PMID- 32344591
OWN - NLM
STAT- MEDLINE
DCOM- 20210119
LR  - 20210119
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 4
DP  - 2020 Apr 24
TI  - Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting 
      in Model Organisms.
LID - 10.3390/nu12041194 [doi]
LID - 1194
AB  - Genetic and pharmacological interventions have successfully extended healthspan 
      and lifespan in animals, but their genetic interventions are not appropriate 
      options for human applications and pharmacological intervention needs more solid 
      clinical evidence. Consequently, dietary manipulations are the only practical and 
      probable strategies to promote health and longevity in humans. Caloric 
      restriction (CR), reduction of calorie intake to a level that does not compromise 
      overall health, has been considered as being one of the most promising dietary 
      interventions to extend lifespan in humans. Although it is straightforward, 
      continuous reduction of calorie or food intake is not easy to practice in real 
      lives of humans. Recently, fasting-related interventions such as intermittent 
      fasting (IF) and time-restricted feeding (TRF) have emerged as alternatives of 
      CR. Here, we review the history of CR and fasting-related strategies in animal 
      models, discuss the molecular mechanisms underlying these interventions, and 
      propose future directions that can fill the missing gaps in the current 
      understanding of these dietary interventions. CR and fasting appear to extend 
      lifespan by both partially overlapping common mechanisms such as the target of 
      rapamycin (TOR) pathway and circadian clock, and distinct independent mechanisms 
      that remain to be discovered. We propose that a systems approach combining global 
      transcriptomic, metabolomic, and proteomic analyses followed by genetic 
      perturbation studies targeting multiple candidate pathways will allow us to 
      better understand how CR and fasting interact with each other to promote 
      longevity.
FAU - Hwangbo, Dae-Sung
AU  - Hwangbo DS
AD  - Department of Biology, University of Louisville, Louisville, KY 40292, USA.
FAU - Lee, Hye-Yeon
AU  - Lee HY
AD  - Department of Biological Sciences, Inha University, Incheon 22212, Korea.
FAU - Abozaid, Leen Suleiman
AU  - Abozaid LS
AD  - Department of Biology, University of Louisville, Louisville, KY 40292, USA.
FAU - Min, Kyung-Jin
AU  - Min KJ
AUID- ORCID: 0000-0001-5829-6842
AD  - Department of Biological Sciences, Inha University, Incheon 22212, Korea.
LA  - eng
GR  - 60570-01/Inha University/
PT  - Journal Article
PT  - Review
DEP - 20200424
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Biomarkers
MH  - *Caloric Restriction
MH  - Diet
MH  - Energy Intake
MH  - *Fasting
MH  - Humans
MH  - *Longevity
MH  - Models, Animal
MH  - Species Specificity
PMC - PMC7230387
OTO - NOTNLM
OT  - aging
OT  - calorie restriction
OT  - fasting
OT  - lifespan
OT  - longevity
COIS- The authors declare no conflict of interest.
EDAT- 2020/04/30 06:00
MHDA- 2021/01/20 06:00
PMCR- 2020/04/01
CRDT- 2020/04/30 06:00
PHST- 2020/03/31 00:00 [received]
PHST- 2020/04/19 00:00 [revised]
PHST- 2020/04/22 00:00 [accepted]
PHST- 2020/04/30 06:00 [entrez]
PHST- 2020/04/30 06:00 [pubmed]
PHST- 2021/01/20 06:00 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - nu12041194 [pii]
AID - nutrients-12-01194 [pii]
AID - 10.3390/nu12041194 [doi]
PST - epublish
SO  - Nutrients. 2020 Apr 24;12(4):1194. doi: 10.3390/nu12041194.