2322-6689
AD  - Department of Anthropology and Human Genetics, Faculty of Science, Charles 
      University; Vinicna 7, 128 00 Prague, Czech Republic.
FAU - Bettazova, Nardjas
AU  - Bettazova N
AD  - Department of Medical Genetics, Third Faculty of Medicine, Charles University; 
      Ruska 87, 100 00 Prague, Czech Republic.
FAU - Cerna, Marie
AU  - Cerna M
AUID- ORCID: 0000-0002-1208-5588
AD  - Department of Medical Genetics, Third Faculty of Medicine, Charles University; 
      Ruska 87, 100 00 Prague, Czech Republic.
LA  - eng
GR  - PROGRES Q36 and SVV/2020/the research programme of Charles University/
PT  - Journal Article
PT  - Review
DEP - 20200424
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Aging/genetics/metabolism
MH  - Animals
MH  - Biological Variation, Population
MH  - Circadian Clocks/genetics
MH  - Circadian Rhythm/*genetics
MH  - Diabetes Mellitus, Type 2/*etiology/metabolism
MH  - *Disease Susceptibility
MH  - Energy Metabolism
MH  - *Epigenesis, Genetic
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Metabolic Syndrome/etiology/metabolism
MH  - Sleep
PMC - PMC7215839
OTO - NOTNLM
OT  - aging
OT  - circadian clock
OT  - epigenetic regulation
OT  - metabolic syndrome
OT  - sleep
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2020/04/30 06:00
MHDA- 2021/02/02 06:00
PMCR- 2020/04/01
CRDT- 2020/04/30 06:00
PHST- 2020/01/24 00:00 [received]
PHST- 2020/04/14 00:00 [revised]
PHST- 2020/04/21 00:00 [accepted]
PHST- 2020/04/30 06:00 [entrez]
PHST- 2020/04/30 06:00 [pubmed]
PHST- 2021/02/02 06:00 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - ijms21083005 [pii]
AID - ijms-21-03005 [pii]
AID - 10.3390/ijms21083005 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Apr 24;21(8):3005. doi: 10.3390/ijms21083005.