PMID- 32350175
OWN - NLM
STAT- MEDLINE
DCOM- 20210210
LR  - 20210210
IS  - 1881-7742 (Electronic)
IS  - 0301-4800 (Linking)
VI  - 66
IP  - 2
DP  - 2020
TI  - Liver-Oriented Acute Metabolic Effects of A Low Dose of L-Carnitine under 
      Fat-Mobilizing Conditions: Pilot Human Clinical Trial.
PG  - 136-149
LID - 10.3177/jnsv.66.136 [doi]
AB  - The acute metabolic effect of low dosages of L-carnitine under fat-mobilizing 
      conditions was investigated. Healthy subjects (Study 1: n=5; Study 2: n=6) were 
      asked to fast overnight. Then, 30 min of aerobic exercise on a cycle ergometer 
      was performed after supplementation, followed by a 3.5-h sedentary recovery 
      phase. The following ingestion patterns were used: Study 1 (i) noningestion, (ii) 
      750 mg of L-carnitine (LC), and (iii) 750 mg of LC+50 g of carbohydrate (CHO); 
      Study 2 (iv) noningestion, (v) 500 mg of LC, (vi) 30 mg of CoQ(10), and (vii) 500 
      mg of LC+30 mg of CoQ(10). The energy expenditure (EE) and nonprotein respiratory 
      quotient (npRQ) were measured during the pre-exercise, postexercise, and recovery 
      periods. Serum free carnitine, acetylcarnitine, total carnitine (Study 1 and 2), 
      and ketone bodies (Study 2) were measured. The 750 mg LC treatment significantly 
      facilitated fat oxidation during the recovery phases (p<0.05) without elevating 
      EE. The higher fat oxidation associated with LC was completely suppressed by CHO. 
      CoQ(10) affected neither npRQ nor EE. npRQ was significantly correlated with the 
      serum total ketone bodies (R=-0.68, p<0.001) and acetylcarnitine (R=-0.61--0.70, 
      p<0.001). The highest correlation was found between acetylcarnitine and total 
      ketone bodies immediately after exercise (R=0.85, p<0.001). In conclusion, LC 
      enhanced liver fat utilization and ketogenesis in an acute manner without 
      stimulating EE under fat-mobilizing conditions.
FAU - Odo, Satoshi
AU  - Odo S
AD  - Department of Biotechnology and Life Science, Tokyo University of Agriculture and 
      Technology.
AD  - Lonza Japan Ltd.
FAU - Tanabe, Koji
AU  - Tanabe K
AD  - Lonza Japan Ltd.
FAU - Yohda, Masafumi
AU  - Yohda M
AD  - Department of Biotechnology and Life Science, Tokyo University of Agriculture and 
      Technology.
FAU - Yamauchi, Masamitsu
AU  - Yamauchi M
AD  - Department of Management Nutrition, Aichi Gakusen University.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Japan
TA  - J Nutr Sci Vitaminol (Tokyo)
JT  - Journal of nutritional science and vitaminology
JID - 0402640
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Ketone Bodies)
RN  - 1339-63-5 (Ubiquinone)
RN  - 6DH1W9VH8Q (Acetylcarnitine)
RN  - EJ27X76M46 (coenzyme Q10)
RN  - S7UI8SM58A (Carnitine)
SB  - IM
MH  - Acetylcarnitine/blood
MH  - Adipose Tissue/metabolism
MH  - Adult
MH  - Bicycling
MH  - Carnitine/administration & dosage/blood/*pharmacology
MH  - Dietary Carbohydrates
MH  - Double-Blind Method
MH  - *Energy Metabolism
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Ketone Bodies/*blood
MH  - Lipolysis/*drug effects
MH  - Liver/*drug effects/metabolism
MH  - Male
MH  - Muscle, Skeletal/metabolism
MH  - Oxidation-Reduction
MH  - Pilot Projects
MH  - Respiration
MH  - Ubiquinone/analogs & derivatives/pharmacology
MH  - Young Adult
OTO - NOTNLM
OT  - L-carnitine
OT  - acetylcarnitine
OT  - acute effect
OT  - fat mobilization
OT  - healthy subjects
OT  - ketogenesis
OT  - ketone bodies
OT  - beta-oxidation
EDAT- 2020/05/01 06:00
MHDA- 2021/02/11 06:00
CRDT- 2020/05/01 06:00
PHST- 2020/05/01 06:00 [entrez]
PHST- 2020/05/01 06:00 [pubmed]
PHST- 2021/02/11 06:00 [medline]
AID - 10.3177/jnsv.66.136 [doi]
PST - ppublish
SO  - J Nutr Sci Vitaminol (Tokyo). 2020;66(2):136-149. doi: 10.3177/jnsv.66.136.