PMID- 32354897
OWN - NLM
STAT- MEDLINE
DCOM- 20210212
LR  - 20210212
IS  - 1791-7549 (Electronic)
IS  - 0258-851X (Print)
IS  - 0258-851X (Linking)
VI  - 34
IP  - 3
DP  - 2020 May-Jun
TI  - Dose-volume Histogram Analysis of Knowledge-based Volumetric-modulated Arc 
      Therapy Planning in Postoperative Breast Cancer Irradiation.
PG  - 1095-1101
LID - 10.21873/invivo.11880 [doi]
AB  - BACKGROUND/AIM: We evaluated the dosimetric profiles of manually generated 
      volumetric-modulated arc therapy (VMAT) plans and performance of a commercial 
      knowledge-based planning system (KBP) in treating breast cancer. MATERIALS AND 
      METHODS: We defined the manually generated VMAT plan as the manual plan (MP). 
      Twenty MPs were generated for left-sided breast cancer patients who underwent 
      breast-conserving surgery and used to develop a KBP training set. The other five 
      patients were used for validation. The dosimetric parameters among MPs, 
      tangential irradiation plans (TPs), and KBP-VMAT plans (KBP-Ps) were compared. 
      RESULTS: D(95) and homogeneity of the planning target volume (PTV) were 
      significantly higher and greater in MPs and KBP-Ps than in TPs. Lung V(20), V(40) 
      The Dmean for the left anterior descending artery was lower in MPs and KBP-Ps 
      than in TPs. KBP could save time in generating VMAT plans. CONCLUSION: MPs and 
      KBP-Ps could ensure higher dose uniformity of PTV than TPs. KBP could faster 
      generate comparable MPs for breast cancer.
CI  - Copyright(c) 2020, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Inoue, Eri
AU  - Inoue E
AD  - Department of Radiation Oncology, Kindai University Faculty of Medicine, Osaka, 
      Japan 1876c1@med.kindai.ac.jp.
FAU - Doi, Hiroshi
AU  - Doi H
AD  - Department of Radiation Oncology, Kindai University Faculty of Medicine, Osaka, 
      Japan.
FAU - Monzen, Hajime
AU  - Monzen H
AD  - Department of Medical Physics, Graduate School of Medical Sciences, Kindai 
      University, Osaka, Japan.
FAU - Tamura, Mikoto
AU  - Tamura M
AD  - Department of Medical Physics, Graduate School of Medical Sciences, Kindai 
      University, Osaka, Japan.
FAU - Inada, Masahiro
AU  - Inada M
AD  - Department of Radiation Oncology, Kindai University Faculty of Medicine, Osaka, 
      Japan.
FAU - Ishikawa, Kazuki
AU  - Ishikawa K
AD  - Department of Radiation Oncology, Kindai University Faculty of Medicine, Osaka, 
      Japan.
FAU - Nakamatsu, Kiyoshi
AU  - Nakamatsu K
AD  - Department of Radiation Oncology, Kindai University Faculty of Medicine, Osaka, 
      Japan.
FAU - Nishimura, Yasumasa
AU  - Nishimura Y
AD  - Department of Radiation Oncology, Kindai University Faculty of Medicine, Osaka, 
      Japan.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Algorithms
MH  - Breast Neoplasms/diagnosis/*radiotherapy
MH  - Disease Management
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Postoperative Care
MH  - *Radiotherapy Dosage
MH  - *Radiotherapy Planning, Computer-Assisted
MH  - *Radiotherapy, Intensity-Modulated/methods/standards
MH  - Tumor Burden
PMC - PMC7279853
OTO - NOTNLM
OT  - Volumetric-modulated arc therapy
OT  - breast cancer
OT  - intensity-modulated radiation therapy
OT  - knowledge-based planning
COIS- The Authors declare that no conflicts of interest exist regarding this study.
EDAT- 2020/05/02 06:00
MHDA- 2021/02/13 06:00
PMCR- 2020/05/03
CRDT- 2020/05/02 06:00
PHST- 2020/01/22 00:00 [received]
PHST- 2020/02/04 00:00 [revised]
PHST- 2020/02/10 00:00 [accepted]
PHST- 2020/05/02 06:00 [entrez]
PHST- 2020/05/02 06:00 [pubmed]
PHST- 2021/02/13 06:00 [medline]
PHST- 2020/05/03 00:00 [pmc-release]
AID - 34/3/1095 [pii]
AID - 10.21873/invivo.11880 [doi]
PST - ppublish
SO  - In Vivo. 2020 May-Jun;34(3):1095-1101. doi: 10.21873/invivo.11880.