PMID- 32346796 OWN - NLM STAT- MEDLINE DCOM- 20200818 LR - 20200818 IS - 1433-7339 (Electronic) IS - 0941-4355 (Linking) VI - 28 IP - 9 DP - 2020 Sep TI - Progressive muscle relaxation is effective in preventing and alleviating of chemotherapy-induced nausea and vomiting among cancer patients: a systematic review of six randomized controlled trials. PG - 4051-4058 LID - 10.1007/s00520-020-05481-2 [doi] AB - PURPOSE: Previous systematic review suggested a beneficial effect of progressive muscle relaxation (PMR) for cancer patients receiving chemotherapy. However, poor quality of eligible studies which included in previous systematic review impaired the reliability and validity of findings. The aim of the present systematic review was to further assess the value of PMR in chemotherapy-induced nausea and vomiting. METHODS: We assigned two independent investigators to search potential studies in PubMed, Cochrane Controlled Register of Trial (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), China Biomedical Literature database (CBM), China National Knowledge Infrastructure (CNKI), and Wanfang Data database. We used data extraction sheet to extract essential information, and used the Cochrane risk of bias assessment tool to appraise the quality of eligible studies. Finally, we qualitatively summarized the results of all included studies. RESULTS: Six studies enrolling 288 patients were included finally. Of these 6 studies, three were labeled as moderate quality and the remaining studies were low quality. All included studies consistently suggested that PMR has a positive effect on chemotherapy-induced nausea and vomiting, especially on the incidence, frequency, and degree of delayed nausea and vomiting. CONCLUSION: Independent studies indicated that PMR was a beneficial approach of preventing and alleviating chemotherapy-induced nausea and vomiting among cancer patients. However, further studies enrolling other types of primary tumors should be designed in order to increase the generality of PMR because studies which were included in the present systematic review mainly considered patients with lung cancer and breast cancer. Moreover, future studies with high quality and large-scale are also warranted in order to address the limitations in the present systematic review such as poor quality and limited data of eligible studies. FAU - Tian, Xu AU - Tian X AD - Department of Gastroenterology, Chongqing University Cancer Hospital, Chongqing, 400030, China. FAU - Tang, Rong-Ying AU - Tang RY AD - Department of Nursing, Chongqing University Cancer Hospital, Chongqing, 400030, China. FAU - Xu, Ling-Li AU - Xu LL AD - Department of Nursing, Chongqing University Cancer Hospital, Chongqing, 400030, China. FAU - Xie, Wei AU - Xie W AD - Department of Nursing, First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, China. FAU - Chen, Hui AU - Chen H AD - Department of Gastroenterology, Chongqing University Cancer Hospital, Chongqing, 400030, China. FAU - Pi, Yuan-Ping AU - Pi YP AD - Department of Nursing, Chongqing University Cancer Hospital, Chongqing, 400030, China. FAU - Chen, Wei-Qing AU - Chen WQ AD - Department of Gastroenterology, Chongqing University Cancer Hospital, Chongqing, 400030, China. CQCH_ChenWQ@163.com. AD - Department of Gastroenterology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital & Chongqing Cancer Center, 181 Hanyu Road, Shapingba District, Chongqing, 400030, China. CQCH_ChenWQ@163.com. LA - eng GR - cstc2018jscx-msybX0030, cstc2018jcyjAX0737/Chongqing Science and Technology Commission (CN) Project/ PT - Journal Article PT - Systematic Review DEP - 20200428 PL - Germany TA - Support Care Cancer JT - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer JID - 9302957 SB - IM MH - Autogenic Training/*methods MH - Humans MH - Nausea/chemically induced/*therapy MH - Neoplasms/*complications/drug therapy MH - Randomized Controlled Trials as Topic MH - Reproducibility of Results MH - Vomiting/chemically induced/*therapy OTO - NOTNLM OT - Alternative and complementary medicine OT - Cancer OT - Chemotherapy-induced nausea and vomiting OT - Progressive muscle relaxation OT - Systematic review EDAT- 2020/04/30 06:00 MHDA- 2020/08/19 06:00 CRDT- 2020/04/30 06:00 PHST- 2020/01/22 00:00 [received] PHST- 2020/04/17 00:00 [accepted] PHST- 2020/04/30 06:00 [pubmed] PHST- 2020/08/19 06:00 [medline] PHST- 2020/04/30 06:00 [entrez] AID - 10.1007/s00520-020-05481-2 [pii] AID - 10.1007/s00520-020-05481-2 [doi] PST - ppublish SO - Support Care Cancer. 2020 Sep;28(9):4051-4058. doi: 10.1007/s00520-020-05481-2. Epub 2020 Apr 28.