PMID- 32347967
OWN - NLM
STAT- MEDLINE
DCOM- 20211117
LR  - 20211117
IS  - 1440-1681 (Electronic)
IS  - 0305-1870 (Linking)
VI  - 47
IP  - 9
DP  - 2020 Sep
TI  - Hyperbaric oxygen treatment mitigates liver damage in mice with noise exposure.
PG  - 1564-1574
LID - 10.1111/1440-1681.13330 [doi]
AB  - Noise exposure relates to various pathological disorders including liver damage, 
      preventive measures of which are being demanded. Hyperbaric oxygen treatment 
      (HBOT), as a non-invasive procedure, exerts convincing therapeutic potency on 
      multiple liver diseases. The efficacy of HBOT in mitigating noise induced liver 
      damage (NILD) and associated mechanisms would be elucidated here. Mice were 
      subject to broad band noise (20-20k Hz, 90-110 dB) for 5 days by 3 hours/day. 
      HBOT with 2.5 atmosphere absolute (ata) was employed before noise exposure. 
      Morphology of liver tissue was examined by hematoxylin-eosin (HE) staining. Oil 
      Red O (ORO), transferase-mediated dUTP nick end labelling (TUNEL) test and 
      western blot were utilized to detect lipid accumulation, apoptotic cells and 
      protein expression, respectively. Ceramide (Cer) level was assayed by 
      immunohistochemistry (IHC) analysis. With noise exposure, conspicuous structural 
      derangement and lipid deposition occurred in liver tissue of mice, which was 
      alleviated significantly by the application of HBOT. Meanwhile, HBOT reduced the 
      proportion of apoptotic hepatocytes, restraining the superoxide production in 
      noise exposed mice. In view of underlying mechanisms, noise enhanced the acid 
      sphingomyelinase (ASM) protein expression and the Cer generation in liver tissue 
      of mice which was reversed substantially by HBOT. Altogether, HBOT ameliorates 
      the structural and functional derangement of liver by neutralizing the ASM/Cer 
      pathway in noise exposed mice.
CI  - (c) 2020 John Wiley & Sons Australia, Ltd.
FAU - Meng, Xingxing
AU  - Meng X
AUID- ORCID: 0000-0003-4828-9555
AD  - Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an, 
      China.
FAU - Zhang, Xi
AU  - Zhang X
AD  - Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an, 
      China.
FAU - Su, Yuting
AU  - Su Y
AD  - Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an, 
      China.
FAU - Gu, Zhenghui
AU  - Gu Z
AD  - Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an, 
      China.
FAU - Xie, Xiaoping
AU  - Xie X
AD  - Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an, 
      China.
FAU - Chang, Yaoming
AU  - Chang Y
AD  - Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an, 
      China.
FAU - Bao, Junxiang
AU  - Bao J
AUID- ORCID: 0000-0001-5805-0543
AD  - Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200518
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 0 (Ceramides)
RN  - 11062-77-4 (Superoxides)
RN  - EC 3.1.4.12 (ASMase, mouse)
RN  - EC 3.1.4.12 (Sphingomyelin Phosphodiesterase)
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - Ceramides/metabolism
MH  - Disease Models, Animal
MH  - *Hyperbaric Oxygenation
MH  - Lipid Droplets/metabolism/pathology
MH  - Liver/metabolism/*pathology
MH  - Liver Diseases/etiology/metabolism/pathology/*prevention & control
MH  - Male
MH  - Mice
MH  - Mitochondria, Liver/metabolism/pathology
MH  - *Noise
MH  - Oxidative Stress
MH  - Signal Transduction
MH  - Sphingomyelin Phosphodiesterase/metabolism
MH  - Superoxides/metabolism
OTO - NOTNLM
OT  - acid sphingomyelinase
OT  - ceramide
OT  - hyperbaric oxygen
OT  - liver
OT  - noise
EDAT- 2020/04/30 06:00
MHDA- 2021/11/18 06:00
CRDT- 2020/04/30 06:00
PHST- 2020/01/11 00:00 [received]
PHST- 2020/04/08 00:00 [revised]
PHST- 2020/04/23 00:00 [accepted]
PHST- 2020/04/30 06:00 [pubmed]
PHST- 2021/11/18 06:00 [medline]
PHST- 2020/04/30 06:00 [entrez]
AID - 10.1111/1440-1681.13330 [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 2020 Sep;47(9):1564-1574. doi: 
      10.1111/1440-1681.13330. Epub 2020 May 18.