PMID- 32350903
OWN - NLM
STAT- MEDLINE
DCOM- 20210128
LR  - 20210128
IS  - 1600-051X (Electronic)
IS  - 0303-6979 (Linking)
VI  - 47
IP  - 6
DP  - 2020 Jun
TI  - A randomized controlled trial of the effects of non-surgical periodontal therapy 
      on cardiac function assessed by echocardiography in type 2 diabetic patients.
PG  - 726-736
LID - 10.1111/jcpe.13291 [doi]
AB  - BACKGROUND: Periodontitis significantly increases the risk of diabetic 
      complications. This clinical trial investigated the effects of periodontal 
      therapy on cardiac function in patients with type 2 diabetes mellitus (T2DM) and 
      periodontitis. MATERIALS AND METHODS: Fifty-eight subjects with T2DM and 
      periodontitis were randomly allocated to Treatment Group (n = 29) receiving 
      non-surgical periodontal therapy, and Control Group (n = 29) having only oral 
      hygiene instructions with delayed periodontal treatment until completion of this 
      6-month study. The left ventricle (LV) diastolic function was assessed by 
      echocardiography with the tissue Doppler imaging index (E/e' ratio); and LV 
      hypertrophy was evaluated by LV mass index (LVMI). Blood samples were collected 
      for biochemical analysis. RESULTS: The intention-to-treat analysis showed that 
      periodontal treatment significantly reduced the E/e' ratio by 1.66 (95% CI: -2.64 
      to -0.68, p < .01), along with marked improvement of periodontal conditions 
      (p < .05). LVMI was not altered at the 6-month follow-up. The serum levels of 
      N-terminal pro-B type natriuretic peptide (NT-proBNP) as a cardiac stress 
      biomarker, C-reactive protein and interleukin-6 decreased numerically without 
      reaching statistical significance. CONCLUSION: The present study provides the 
      first evidence that non-surgical periodontal therapy may improve cardiac 
      diastolic function in type 2 diabetic patients with periodontitis.
CI  - (c) 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Wang, Yi
AU  - Wang Y
AUID- ORCID: 0000-0002-8391-1453
AD  - Division of Periodontology & Implant Dentistry, Faculty of Dentistry, The 
      University of Hong Kong, Hong Kong SAR, China.
AD  - School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
FAU - Liu, Hin Nam
AU  - Liu HN
AD  - Division of Periodontology & Implant Dentistry, Faculty of Dentistry, The 
      University of Hong Kong, Hong Kong SAR, China.
FAU - Zhen, Zhe
AU  - Zhen Z
AD  - Division of Cardiology, Department of Medicine, Li Ka Shing Faculty of Medicine, 
      The University of Hong Kong, Hong Kong SAR, China.
FAU - Pelekos, George
AU  - Pelekos G
AUID- ORCID: 0000-0003-1917-1988
AD  - Division of Periodontology & Implant Dentistry, Faculty of Dentistry, The 
      University of Hong Kong, Hong Kong SAR, China.
FAU - Wu, Mei Zhen
AU  - Wu MZ
AD  - Division of Cardiology, Department of Medicine, Li Ka Shing Faculty of Medicine, 
      The University of Hong Kong, Hong Kong SAR, China.
FAU - Chen, Yan
AU  - Chen Y
AD  - Division of Cardiology, Department of Medicine, Li Ka Shing Faculty of Medicine, 
      The University of Hong Kong, Hong Kong SAR, China.
FAU - Tonetti, Maurizio
AU  - Tonetti M
AD  - Division of Periodontology & Implant Dentistry, Faculty of Dentistry, The 
      University of Hong Kong, Hong Kong SAR, China.
FAU - Tse, Hung Fat
AU  - Tse HF
AD  - Division of Cardiology, Department of Medicine, Li Ka Shing Faculty of Medicine, 
      The University of Hong Kong, Hong Kong SAR, China.
FAU - Yiu, Kai Hang
AU  - Yiu KH
AD  - Division of Cardiology, Department of Medicine, Li Ka Shing Faculty of Medicine, 
      The University of Hong Kong, Hong Kong SAR, China.
FAU - Jin, Lijian
AU  - Jin L
AUID- ORCID: 0000-0002-5340-9710
AD  - Division of Periodontology & Implant Dentistry, Faculty of Dentistry, The 
      University of Hong Kong, Hong Kong SAR, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20200429
PL  - United States
TA  - J Clin Periodontol
JT  - Journal of clinical periodontology
JID - 0425123
RN  - 0 (Peptide Fragments)
SB  - IM
MH  - *Diabetes Complications
MH  - *Diabetes Mellitus, Type 2/complications/therapy
MH  - Echocardiography
MH  - Humans
MH  - Peptide Fragments
MH  - *Periodontitis
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - cardiac function
OT  - diabetes mellitus
OT  - echocardiography
OT  - periodontitis
OT  - randomized clinical trial
EDAT- 2020/05/01 06:00
MHDA- 2021/01/29 06:00
CRDT- 2020/05/01 06:00
PHST- 2019/11/14 00:00 [received]
PHST- 2020/02/24 00:00 [revised]
PHST- 2020/04/03 00:00 [accepted]
PHST- 2020/05/01 06:00 [pubmed]
PHST- 2021/01/29 06:00 [medline]
PHST- 2020/05/01 06:00 [entrez]
AID - 10.1111/jcpe.13291 [doi]
PST - ppublish
SO  - J Clin Periodontol. 2020 Jun;47(6):726-736. doi: 10.1111/jcpe.13291. Epub 2020 
      Apr 29.