PMID- 32354573
OWN - NLM
STAT- MEDLINE
DCOM- 20210122
LR  - 20210122
IS  - 1768-3122 (Electronic)
IS  - 0248-8663 (Linking)
VI  - 41
IP  - 8
DP  - 2020 Aug
TI  - [Illnesses unrelated to systemic sclerosis (IUSS) diagnosed throughout the 
      patient's follow-up in a referral center: A cohort of 200 patients].
PG  - 517-522
LID - S0248-8663(20)30103-X [pii]
LID - 10.1016/j.revmed.2020.03.001 [doi]
AB  - INTRODUCTION: Our work aimed to investigate the illnesses unrelated to systemic 
      sclerosis (IUSS), diagnosed among patients with systemic sclerosis (SSc) 
      throughout their follow-up in a referral tertiary care center. METHODS: All the 
      patients with SSc followed in the Internal Medicine Department of the University 
      Hospital between October, 2014 and December, 2015, were included. We specifically 
      reviewed the medical records of the patients who exhibited IUSS, defined as an 
      illness that could not be considered as a typical clinical manifestation or as a 
      usual complication of the disease. RESULTS: Two hundred patients were included, 
      and 38 IUSS were diagnosed among 31 SSc patients, over a 4 years median follow-up 
      period. These diagnoses included vascular diseases (26%), heart diseases (21%), 
      neoplasia (8%), infectious diseases (6%), autoimmune diseases (5%), 
      endocrinopathies (5%), and others (24%). The median follow-up time before IUSS 
      diagnosis was two years. Seventeen (45%) of these diagnoses were considered in 
      patients showing suggestive clinical signs. A specific therapy was delivered in 
      25 cases (66%). Group comparisons revealed that dyslipidemia was more frequent in 
      patients with IUSS (OR = 2.6 [1.1-1.5]; p = 0.014), while no differences were 
      found for the other characteristics. Especially, no association between 
      auto-antibodies specificity and the occurrence of IUSS was found. CONCLUSION: 
      This study focused on IUSS in SSc patients and highlights the need for a 
      polyvalent clinical approach all along the follow up of SSc patients.
CI  - Copyright (c) 2020. Published by Elsevier Masson SAS.
FAU - Lepart, C
AU  - Lepart C
AD  - Service de Medecine Interne, CHU Hopital Sud, Universite Rennes 1, Rennes, 
      France.
FAU - Ardois, S
AU  - Ardois S
AD  - Service de Medecine Interne, CHU Hopital Sud, Universite Rennes 1, Rennes, 
      France.
FAU - Bismut, M
AU  - Bismut M
AD  - Service de Medecine Interne, CHU Hopital Sud, Universite Rennes 1, Rennes, 
      France.
FAU - Ballerie, A
AU  - Ballerie A
AD  - Service de Medecine Interne, CHU Hopital Sud, Universite Rennes 1, Rennes, 
      France; Inserm, EHESP, Irset (Institut de recherche en sante, environnement et 
      travail) - UMR_S 1085, F-35000 Rennes, France.
FAU - Cazalets, C
AU  - Cazalets C
AD  - Service de Medecine Interne, CHU Hopital Sud, Universite Rennes 1, Rennes, 
      France.
FAU - Coiffier, G
AU  - Coiffier G
AD  - Service de Rhumatologie, Universite Rennes 1, CHU Hopital Sud, 16, bd de Bulgarie 
      35200 Rennes, France; 4 UMR INSERM U 1241, Universite Rennes 1, Rennes, France.
FAU - Jego, P
AU  - Jego P
AD  - Service de Medecine Interne, CHU Hopital Sud, Universite Rennes 1, Rennes, 
      France; Inserm, EHESP, Irset (Institut de recherche en sante, environnement et 
      travail) - UMR_S 1085, F-35000 Rennes, France.
FAU - Belhomme, N
AU  - Belhomme N
AD  - Service de Medecine Interne, CHU Hopital Sud, Universite Rennes 1, Rennes, 
      France. Electronic address: nicolas.belhomme@chu-rennes.fr.
FAU - Lescoat, A
AU  - Lescoat A
AD  - Service de Medecine Interne, CHU Hopital Sud, Universite Rennes 1, Rennes, 
      France; Inserm, EHESP, Irset (Institut de recherche en sante, environnement et 
      travail) - UMR_S 1085, F-35000 Rennes, France.
LA  - fre
PT  - Journal Article
PT  - Observational Study
TT  - Affections non-directement attribuables a la sclerodermie systemique (ANDAS) 
      diagnostiquees au cours du suivi dans un centre de competence: a propos d'une 
      cohorte de 200 patients.
DEP - 20200428
PL  - France
TA  - Rev Med Interne
JT  - La Revue de medecine interne
JID - 8101383
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Comorbidity
MH  - Female
MH  - Follow-Up Studies
MH  - France/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Physiologic/statistics & numerical data
MH  - Retrospective Studies
MH  - Scleroderma, Systemic/diagnosis/*epidemiology
MH  - Tertiary Care Centers
OTO - NOTNLM
OT  - Affection non-directement attribuable a la sclerodermie systemique
OT  - Diagnosis
OT  - Diagnostic
OT  - Follow-up
OT  - Illnesses unrelated to systemic sclerosis
OT  - Sclerodermie systemique
OT  - Suivi
OT  - Systemic sclerosis
EDAT- 2020/05/02 06:00
MHDA- 2021/01/23 06:00
CRDT- 2020/05/02 06:00
PHST- 2019/07/23 00:00 [received]
PHST- 2020/01/22 00:00 [revised]
PHST- 2020/03/06 00:00 [accepted]
PHST- 2020/05/02 06:00 [pubmed]
PHST- 2021/01/23 06:00 [medline]
PHST- 2020/05/02 06:00 [entrez]
AID - S0248-8663(20)30103-X [pii]
AID - 10.1016/j.revmed.2020.03.001 [doi]
PST - ppublish
SO  - Rev Med Interne. 2020 Aug;41(8):517-522. doi: 10.1016/j.revmed.2020.03.001. Epub 
      2020 Apr 28.