PMID- 32346044
OWN - NLM
STAT- MEDLINE
DCOM- 20201125
LR  - 20240328
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Apr 28
TI  - Long-term potentiation prevents ketamine-induced aberrant neurophysiological 
      dynamics in the hippocampus-prefrontal cortex pathway in vivo.
PG  - 7167
LID - 10.1038/s41598-020-63979-5 [doi]
LID - 7167
AB  - N-methyl-D-aspartate receptor (NMDAr) antagonists such as ketamine (KET) produce 
      psychotic-like behavior in both humans and animal models. NMDAr hypofunction 
      affects normal oscillatory dynamics and synaptic plasticity in key brain regions 
      related to schizophrenia, particularly in the hippocampus and the prefrontal 
      cortex. It has been shown that prior long-term potentiation (LTP) occluded the 
      increase of synaptic efficacy in the hippocampus-prefrontal cortex pathway 
      induced by MK-801, a non-competitive NMDAr antagonist. However, it is not clear 
      whether LTP could also modulate aberrant oscillations and short-term plasticity 
      disruptions induced by NMDAr antagonists. Thus, we tested whether LTP could 
      mitigate the electrophysiological changes promoted by KET. We recorded HPC-PFC 
      local field potentials and evoked responses in urethane anesthetized rats, before 
      and after KET administration, preceded or not by LTP induction. Our results show 
      that KET promotes an aberrant delta-high-gamma cross-frequency coupling in the 
      PFC and an enhancement in HPC-PFC evoked responses. LTP induction prior to KET 
      attenuates changes in synaptic efficiency and prevents the increase in cortical 
      gamma amplitude comodulation. These findings are consistent with evidence that 
      increased efficiency of glutamatergic receptors attenuates cognitive impairment 
      in animal models of psychosis. Therefore, high-frequency stimulation in HPC may 
      be a useful tool to better understand how to prevent NMDAr hypofunction effects 
      on synaptic plasticity and oscillatory coordination in cortico-limbic circuits.
FAU - Lopes-Aguiar, Cleiton
AU  - Lopes-Aguiar C
AUID- ORCID: 0000-0001-9310-6338
AD  - Nucleo de Neurociencias, Department of Physiology and Biophysics, Institute of 
      Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, 
      31270-901, Brazil.
FAU - Ruggiero, Rafael N
AU  - Ruggiero RN
AUID- ORCID: 0000-0002-4712-6853
AD  - Department of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical 
      School, University of Sao Paulo, Ribeirao Preto, 14049-900, Brazil. 
      rafaruggiero@usp.br.
FAU - Rossignoli, Matheus T
AU  - Rossignoli MT
AUID- ORCID: 0000-0002-0522-2337
AD  - Department of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical 
      School, University of Sao Paulo, Ribeirao Preto, 14049-900, Brazil.
FAU - Esteves, Ingrid de Miranda
AU  - Esteves IM
AD  - Department of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical 
      School, University of Sao Paulo, Ribeirao Preto, 14049-900, Brazil.
FAU - Peixoto-Santos, Jose Eduardo
AU  - Peixoto-Santos JE
AUID- ORCID: 0000-0001-7461-1902
AD  - Department of Neurology and Neurosurgery, UNIFESP, Sao Paulo, SP, 04039-032, 
      Brazil.
FAU - Romcy-Pereira, Rodrigo N
AU  - Romcy-Pereira RN
AUID- ORCID: 0000-0003-1042-9196
AD  - Brain Institute, Federal University of Rio Grande do Norte, Natal, RN, 59056-450, 
      Brazil.
FAU - Leite, Joao P
AU  - Leite JP
AUID- ORCID: 0000-0003-0558-3519
AD  - Department of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical 
      School, University of Sao Paulo, Ribeirao Preto, 14049-900, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200428
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - Animals
MH  - *Cognitive Dysfunction/chemically induced/metabolism/physiopathology
MH  - Hippocampus/metabolism/*physiopathology
MH  - Ketamine/*adverse effects/pharmacology
MH  - Long-Term Potentiation/*drug effects
MH  - Male
MH  - Prefrontal Cortex/metabolism/*physiopathology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
PMC - PMC7188848
COIS- The authors declare no competing interests.
EDAT- 2020/04/30 06:00
MHDA- 2020/11/26 06:00
PMCR- 2020/04/28
CRDT- 2020/04/30 06:00
PHST- 2019/10/06 00:00 [received]
PHST- 2020/04/02 00:00 [accepted]
PHST- 2020/04/30 06:00 [entrez]
PHST- 2020/04/30 06:00 [pubmed]
PHST- 2020/11/26 06:00 [medline]
PHST- 2020/04/28 00:00 [pmc-release]
AID - 10.1038/s41598-020-63979-5 [pii]
AID - 63979 [pii]
AID - 10.1038/s41598-020-63979-5 [doi]
PST - epublish
SO  - Sci Rep. 2020 Apr 28;10(1):7167. doi: 10.1038/s41598-020-63979-5.