PMID- 32346873
OWN - NLM
STAT- MEDLINE
DCOM- 20201216
LR  - 20210110
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 92
IP  - 10
DP  - 2020 Oct
TI  - Epidemiological and clinical features of asymptomatic patients with SARS-CoV-2 
      infection.
PG  - 1884-1889
LID - 10.1002/jmv.25944 [doi]
AB  - Few studies reported the severe acute respiratory syndrome coronavirus 2 
      (SARS-CoV-2) infected patients with completely asymptomatic throughout the 
      disease course. We investigated the epidemiological and clinical features of 
      patients infected by SARS-CoV-2 without any symptoms. Patients with confirmed 
      SARS-CoV-2 infection were retrospectively recruited. The demographic 
      characteristics, clinical data, treatment, and outcomes of SARS-CoV-2 infected 
      patients without any symptoms were analyzed. Fifteen (4.4%) of 342 SARS-CoV-2 
      infected patients did not develop any symptom during the course of the disease. 
      The median time from exposure to diagnosis was 7.0 days (interquartile range 
      [IQR]: 1.0-15.0 days). Of the 15 patients, 14 patients were diagnosed by tested 
      positive for SARS-CoV-2 in throat swabs, while one patient was only tested 
      positive for SARS-CoV-2 in anal swabs. During hospitalization, only 1 (6.7%) 
      patient developed lymphopenia. Abnormalities of chest computed tomography 
      examinations were detected in 8 (53.4%) patients on admission. As of 8 March 
      2020, all patients have been discharged. The median time of SARS-CoV-2 tested 
      negative from admission was 7.0 days (IQR: 4.0-9.0 days). Patients without any 
      symptoms but with SARS-CoV-2 exposure should be closely monitored and tested for 
      SARS-CoV-2 both in anal and throat swabs to excluded the infection. Asymptomatic 
      patients infected by SARS-CoV-2 have favorable outcomes.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Xu, Tianmin
AU  - Xu T
AD  - Department of Infectious Diseases, The Third People's Hospital of Changzhou, 
      Changzhou, China.
FAU - Huang, Rui
AU  - Huang R
AD  - Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated 
      Hospital of Nanjing University Medical School, Nanjing, China.
FAU - Zhu, Li
AU  - Zhu L
AD  - Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital of 
      Soochow University, Suzhou, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated 
      Hospital of Nanjing University Medical School, Nanjing, China.
FAU - Cheng, Juan
AU  - Cheng J
AD  - Department of Infectious Diseases, Yancheng Second People's Hospital, Yancheng, 
      China.
FAU - Zhang, Biao
AU  - Zhang B
AD  - Department of Quality Control Office, Huai'an No. 4 People's Hospital, Huai'an, 
      China.
FAU - Zhao, Haiyan
AU  - Zhao H
AD  - Department of Infectious Diseases, Suqian People's Hospital of Nanjing Drum Tower 
      Hospital Group, Suqian, China.
FAU - Chen, Kang
AU  - Chen K
AD  - Department of Tuberculosis, The Third People's Hospital of Changzhou, Changzhou, 
      China.
FAU - Shao, Huaping
AU  - Shao H
AD  - Department of Infectious Diseases, Suqian People's Hospital of Nanjing Drum Tower 
      Hospital Group, Suqian, China.
FAU - Zhu, Chuanwu
AU  - Zhu C
AD  - Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital of 
      Soochow University, Suzhou, China.
FAU - Wu, Chao
AU  - Wu C
AUID- ORCID: 0000-0002-1657-010X
AD  - Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated 
      Hospital of Nanjing University Medical School, Nanjing, China.
FAU - Liu, Longgen
AU  - Liu L
AD  - Department of Infectious Diseases, The Third People's Hospital of Changzhou, 
      Changzhou, China.
LA  - eng
GR  - 14380459/Fundamental Research Funds for the Central Universities/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200512
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Asymptomatic Infections
MH  - COVID-19/diagnosis/*epidemiology/*physiopathology
MH  - Child
MH  - China
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Young Adult
PMC - PMC7267538
OTO - NOTNLM
OT  - asymptomatic
OT  - coronavirus disease 2019
OT  - severe acute respiratory syndrome coronavirus 2
COIS- The authors declare that there are no conflict of interests.
EDAT- 2020/04/30 06:00
MHDA- 2020/12/17 06:00
PMCR- 2020/05/12
CRDT- 2020/04/30 06:00
PHST- 2020/03/28 00:00 [received]
PHST- 2020/04/12 00:00 [accepted]
PHST- 2020/04/30 06:00 [pubmed]
PHST- 2020/12/17 06:00 [medline]
PHST- 2020/04/30 06:00 [entrez]
PHST- 2020/05/12 00:00 [pmc-release]
AID - JMV25944 [pii]
AID - 10.1002/jmv.25944 [doi]
PST - ppublish
SO  - J Med Virol. 2020 Oct;92(10):1884-1889. doi: 10.1002/jmv.25944. Epub 2020 May 12.