PMID- 32352004
OWN - NLM
STAT- MEDLINE
DCOM- 20210210
LR  - 20240329
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2020
DP  - 2020
TI  - The Role of Cavin3 in the Progression of Lung Cancer and Its Mechanism.
PG  - 6364801
LID - 10.1155/2020/6364801 [doi]
LID - 6364801
AB  - OBJECTIVE: The purpose of this study was to describe the role of Cavin3 in the 
      progression of lung cancer and its underlying mechanism. METHODS: Totally, 200 
      cases of lung cancer tissues and corresponding paracancer tissues were collected. 
      Cavin3 expression in samples was determined by qRT-PCR, and the correlation with 
      lung cancer stages as well as prognosis was statistically analyzed combined with 
      matched clinical information. To investigate the mechanism of Cavin3 in lung 
      cancer progression, firstly, Cavin3 was detected in lung cancer cell lines A549, 
      PC9, and H520. Then, cells with stable Cavin3 overexpression and Cavin3 knockout 
      were established to determine the effect of Cavin3 overexpression on the 
      mammalian target of rapamycin (mTOR) signaling pathway. Subsequently, cells were 
      harvested for cell proliferation, migration, and invasion assays in vitro, as 
      well as nude mouse transplantation tumor experiment in vivo. RESULTS: Cavin3 was 
      seen to be highly expressed in cancer tissues. Statistical analysis with matched 
      clinical data showed that Cavin3 as a prognostic indicator of lung cancer had 
      important clinical value. In addition, it could be found that high expression of 
      Cavin3 was able to promote cell proliferation, migration, and invasion and also 
      potentiate tumor formation in vivo. CONCLUSION: Cavin3 was highly expressed in 
      lung cancer, and it was capable to promote cell proliferation, invasion, and 
      migration.
CI  - Copyright (c) 2020 Gaozhong Sun and Kewei Ni.
FAU - Sun, Gaozhong
AU  - Sun G
AUID- ORCID: 0000-0003-3309-6013
AD  - Department of Cardio-Thoracic Surgery, Zhejiang Provincial People's Hospital, 
      People's Hospital of Hangzhou Medical College, 158 Shangtang Road, Hangzhou, 
      310014 Zhejiang, China.
FAU - Ni, Kewei
AU  - Ni K
AUID- ORCID: 0000-0003-1707-6979
AD  - Department of Cardio-Thoracic Surgery, Zhejiang Provincial People's Hospital, 
      People's Hospital of Hangzhou Medical College, 158 Shangtang Road, Hangzhou, 
      310014 Zhejiang, China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20200414
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (CAVIN3 protein, human)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Neoplasm Proteins)
SB  - IM
RIN - Biomed Res Int. 2024 Mar 20;2024:9815768. PMID: 38550175
MH  - A549 Cells
MH  - Animals
MH  - *Cell Movement
MH  - *Cell Proliferation
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - *Intracellular Signaling Peptides and Proteins/genetics/metabolism
MH  - *Lung Neoplasms/genetics/metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mice, Nude
MH  - Neoplasm Invasiveness
MH  - *Neoplasm Proteins/genetics/metabolism
MH  - Retrospective Studies
PMC - PMC7178469
COIS- The authors have no conflicts of interest to declare.
EDAT- 2020/05/01 06:00
MHDA- 2021/02/11 06:00
PMCR- 2020/04/14
CRDT- 2020/05/01 06:00
PHST- 2020/02/17 00:00 [received]
PHST- 2020/03/11 00:00 [revised]
PHST- 2020/03/16 00:00 [accepted]
PHST- 2020/05/01 06:00 [entrez]
PHST- 2020/05/01 06:00 [pubmed]
PHST- 2021/02/11 06:00 [medline]
PHST- 2020/04/14 00:00 [pmc-release]
AID - 10.1155/2020/6364801 [doi]
PST - epublish
SO  - Biomed Res Int. 2020 Apr 14;2020:6364801. doi: 10.1155/2020/6364801. eCollection 
      2020.