PMID- 32344690
OWN - NLM
STAT- MEDLINE
DCOM- 20210128
LR  - 20210128
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 25
IP  - 8
DP  - 2020 Apr 24
TI  - Combretum quadrangulare Extract Attenuates Atopic Dermatitis-Like Skin Lesions 
      through Modulation of MAPK Signaling in BALB/c Mice.
LID - 10.3390/molecules25082003 [doi]
LID - 2003
AB  - Atopic dermatitis (AD) is a chronic inflammatory disease. Combretum quadrangulare 
      (C. quadrangulare) is used as a traditional medicine to improve various 
      pathologies in Southeast Asia. In this study, we investigated the effects of C. 
      quadrangulare ethanol extract (CQ) on 1-chloro-2,4-dinitrobenzene (DNCB)-induced 
      AD like skin lesions in BALB/c mice. After administration with CQ (100, 200, and 
      400 mg/kg) for 6 weeks, AD symptoms, protein expression, immunoglobulin E (IgE), 
      thymus and activation-regulated chemokine (TARC), and ceramidase level were 
      measured in skin lesions of DNCB-induced BALB/c mice. CQ group improved the 
      dermatitis score, skin pH, transepidermal water loss (TEWL), and skin hydration. 
      Furthermore, histological analysis revealed that CQ attenuated the increased 
      epidermal thickness and infiltration of mast cells caused by DNCB. CQ also 
      increased the expression of filaggrin, and reduced the expression of ceramidase, 
      serum IgE level, and the number of eosinophils. CQ effectively inhibited 
      cytokines and chemokines such as interleukin (IL)-6, IL-13, TARC, and thymic 
      stromal lymphopoietin (TSLP) at the mRNA levels, as well as the activation of 
      mitogen-activated protein kinase (MAPK), including extracellular signal-regulated 
      kinase (ERK), c-jun N-terminal kinase (JNK), and p38 in the skin lesions. Taken 
      together, these findings demonstrate that CQ may be an effective treatment of 
      AD-like skin lesions by inhibiting the expression of inflammatory mediators via 
      the MAPK signaling pathways.
FAU - Park, Ju-Hyoung
AU  - Park JH
AD  - Department of Pharmacy, College of Pharmacy, Dankook University, Dandae-ro 119, 
      Dongnam, Cheonan, Chungnam 31116, Korea.
FAU - Hwang, Min Hee
AU  - Hwang MH
AD  - Bio-Center, Gyeonggido Business and Science Accelerator, Gwanggyo-ro 147, 
      Yeoungtong, Suwon, Gyeonggi 16229, Korea.
FAU - Cho, Young-Rak
AU  - Cho YR
AD  - Bio-Center, Gyeonggido Business and Science Accelerator, Gwanggyo-ro 147, 
      Yeoungtong, Suwon, Gyeonggi 16229, Korea.
FAU - Hong, Seong Su
AU  - Hong SS
AUID- ORCID: 0000-0002-2498-7546
AD  - Bio-Center, Gyeonggido Business and Science Accelerator, Gwanggyo-ro 147, 
      Yeoungtong, Suwon, Gyeonggi 16229, Korea.
FAU - Kang, Jae-Shin
AU  - Kang JS
AD  - Biological Genetic Resources Utilization Division, National Institute of 
      Biological Resources (NIBR), 42 Hwangyeong-ro, Seo-gu, Incheon 404-708, Korea.
FAU - Kim, Won Hee
AU  - Kim WH
AD  - Biological Genetic Resources Utilization Division, National Institute of 
      Biological Resources (NIBR), 42 Hwangyeong-ro, Seo-gu, Incheon 404-708, Korea.
FAU - Yang, Seung Hwan
AU  - Yang SH
AUID- ORCID: 0000-0003-0603-2209
AD  - Department of Biotechnology, Chonnam National University, Yeosu, Chonnam 59626, 
      Korea.
FAU - Seo, Dong-Wan
AU  - Seo DW
AD  - Department of Pharmacy, College of Pharmacy, Dankook University, Dandae-ro 119, 
      Dongnam, Cheonan, Chungnam 31116, Korea.
FAU - Oh, Joa Sub
AU  - Oh JS
AD  - Department of Pharmacy, College of Pharmacy, Dankook University, Dandae-ro 119, 
      Dongnam, Cheonan, Chungnam 31116, Korea.
FAU - Ahn, Eun-Kyung
AU  - Ahn EK
AD  - Bio-Center, Gyeonggido Business and Science Accelerator, Gwanggyo-ro 147, 
      Yeoungtong, Suwon, Gyeonggi 16229, Korea.
LA  - eng
GR  - NIBR 201804203/National Institute of Biological Resources/
PT  - Journal Article
DEP - 20200424
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - Combretum/*chemistry
MH  - Cytokines/metabolism
MH  - Dermatitis, Atopic/drug therapy/etiology/*metabolism/pathology
MH  - Disease Models, Animal
MH  - Immunohistochemistry
MH  - Inflammation Mediators/metabolism
MH  - MAP Kinase Signaling System/*drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Skin/*drug effects/*metabolism/pathology
PMC - PMC7221768
OTO - NOTNLM
OT  - Combretum quadrangulare
OT  - atopic dermatitis
OT  - inflammation
OT  - mitogen-activated protein kinase
OT  - skin lesions
COIS- The authors declare no conflict of interest.
EDAT- 2020/04/30 06:00
MHDA- 2021/01/29 06:00
PMCR- 2020/04/24
CRDT- 2020/04/30 06:00
PHST- 2020/03/20 00:00 [received]
PHST- 2020/04/16 00:00 [revised]
PHST- 2020/04/23 00:00 [accepted]
PHST- 2020/04/30 06:00 [entrez]
PHST- 2020/04/30 06:00 [pubmed]
PHST- 2021/01/29 06:00 [medline]
PHST- 2020/04/24 00:00 [pmc-release]
AID - molecules25082003 [pii]
AID - molecules-25-02003 [pii]
AID - 10.3390/molecules25082003 [doi]
PST - epublish
SO  - Molecules. 2020 Apr 24;25(8):2003. doi: 10.3390/molecules25082003.