PMID- 32355676
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 2304-3881 (Print)
IS  - 2304-389X (Electronic)
IS  - 2304-3881 (Linking)
VI  - 9
IP  - 2
DP  - 2020 Apr
TI  - Is there any correlation between liver graft regeneration and recipient's 
      pretransplant skeletal muscle mass?-a study in extended left lobe graft 
      living-donor liver transplantation.
PG  - 183-194
LID - 10.21037/hbsn.2019.11.08 [doi]
AB  - BACKGROUND: The end-stage liver disease causes a metabolic dysfunction whose most 
      prominent clinical feature is the loss of skeletal muscle mass (SMM). In 
      living-donor liver transplantation (LDLT), liver graft regeneration (GR) 
      represents a crucial process to normalize the portal hypertension and to meet the 
      metabolic demand of the recipient. Limited data are available on the correlation 
      between pre-LDLT low SMM and GR. METHODS: Retrospective study on a cohort of 106 
      LDLT patients receiving an extended left liver lobe graft. The skeletal muscle 
      index (SMI) at L3 level was used for muscle mass measurement, and the recommended 
      cut-off values of the Japanese Society of Hepatology guidelines were used as 
      criteria for defining low muscularity. GR was evaluated as rate of volume 
      increase at 1 month post-LT [graft regeneration rate (GRR)]. RESULTS: The median 
      GRR at 1 month post-LT was 91% (IQR, 65-128%) and a significant correlation with 
      graft volume-to-recipient standard liver volume ratio (GV/SLV) (rho -0.467, 
      P<0.001), graft-to-recipient weight ratio (GRWR) (rho -0.414, P<0.001), donor age 
      (rho -0.306, P=0.001), 1 month post-LT cholinesterase serum levels (rho 0.397, 
      P=0.002) and pre-LT low muscularity [absent vs. present GRR 97.5% (73.1-130%) vs. 
      83.5% (45.2-110.9%), P=0.041] was noted. Moreover in male recipients, but not in 
      women, it was shown a direct correlation with pre-LT SMI (rho 0.352, P=0.020) and 
      inverse correlation with 1 month post-LT SMI variation (rho -0.301, P=0.049). A 
      low GRR was identified as an independent prognostic factor for recipient overall 
      survival (HR 6.045, P<0.001). CONCLUSIONS: Additionally to the hemodynamic 
      factors of portal circulation and the quality of the graft, the metabolic status 
      of the recipients has a significant role in the GR process. A pre-LT low SMM is 
      associated with impaired GRR and this negative impact is more evident in male 
      recipients.
CI  - 2020 Hepatobiliary Surgery and Nutrition. All rights reserved.
FAU - Pravisani, Riccardo
AU  - Pravisani R
AD  - Department of Surgery, Nagasaki University Graduate School of Biomedical 
      Sciences, Nagasaki, Japan.
AD  - Liver-Kidney Transplant Unit, Department of Medicine, University of Udine, Udine, 
      Italy.
FAU - Soyama, Akihiko
AU  - Soyama A
AD  - Department of Surgery, Nagasaki University Graduate School of Biomedical 
      Sciences, Nagasaki, Japan.
FAU - Ono, Shinichiro
AU  - Ono S
AD  - Department of Surgery, Nagasaki University Graduate School of Biomedical 
      Sciences, Nagasaki, Japan.
FAU - Baccarani, Umberto
AU  - Baccarani U
AD  - Liver-Kidney Transplant Unit, Department of Medicine, University of Udine, Udine, 
      Italy.
FAU - Isola, Miriam
AU  - Isola M
AD  - Division of Medical Statistic, Department of Medicine, University of Udine, 
      Udine, Italy.
FAU - Takatsuki, Mitsuhisa
AU  - Takatsuki M
AD  - Department of Surgery, Nagasaki University Graduate School of Biomedical 
      Sciences, Nagasaki, Japan.
FAU - Hidaka, Masaaki
AU  - Hidaka M
AD  - Department of Surgery, Nagasaki University Graduate School of Biomedical 
      Sciences, Nagasaki, Japan.
FAU - Adachi, Tomohiko
AU  - Adachi T
AD  - Department of Surgery, Nagasaki University Graduate School of Biomedical 
      Sciences, Nagasaki, Japan.
FAU - Hara, Takanobu
AU  - Hara T
AD  - Department of Surgery, Nagasaki University Graduate School of Biomedical 
      Sciences, Nagasaki, Japan.
FAU - Hamada, Takashi
AU  - Hamada T
AD  - Department of Surgery, Nagasaki University Graduate School of Biomedical 
      Sciences, Nagasaki, Japan.
FAU - Pecquenard, Florian
AU  - Pecquenard F
AD  - Department of Surgery, Nagasaki University Graduate School of Biomedical 
      Sciences, Nagasaki, Japan.
FAU - Risaliti, Andrea
AU  - Risaliti A
AD  - Liver-Kidney Transplant Unit, Department of Medicine, University of Udine, Udine, 
      Italy.
FAU - Eguchi, Susumu
AU  - Eguchi S
AD  - Department of Surgery, Nagasaki University Graduate School of Biomedical 
      Sciences, Nagasaki, Japan.
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Hepatobiliary Surg Nutr
JT  - Hepatobiliary surgery and nutrition
JID - 101600750
CIN - Hepatobiliary Surg Nutr. 2021 Aug;10(4):564-566. PMID: 34430545
CIN - Hepatobiliary Surg Nutr. 2021 Dec;10(6):881-883. PMID: 35004961
CIN - Hepatobiliary Surg Nutr. 2021 Dec;10(6):884-886. PMID: 35004962
PMC - PMC7188548
OTO - NOTNLM
OT  - Liver regeneration
OT  - living-donor liver transplantation (LDLT)
OT  - malnutrition
OT  - sarcopenia
OT  - skeletal muscle mass index
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/hbsn.2019.11.08). The authors have 
      no conflicts of interest to declare.
EDAT- 2020/05/02 06:00
MHDA- 2020/05/02 06:01
PMCR- 2020/04/01
CRDT- 2020/05/02 06:00
PHST- 2020/05/02 06:00 [entrez]
PHST- 2020/05/02 06:00 [pubmed]
PHST- 2020/05/02 06:01 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - hbsn-09-02-183 [pii]
AID - 10.21037/hbsn.2019.11.08 [doi]
PST - ppublish
SO  - Hepatobiliary Surg Nutr. 2020 Apr;9(2):183-194. doi: 10.21037/hbsn.2019.11.08.