PMID- 32349707
OWN - NLM
STAT- MEDLINE
DCOM- 20210319
LR  - 20210319
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Apr 29
TI  - Clinical implications of pachyvessels in polypoidal choroidal vasculopathy.
PG  - 170
LID - 10.1186/s12886-020-01443-8 [doi]
LID - 170
AB  - BACKGROUND: Polypoidal choroidal vasculopathy (PCV) is one of the disorders 
      within the pachychoroid spectrum diseases. The presence of pachyvessels is one of 
      the characteristics of pachychoroid disorders. However, the relationship between 
      the presence of pachyvessels and the clinical characteristics of PCV eyes has not 
      been determined. The purpose of this study was to determine the relationship 
      between the presence of choroidal pachyvessels and the clinical characteristics 
      of eyes with PCV. METHODS: The medical records of patients who were diagnosed 
      with PCV and were treatment-naive were reviewed. Fluorescein and indocyanine 
      green angiography, fundus photography, spectral domain optical coherence 
      tomography (SD-OCT), and enhanced depth imaging OCT (EDI-OCT) were used to obtain 
      images of the choroid. The presence of pathologically dilated outer choroidal 
      vessels, pachyvessels, was determined by ICGA images. These pachyvessels were 
      confirmed to correspond with the large choroidal vessels in the EDI OCT images. 
      The PCV eyes were divided into two groups based on the presence or absence of 
      pachyvessels and clinical features and subfoveal choroidal thickness (SFCT) were 
      evaluated between the two groups. RESULTS: Eighty-six eyes of 84 patients with 
      PCV were evaluated. Pachyvessels were detected in 48 eyes (55.8%). The mean SFCT 
      was 203.9 +/- 83.9 mum in all 86 eyes, and it was significantly thinner in eyes with 
      pachyvessels (+) than without pachyvessels (-) (183.2 +/- 58.4 mum vs 
      230.2 +/- 103.1 mum; P = 0.01). The differences in the incidence of subretinal 
      fluid, pigment epithelial detachments, and hemorrhages between the two groups 
      were not significant. However, the PCV eyes in pachyvessels (+) group with 
      hemorrhage had the thinnest choroid (P = 0.047). The choroidal features of the 
      fellow eyes were similar to those of the PCV affected eyes, that is, the fellow 
      eyes in pachyvessels (+) group had pachyvessels and the fellow eyes in 
      pachyvessels (-) group did not have pachyvessels. CONCLUSIONS: Pachyvessels were 
      presented 55.8% in eyes with PCV, and these eyes had the thin SFCT. The presence 
      of pachyvessels and attenuation of the inner choroid were probably due to the 
      pathological changes in the eyes with PCV.
FAU - Ijuin, Nobuo
AU  - Ijuin N
AD  - Department of Ophthalmology, Nara City Hospital, Nara, Japan.
FAU - Tsujinaka, Hiroki
AU  - Tsujinaka H
AD  - Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara, 
      Nara, 634-8522, Japan.
FAU - Hirai, Hiromasa
AU  - Hirai H
AD  - Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara, 
      Nara, 634-8522, Japan.
FAU - Jimura, Hironobu
AU  - Jimura H
AD  - Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara, 
      Nara, 634-8522, Japan.
FAU - Nakao, Shigeya
AU  - Nakao S
AD  - Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara, 
      Nara, 634-8522, Japan.
FAU - Yamashita, Mariko
AU  - Yamashita M
AD  - Department of Ophthalmology, Nara City Hospital, Nara, Japan.
FAU - Nishi, Tomo
AU  - Nishi T
AD  - Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara, 
      Nara, 634-8522, Japan.
FAU - Ueda, Tetsuo
AU  - Ueda T
AD  - Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara, 
      Nara, 634-8522, Japan.
FAU - Ogata, Nahoko
AU  - Ogata N
AD  - Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara, 
      Nara, 634-8522, Japan. ogata@naramed-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20200429
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroid/*blood supply
MH  - Choroidal Neovascularization/*diagnosis/physiopathology
MH  - Coloring Agents/administration & dosage
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Indocyanine Green/administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Polyps/*diagnosis/physiopathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Acuity
PMC - PMC7191784
OTO - NOTNLM
OT  - Pachychoroid
OT  - Pachyvessels
OT  - Polypoidal choroidal vasculopathy
COIS- The authors declare that they have no competing interests.
EDAT- 2020/05/01 06:00
MHDA- 2021/03/20 06:00
PMCR- 2020/04/29
CRDT- 2020/05/01 06:00
PHST- 2019/10/04 00:00 [received]
PHST- 2020/04/22 00:00 [accepted]
PHST- 2020/05/01 06:00 [entrez]
PHST- 2020/05/01 06:00 [pubmed]
PHST- 2021/03/20 06:00 [medline]
PHST- 2020/04/29 00:00 [pmc-release]
AID - 10.1186/s12886-020-01443-8 [pii]
AID - 1443 [pii]
AID - 10.1186/s12886-020-01443-8 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2020 Apr 29;20(1):170. doi: 10.1186/s12886-020-01443-8.