PMID- 32354674
OWN - NLM
STAT- MEDLINE
DCOM- 20210922
LR  - 20210922
IS  - 1879-0305 (Electronic)
IS  - 1359-6101 (Linking)
VI  - 55
DP  - 2020 Oct
TI  - Multifactorial effects of hyperglycaemia, hyperinsulinemia and inflammation on 
      bone remodelling in type 2 diabetes mellitus.
PG  - 109-118
LID - S1359-6101(20)30050-2 [pii]
LID - 10.1016/j.cytogfr.2020.04.001 [doi]
AB  - Bones undergo continuous cycles of bone remodelling that rely on the balance 
      between bone formation and resorption. This balance allows the bone to adapt to 
      changes in mechanical loads and repair microdamages. However, this balance is 
      susceptible to upset in various conditions, leading to impaired bone remodelling 
      and abnormal bones. This is usually indicated by abnormal bone mineral density 
      (BMD), an indicator of bone strength. Despite this, patients with type 2 diabetes 
      mellitus (T2DM) exhibit normal to high BMD, yet still suffer from an increased 
      risk of fractures. The activity of the bone cells is also altered as indicated by 
      the reduced levels of bone turnover markers in T2DM observed in the circulation. 
      The underlying mechanisms behind these skeletal outcomes in patients with T2DM 
      remain unclear. This review summarises recent findings regarding inflammatory 
      cytokine factors associated with T2DM to understand the mechanisms involved and 
      considers potential therapeutic interventions.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Shahen, V A
AU  - Shahen VA
AD  - Department of Physiology, School of Medical Sciences, Faculty of Medicine and 
      Health, The University of Sydney, Australia.
FAU - Gerbaix, M
AU  - Gerbaix M
AD  - Division of Bone Diseases, Department of Internal Medicine Specialties, Geneva 
      University Hospital & Faculty of Medicine, Geneva, Switzerland.
FAU - Koeppenkastrop, S
AU  - Koeppenkastrop S
AD  - Department of Physiology, School of Medical Sciences, Faculty of Medicine and 
      Health, The University of Sydney, Australia.
FAU - Lim, S F
AU  - Lim SF
AD  - Department of Physiology, School of Medical Sciences, Faculty of Medicine and 
      Health, The University of Sydney, Australia.
FAU - McFarlane, K E
AU  - McFarlane KE
AD  - Department of Physiology, School of Medical Sciences, Faculty of Medicine and 
      Health, The University of Sydney, Australia.
FAU - Nguyen, Amanda N L
AU  - Nguyen ANL
AD  - Department of Physiology, School of Medical Sciences, Faculty of Medicine and 
      Health, The University of Sydney, Australia.
FAU - Peng, X Y
AU  - Peng XY
AD  - Department of Physiology, School of Medical Sciences, Faculty of Medicine and 
      Health, The University of Sydney, Australia.
FAU - Weiss, N B
AU  - Weiss NB
AD  - Department of Physiology, School of Medical Sciences, Faculty of Medicine and 
      Health, The University of Sydney, Australia.
FAU - Brennan-Speranza, T C
AU  - Brennan-Speranza TC
AD  - Department of Physiology, School of Medical Sciences, Faculty of Medicine and 
      Health, The University of Sydney, Australia; School of Public Health, Faculty of 
      Medicine and Health, The University of Sydney, Australia. Electronic address: 
      tara.speranza@sydney.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200417
PL  - England
TA  - Cytokine Growth Factor Rev
JT  - Cytokine & growth factor reviews
JID - 9612306
SB  - IM
MH  - Bone Remodeling
MH  - *Diabetes Mellitus, Type 2/blood
MH  - Humans
MH  - *Hyperglycemia
MH  - *Hyperinsulinism/blood
MH  - *Inflammation/blood
OTO - NOTNLM
OT  - Bone remodelling
OT  - Bones
OT  - Diabetes
OT  - Hyperglycaemia
OT  - Hyperinsulinemia
OT  - Inflammation
EDAT- 2020/05/02 06:00
MHDA- 2021/09/23 06:00
CRDT- 2020/05/02 06:00
PHST- 2020/03/17 00:00 [received]
PHST- 2020/04/08 00:00 [accepted]
PHST- 2020/05/02 06:00 [pubmed]
PHST- 2021/09/23 06:00 [medline]
PHST- 2020/05/02 06:00 [entrez]
AID - S1359-6101(20)30050-2 [pii]
AID - 10.1016/j.cytogfr.2020.04.001 [doi]
PST - ppublish
SO  - Cytokine Growth Factor Rev. 2020 Oct;55:109-118. doi: 
      10.1016/j.cytogfr.2020.04.001. Epub 2020 Apr 17.