PMID- 32347563
OWN - NLM
STAT- MEDLINE
DCOM- 20210329
LR  - 20210329
IS  - 1939-165X (Electronic)
IS  - 0275-6382 (Linking)
VI  - 49
IP  - 2
DP  - 2020 Jun
TI  - Lymphocytosis and lymphadenopathy in a dog arising from two distinct lymphoid 
      neoplasms.
PG  - 307-311
LID - 10.1111/vcp.12855 [doi]
AB  - A 10-year-old intact male Golden Retriever was presented to The Ohio State 
      University Veterinary Medical Center for acute, non-painful facial swelling of 
      the right mandibular region. On physical examination, the right mandibular 
      swelling was found to represent marked lymphadenopathy of the submandibular lymph 
      node. At this time, marked lymphadenopathy of the prescapular and popliteal lymph 
      nodes was also appreciated. The CBC showed a moderate leukocytosis (38.4 x 10(9) 
      cells/L, reference interval [RI] 4.8-13.9 x 10(9) cells/L) characterized by a 
      moderate lymphocytosis (28.4 x 10(9) cells/L, RI 1.0-4.6 x 10(9) cells/L). 
      Evaluation of peripheral blood and enlarged prescapular and popliteal lymph nodes 
      revealed two morphologically different populations of homogeneous lymphocytes, 
      with the lymphocyte population in the lymph nodes being distinct from that in the 
      blood smear. Flow cytometry of peripheral blood revealed CD45-, CD5+, CD4-, CD8-, 
      variably CD21+ neoplastic lymphocytes compatible with T-zone lymphocytes due to 
      the absence of CD45 expression. Flow cytometry of the lymph node aspirate 
      indicated a distinct population of CD21+ lymphocytes consistent with a B-cell 
      phenotype along with a smaller proportion of the T-zone lymphocytes observed in 
      the blood confirming the presence of two distinct populations of neoplastic 
      lymphocytes, one involving T cells, and the other involving B cells.
CI  - (c) 2020 American Society for Veterinary Clinical Pathology.
FAU - Long, Mackenzie E
AU  - Long ME
AUID- ORCID: 0000-0001-6387-4440
AD  - Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, 
      USA.
FAU - Evans, Brittany
AU  - Evans B
AD  - Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, 
      OH, USA.
FAU - Avery, Anne C
AU  - Avery AC
AD  - Department of Veterinary Medicine and Biomedical Sciences, Colorado State 
      University, Fort Collins, CO, USA.
FAU - Wellman, Maxey L
AU  - Wellman ML
AD  - Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, 
      USA.
LA  - eng
PT  - Case Reports
DEP - 20200429
PL  - United States
TA  - Vet Clin Pathol
JT  - Veterinary clinical pathology
JID - 9880575
SB  - IM
MH  - Animals
MH  - Dog Diseases/*diagnosis/pathology
MH  - Dogs
MH  - Flow Cytometry/veterinary
MH  - Lymph Nodes/pathology
MH  - Lymphadenopathy/diagnosis/pathology/*veterinary
MH  - Lymphocyte Subsets/pathology
MH  - Lymphocytes/pathology
MH  - Lymphocytosis/diagnosis/pathology/*veterinary
MH  - Lymphoma/diagnosis/pathology/*veterinary
MH  - Male
MH  - T-Lymphocytes/pathology
OTO - NOTNLM
OT  - B-cell lymphoma
OT  - T-zone lymphoma
OT  - canine lymphoma
OT  - cytology
OT  - flow cytometry
EDAT- 2020/04/30 06:00
MHDA- 2021/03/30 06:00
CRDT- 2020/04/30 06:00
PHST- 2019/04/15 00:00 [received]
PHST- 2019/09/05 00:00 [revised]
PHST- 2019/09/23 00:00 [accepted]
PHST- 2020/04/30 06:00 [pubmed]
PHST- 2021/03/30 06:00 [medline]
PHST- 2020/04/30 06:00 [entrez]
AID - 10.1111/vcp.12855 [doi]
PST - ppublish
SO  - Vet Clin Pathol. 2020 Jun;49(2):307-311. doi: 10.1111/vcp.12855. Epub 2020 Apr 
      29.