PMID- 32354665
OWN - NLM
STAT- MEDLINE
DCOM- 20210526
LR  - 20210526
IS  - 1769-7131 (Electronic)
IS  - 0987-7053 (Linking)
VI  - 50
IP  - 3
DP  - 2020 Jul
TI  - Cortical visuomotor interactions in Freezing of Gait: A TMS approach.
PG  - 205-212
LID - S0987-7053(20)30049-6 [pii]
LID - 10.1016/j.neucli.2020.04.001 [doi]
AB  - OBJECTIVES: Altered cortical visuomotor integration has been involved in the 
      pathophysiology of freezing of gait (FoG) in parkinsonism. The aim of this study 
      was to assess the connections between the primary visual (V1) and motor (M1) 
      areas with a paired-pulse, twin-coil transcranial magnetic stimulation (TMS) 
      technique in patients with FoG. METHODS: Twelve Parkinson's disease (PD) patients 
      suffering from levodopa-responsive-FoG (off-FoG) were compared with 12 PD 
      patients without FoG and 12 healthy subjects of similar age/sex. In the "off" 
      condition, visuomotor connections (VMCs) were assessed bilaterally. A 
      conditioning stimulus over the V1 phosphene hotspot was followed at interstimulus 
      intervals (ISIs) of 18 and 40ms by a test stimulus over M1, to elicit motor 
      evoked potentials (MEPs) in the contralateral first dorsal interosseous muscle. 
      RESULTS: Significant (P<0.01), bilateral effects due to VMCs were detected in all 
      three groups, consisting of a MEP suppression at ISI 18 and 40ms. However, in PD 
      patients with FoG, the MEP suppression was significantly (P<0.05) enhanced, both 
      at ISI 18-40ms, in comparison with the other two groups. The phenomenon was 
      limited to the right hemisphere. CONCLUSIONS: PD patients with FoG showed an 
      excessive inhibitory response of the right M1 to inputs travelling from V1 at 
      given ISIs. Right-sided alterations of the cortical visuomotor integration may 
      contribute to the pathophysiology of FoG.
CI  - Copyright (c) 2020 Elsevier Masson SAS. All rights reserved.
FAU - Strigaro, Gionata
AU  - Strigaro G
AD  - Department of Translational Medicine, Section of Neurology, University of 
      Piemonte Orientale and "Maggiore della Carita" University Hospital, Novara, 
      Italy. Electronic address: gionata.strigaro@gmail.com.
FAU - Barbero, Paolo
AU  - Barbero P
AD  - Department of Translational Medicine, Section of Neurology, University of 
      Piemonte Orientale and "Maggiore della Carita" University Hospital, Novara, 
      Italy.
FAU - Pizzamiglio, Chiara
AU  - Pizzamiglio C
AD  - Department of Translational Medicine, Section of Neurology, University of 
      Piemonte Orientale and "Maggiore della Carita" University Hospital, Novara, 
      Italy.
FAU - Magistrelli, Luca
AU  - Magistrelli L
AD  - Department of Translational Medicine, Section of Neurology, University of 
      Piemonte Orientale and "Maggiore della Carita" University Hospital, Novara, 
      Italy.
FAU - Gori, Benedetta
AU  - Gori B
AD  - Department of Translational Medicine, Section of Neurology, University of 
      Piemonte Orientale and "Maggiore della Carita" University Hospital, Novara, 
      Italy.
FAU - Comi, Cristoforo
AU  - Comi C
AD  - Department of Translational Medicine, Section of Neurology, University of 
      Piemonte Orientale and "Maggiore della Carita" University Hospital, Novara, 
      Italy.
FAU - Varrasi, Claudia
AU  - Varrasi C
AD  - Department of Translational Medicine, Section of Neurology, University of 
      Piemonte Orientale and "Maggiore della Carita" University Hospital, Novara, 
      Italy.
FAU - Cantello, Roberto
AU  - Cantello R
AD  - Department of Translational Medicine, Section of Neurology, University of 
      Piemonte Orientale and "Maggiore della Carita" University Hospital, Novara, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20200427
PL  - France
TA  - Neurophysiol Clin
JT  - Neurophysiologie clinique = Clinical neurophysiology
JID - 8804532
SB  - IM
MH  - Aged
MH  - Evoked Potentials, Motor
MH  - Female
MH  - Gait Disorders, Neurologic/etiology/*physiopathology
MH  - Humans
MH  - Male
MH  - Motor Cortex/*physiopathology
MH  - Parkinson Disease/complications/*physiopathology
MH  - Transcranial Magnetic Stimulation
MH  - Visual Cortex/*physiopathology
OTO - NOTNLM
OT  - Freezing of gait
OT  - Motor cortex
OT  - Parkinson's disease
OT  - Transcranial magnetic stimulation
OT  - Visual cortex
OT  - Visuomotor integration
EDAT- 2020/05/02 06:00
MHDA- 2021/05/27 06:00
CRDT- 2020/05/02 06:00
PHST- 2020/02/25 00:00 [received]
PHST- 2020/04/10 00:00 [revised]
PHST- 2020/04/10 00:00 [accepted]
PHST- 2020/05/02 06:00 [pubmed]
PHST- 2021/05/27 06:00 [medline]
PHST- 2020/05/02 06:00 [entrez]
AID - S0987-7053(20)30049-6 [pii]
AID - 10.1016/j.neucli.2020.04.001 [doi]
PST - ppublish
SO  - Neurophysiol Clin. 2020 Jul;50(3):205-212. doi: 10.1016/j.neucli.2020.04.001. 
      Epub 2020 Apr 27.