PMID- 32352164
OWN - NLM
STAT- MEDLINE
DCOM- 20210301
LR  - 20210301
IS  - 1365-2168 (Electronic)
IS  - 0007-1323 (Print)
IS  - 0007-1323 (Linking)
VI  - 107
IP  - 11
DP  - 2020 Oct
TI  - Surgery for multiple endocrine neoplasia type 1-related insulinoma: long-term 
      outcomes in a large international cohort.
PG  - 1489-1499
LID - 10.1002/bjs.11632 [doi]
AB  - BACKGROUND: Insulinomas are found in 10-15 per cent of patients with multiple 
      endocrine neoplasia type 1 (MEN1) and lead to life-threatening hypoglycaemia. 
      Surgical outcome and the optimal surgical strategy for MEN1-related insulinoma 
      are unknown. METHODS: Patients with MEN1-related insulinomas were identified in 
      46 centres in Europe and North America between 1990 and 2016. Insulinomas were 
      considered localized if the lesion was in the pancreatic head or body/tail. 
      Patients with pancreatic neuroendocrine tumours throughout the pancreas were 
      suspected of having multifocal insulinoma. The primary outcome was postoperative 
      hypoglycaemia, defined as persistent hypoglycaemia, or recurrent hypoglycaemia 
      caused by a new insulinoma or insulin-producing liver metastases. 
      Hypoglycaemia-free survival was estimated by the Kaplan-Meier method. RESULTS: 
      Ninety-six patients underwent resection for MEN1-related insulinoma. Sixty-three 
      and 33 patients had localized and multifocal insulinomas respectively. After a 
      median follow-up of 8 (range 1-22) years, one patient (1 per cent) had persistent 
      disease and six (6 per cent) had developed recurrent disease, of whom four had a 
      new insulinoma. The 10-year hypoglycaemia-free survival rate was 91 (95 per cent 
      c.i. 80 to 96) per cent. Of those with localized disease, 46 patients underwent 
      pancreatic resection and 17 enucleation. One of these patients had persistent 
      disease and one developed recurrent insulinoma. Among patients with multifocal 
      disease, three developed new insulinomas and two developed insulin-producing 
      liver metastases. CONCLUSION: Surgery for MEN1-related insulinoma is more 
      successful than previously thought.
CI  - (c) 2020 The Authors. British Journal of Surgery published by John Wiley & Sons Ltd 
      on behalf of BJS Society Ltd.
FAU - van Beek, D J
AU  - van Beek DJ
AUID- ORCID: 0000-0001-7834-8128
AD  - Department of Endocrine Surgical Oncology, Utrecht, the Netherlands.
FAU - Nell, S
AU  - Nell S
AUID- ORCID: 0000-0001-7333-566X
AD  - Department of Endocrine Surgical Oncology, Utrecht, the Netherlands.
AD  - Department of Endocrine Oncology, Utrecht, the Netherlands.
FAU - Verkooijen, H M
AU  - Verkooijen HM
AUID- ORCID: 0000-0001-9480-1623
AD  - Imaging Division, University Medical Centre Utrecht, Utrecht, the Netherlands.
FAU - Borel Rinkes, I H M
AU  - Borel Rinkes IHM
AUID- ORCID: 0000-0003-2122-7207
AD  - Department of Endocrine Surgical Oncology, Utrecht, the Netherlands.
FAU - Valk, G D
AU  - Valk GD
AUID- ORCID: 0000-0001-5841-8344
AD  - Department of Endocrine Oncology, Utrecht, the Netherlands.
CN  - (on behalf of the DutchMEN study group)
FAU - Vriens, M R
AU  - Vriens MR
AD  - Department of Endocrine Surgical Oncology, Utrecht, the Netherlands.
CN  - International MEN1 Insulinoma Study Group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20200430
PL  - England
TA  - Br J Surg
JT  - The British journal of surgery
JID - 0372553
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - Clinical Decision-Making
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypoglycemia/epidemiology/etiology
MH  - Insulinoma/complications/*surgery
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/complications/*surgery
MH  - Neoplasm Recurrence, Local/epidemiology
MH  - *Pancreatectomy
MH  - Pancreatic Neoplasms/complications/*surgery
MH  - Postoperative Complications/epidemiology
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC7540387
FIR - Goudet, P
IR  - Goudet P
FIR - Vella, A
IR  - Vella A
FIR - Donegan, D
IR  - Donegan D
FIR - Bartsch, D K
IR  - Bartsch DK
FIR - Manoharan, J
IR  - Manoharan J
FIR - Perrier, N D
IR  - Perrier ND
FIR - Christakis, I
IR  - Christakis I
FIR - Brandi, M L
IR  - Brandi ML
FIR - Zarnegar, R
IR  - Zarnegar R
FIR - Postma, E L
IR  - Postma EL
FIR - Kebebew, E
IR  - Kebebew E
FIR - Nockel, P
IR  - Nockel P
FIR - Brunaud, L
IR  - Brunaud L
FIR - Pasternak, J D
IR  - Pasternak JD
FIR - Kluijfhout, W P
IR  - Kluijfhout WP
FIR - Sturgeon, C
IR  - Sturgeon C
FIR - Giri, S
IR  - Giri S
FIR - Bonsing, B A
IR  - Bonsing BA
FIR - van Eijck, C H
IR  - van Eijck CH
FIR - van Goor, H
IR  - van Goor H
FIR - de Kleine, R H J
IR  - de Kleine RHJ
FIR - van Dijkum, E J Nieveen
IR  - van Dijkum EJN
FIR - Dejong, C H C
IR  - Dejong CHC
EDAT- 2020/05/01 06:00
MHDA- 2021/03/02 06:00
PMCR- 2020/10/07
CRDT- 2020/05/01 06:00
PHST- 2019/12/20 00:00 [received]
PHST- 2020/02/09 00:00 [revised]
PHST- 2020/03/19 00:00 [accepted]
PHST- 2020/05/01 06:00 [pubmed]
PHST- 2021/03/02 06:00 [medline]
PHST- 2020/05/01 06:00 [entrez]
PHST- 2020/10/07 00:00 [pmc-release]
AID - BJS11632 [pii]
AID - 10.1002/bjs.11632 [doi]
PST - ppublish
SO  - Br J Surg. 2020 Oct;107(11):1489-1499. doi: 10.1002/bjs.11632. Epub 2020 Apr 30.