PMID- 32355734
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220830
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 8
IP  - 6
DP  - 2020 Mar
TI  - NUCB2 polymorphisms are associated with an increased risk for type 2 diabetes in 
      the Chinese population.
PG  - 290
LID - 10.21037/atm.2020.03.02 [doi]
LID - 290
AB  - BACKGROUND: The nucleobindin 2 (NUCB2) gene encodes the NUCB2 protein, which 
      plays a critical role in glucose metabolism and diabetes. This study explored the 
      correlation between NUCB2 genetic variants and type 2 diabetes mellitus (T2DM). 
      The study further examined the different NUCB2 variants that confer risk to T2DM 
      in Chinese Han populations. METHODS: This study evaluated the anthropometric and 
      glycemic profiles of 578 T2DM patients and 1,609 healthy controls. Subsequently, 
      we genotyped five single nucleotide polymorphisms (SNPs) (rs10832756, rs1330, 
      rs10766383, rs10832757, and rs11024251) in all the study participants using a 
      Sequenom Mass ARRAY SNP genotyping platform. RESULTS: The distribution of 
      polymorphisms was significantly different between the T2DM patients and healthy 
      controls. Our logistic regression analysis results showed that the five NUCB2 
      SNPs are significantly correlated with the risk for T2DM, especially 
      rs11024251(P=2.97x10(-6)). Interestingly, analysis of male and female 
      sub-populations separately showed that only two of the SNPs (rs10832757 and 
      rs11024251) have significant correlation to T2DM in males [P=0.0244, odds ratio 
      (OR) 1.28 and P=0.0062, OR 1.35, respectively). In females however, we identified 
      four significant SNPs (rs1330, rs10766383, rs10832757, and rs11024251; P<0.05, OR 
      1.31-1.42). Furthermore, we found that rs1330 is associated with body mass index 
      of female subpopulation only (P=0.0174, beta =0.0060). CONCLUSIONS: NUCB2 
      polymorphisms could have a pivotal role in the presence of T2DM. Sex-specific 
      SNPs of NUCB2 could account for the differences in clinical features of T2DM 
      between male and female subpopulations. Nevertheless, our results should be 
      replicated using larger sample sizes, and experimental investigations are needed 
      to elucidate the molecular mechanisms of the associations observed in this study.
CI  - 2020 Annals of Translational Medicine. All rights reserved.
FAU - Li, Xue-Song
AU  - Li XS
AD  - Department of Endocrinology and Metabolism, Minhang Hospital, Fudan University, 
      Shanghai 201199, China.
FAU - Yan, Chen-Yan
AU  - Yan CY
AD  - Department of Molecular Diagnostics, The Core Laboratory in Medical Center of 
      Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, 
      State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University (SJTU) 
      School of Medicine, Shanghai 200011, China.
FAU - Fan, Yu-Juan
AU  - Fan YJ
AD  - Department of Endocrinology and Metabolism, Minhang Hospital, Fudan University, 
      Shanghai 201199, China.
FAU - Yang, Jia-Lin
AU  - Yang JL
AD  - Department of Endocrinology and Metabolism, Minhang Hospital, Fudan University, 
      Shanghai 201199, China.
FAU - Zhao, Shuang-Xia
AU  - Zhao SX
AD  - Department of Molecular Diagnostics, The Core Laboratory in Medical Center of 
      Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, 
      State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University (SJTU) 
      School of Medicine, Shanghai 200011, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC7186676
OTO - NOTNLM
OT  - Type 2 diabetes mellitus (T2DM)
OT  - nesfatin-1
OT  - nucleobindin 2 (NUCB2)
OT  - single nucleotide polymorphisms (SNPs)
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form and declare: The authors have no conflicts of interest to declare.
EDAT- 2020/05/02 06:00
MHDA- 2020/05/02 06:01
PMCR- 2020/03/01
CRDT- 2020/05/02 06:00
PHST- 2020/05/02 06:00 [entrez]
PHST- 2020/05/02 06:00 [pubmed]
PHST- 2020/05/02 06:01 [medline]
PHST- 2020/03/01 00:00 [pmc-release]
AID - atm-08-06-290 [pii]
AID - 10.21037/atm.2020.03.02 [doi]
PST - ppublish
SO  - Ann Transl Med. 2020 Mar;8(6):290. doi: 10.21037/atm.2020.03.02.