PMID- 32346187
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 0102-3616 (Print)
IS  - 1982-4378 (Electronic)
IS  - 0102-3616 (Linking)
VI  - 55
IP  - 2
DP  - 2020 Apr
TI  - Genetic Influence in Disc Degeneration - Systematic Review of Literature.
PG  - 131-138
LID - 10.1055/s-0039-1692626 [doi]
AB  - Disc degeneration is a condition that compromises the intervertebral disc 
      functions, which can lead to several important pathological processes, such as 
      disc herniation and canal stenosis. Although its etiology is still unknown, more 
      and more studies have demonstrated the preponderant role of genetic factors to 
      the detriment of environmental factors. Aiming to review the current knowledge 
      about the genes associated with intervertebral disc degeneration, we have 
      performed a narrative review based on the medical literature in the English 
      language from the last 10 years regarding this subject. We have concluded that 
      several genes have been associated with disc degeneration in humans, including 
      the genes for collagen I alpha-1 ( COL1A1 ), collagen IX ( COL9A2 and COL9A3 ), 
      collagen XI ( COL11A2 ), interleukin 6 ( IL-6 ), aggrecan ( AGC1 ), vitamin D 
      receptor ( VDR ), and matrix metalloproteinase 3 ( MMP-3) , in addition to 
      microRNAs. Therefore, the present review emphasizes the latest advancements in 
      the association of genes with specific phenotypes of degenerated discs, 
      single-nucleotide polymorphisms, heritage and genetic-environmental interactions 
      in relation to disc degeneration to help future reviews regarding the genetic 
      mechanisms underlying these processes.
FAU - Teles Filho, Ricardo Vieira
AU  - Teles Filho RV
AD  - Departamento de Ortopedia e Traumatologia, Faculdade de Medicina, Universidade 
      Federal de Goias, Goiania, GO, Brasil.
FAU - Abe, Guilherme de Matos
AU  - Abe GM
AD  - Departamento de Ortopedia e Traumatologia, Faculdade de Medicina, Universidade 
      Federal de Goias, Goiania, GO, Brasil.
FAU - Daher, Murilo Tavares
AU  - Daher MT
AUID- ORCID: 0000-0001-9589-5596
AD  - Departamento de Ortopedia e Traumatologia, Faculdade de Medicina, Universidade 
      Federal de Goias, Goiania, GO, Brasil.
AD  - Centro de Reabilitacao e Readaptacao Dr Henrique Santillo, Goiania, GO, Brasil.
LA  - eng
PT  - Journal Article
DEP - 20190827
PL  - Germany
TA  - Rev Bras Ortop (Sao Paulo)
JT  - Revista brasileira de ortopedia
JID - 0123326
PMC - PMC7186076
OTO - NOTNLM
OT  - genetics
OT  - intervertebral disc
OT  - intervertebral disc degeneration
OT  - polymorphism, genetic
COIS- Conflitos de Interesses Os autores declaram nao haver conflitos de interesses.
EDAT- 2020/04/30 06:00
MHDA- 2020/04/30 06:01
PMCR- 2020/04/01
CRDT- 2020/04/30 06:00
PHST- 2018/02/22 00:00 [received]
PHST- 2018/07/02 00:00 [accepted]
PHST- 2020/04/30 06:00 [entrez]
PHST- 2020/04/30 06:00 [pubmed]
PHST- 2020/04/30 06:01 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - 180108pt [pii]
AID - 10.1055/s-0039-1692626 [doi]
PST - ppublish
SO  - Rev Bras Ortop (Sao Paulo). 2020 Apr;55(2):131-138. doi: 10.1055/s-0039-1692626. 
      Epub 2019 Aug 27.