PMID- 32352194
OWN - NLM
STAT- MEDLINE
DCOM- 20210706
LR  - 20240329
IS  - 1742-7843 (Electronic)
IS  - 1742-7835 (Print)
IS  - 1742-7835 (Linking)
VI  - 127
IP  - 4
DP  - 2020 Oct
TI  - DNA methylation level in blood and relations to breast cancer, risk factors and 
      environmental exposure in Greenlandic Inuit women.
PG  - 338-350
LID - 10.1111/bcpt.13424 [doi]
AB  - Several studies have found aberrant DNA methylation levels in breast cancer 
      cases, but factors influencing DNA methylation patterns and the mechanisms are 
      not well understood. This case-control study evaluated blood methylation level of 
      two repetitive elements and selected breast cancer-related genes in relation to 
      breast cancer risk, and the associations with serum level of persistent organic 
      pollutants (POPs) and breast cancer risk factors in Greenlandic Inuit. DNA 
      methylation was determined using bisulphite pyrosequencing in blood from 74 
      breast cancer cases and 80 controls. Using first tertile as reference, the 
      following was observed. Positive associations for ATM in second tertile (OR: 
      2.33, 95% CI: 1.04; 5.23) and ESR2 in third tertile (OR: 2.22, 95% CI: 0.97; 
      5.05) suggest an increased breast cancer risk with high DNA methylation. LINE-1 
      methylation was lower in cases than controls. In third tertile (OR: 0.42, 95% CI: 
      0.18; 0.98), associations suggest in accordance with the literature an increased 
      risk of breast cancer with LINE-1 hypomethylation. Among controls, significant 
      associations between methylation levels and serum level of POPs and breast cancer 
      risk factors (age, body mass index, cotinine level) were found. Thus, breast 
      cancer risk factors and POPs may alter the risk through changes in methylation 
      levels; further studies are needed to elucidate the mechanisms.
CI  - (c) 2020 The Authors. Basic & Clinical Pharmacology & Toxicology published by John 
      Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT 
      (former Nordic Pharmacological Society).
FAU - Wielsoe, Maria
AU  - Wielsoe M
AD  - Department of Public Health, Centre for Arctic Health & Molecular Epidemiology, 
      Aarhus University, Aarhus C, Denmark.
FAU - Tarantini, Letizia
AU  - Tarantini L
AD  - EPIGET - Epidemiology, Epigenetics and Toxicology Laboratory, Department of 
      Clinical Sciences and Community Health, Universita degli Studi di Milano, Milan, 
      Italy.
FAU - Bollati, Valentina
AU  - Bollati V
AD  - EPIGET - Epidemiology, Epigenetics and Toxicology Laboratory, Department of 
      Clinical Sciences and Community Health, Universita degli Studi di Milano, Milan, 
      Italy.
FAU - Long, Manhai
AU  - Long M
AD  - Department of Public Health, Centre for Arctic Health & Molecular Epidemiology, 
      Aarhus University, Aarhus C, Denmark.
FAU - Bonefeld-Jorgensen, Eva Cecilie
AU  - Bonefeld-Jorgensen EC
AUID- ORCID: 0000-0001-5043-5553
AD  - Department of Public Health, Centre for Arctic Health & Molecular Epidemiology, 
      Aarhus University, Aarhus C, Denmark.
AD  - Greenland Center for Health Research, University of Greenland, Nuuk, Greenland.
LA  - eng
GR  - Else og Mogens Wedell-Wedellsborgs Fond/
GR  - Fabrikant Einar Willumsens Mindelegat/
GR  - 09/International Polar Year Committee/
GR  - -/International Polar Year Committee/
GR  - 064624/International Polar Year Committee/
GR  - 2015/Commission for Scientific Research in Greenland/
GR  - -/Commission for Scientific Research in Greenland/
GR  - 111,969/Commission for Scientific Research in Greenland/
GR  - Department for Health and Infrastructure (Greenland Self-government, Nuuk), 
      Aarhus University/
GR  - MST-112-00243/Danish Environmental Agency (Miljostyrelsen)/
PT  - Journal Article
DEP - 20200518
PL  - England
TA  - Basic Clin Pharmacol Toxicol
JT  - Basic & clinical pharmacology & toxicology
JID - 101208422
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/*genetics
MH  - Case-Control Studies
MH  - DNA/*drug effects
MH  - DNA Methylation
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Greenland
MH  - Humans
MH  - Inuit
MH  - Middle Aged
MH  - Persistent Organic Pollutants/*adverse effects/blood
MH  - Risk Factors
PMC - PMC7540549
OTO - NOTNLM
OT  - arctic inuit
OT  - circadian genes
OT  - persistent organic pollutants
OT  - repetitive elements
OT  - tumour suppressor genes
COIS- The authors have nothing to disclose.
EDAT- 2020/05/01 06:00
MHDA- 2021/07/07 06:00
PMCR- 2020/10/07
CRDT- 2020/05/01 06:00
PHST- 2019/12/17 00:00 [received]
PHST- 2020/03/23 00:00 [revised]
PHST- 2020/04/24 00:00 [accepted]
PHST- 2020/05/01 06:00 [pubmed]
PHST- 2021/07/07 06:00 [medline]
PHST- 2020/05/01 06:00 [entrez]
PHST- 2020/10/07 00:00 [pmc-release]
AID - BCPT13424 [pii]
AID - 10.1111/bcpt.13424 [doi]
PST - ppublish
SO  - Basic Clin Pharmacol Toxicol. 2020 Oct;127(4):338-350. doi: 10.1111/bcpt.13424. 
      Epub 2020 May 18.