PMID- 32356137
OWN - NLM
STAT- MEDLINE
DCOM- 20210707
LR  - 20210707
IS  - 1970-9366 (Electronic)
IS  - 1828-0447 (Linking)
VI  - 16
IP  - 1
DP  - 2021 Jan
TI  - Association between anemia and outcome in patients hospitalized for acute heart 
      failure syndromes: findings from Beijing Acute Heart Failure Registry (Beijing 
      AHF Registry).
PG  - 183-192
LID - 10.1007/s11739-020-02343-x [doi]
AB  - Whether the anemia increases the risk of mortality in patients with acute heart 
      failure (AHF) remains unclear. This study aims to explore the relationship 
      between anemia and outcomes in patients with AHF including subgroup analysis. 
      This study included 3279 patients with hemoglobin available from the Beijing 
      Acute Heart Failure Registry (Beijing AHF Registry) study. The primary endpoint 
      was all-cause mortality in 1 year, and the secondary endpoint was 1-year 
      all-cause events including all-cause death and readmission. Logistic regression 
      models were applied to describe related variables of anemia in patients with AHF. 
      Multivariate Cox proportional hazards models described associations of anemia 
      with clinical outcomes in the overall cohort and subgroups. 45.4% of the patients 
      were found anemic. They were older and had more comorbidities than non-anemic 
      patients. Variables including older age, female, chronic kidney dysfunction 
      (CKD), lower hematocrit, lower albumin, with loop diuretics applied, without 
      beta-blockers, angiotensin-converting enzyme inhibitors /angiotensin receptor 
      blockers (ACEIs/ARBs) and spironolactone applied in the emergency department (ED) 
      were associated with anemia in AHF patients. Anemic patients had higher 1-year 
      mortality (38.4% vs. 27.2%, p < 0.0001) and 1-year events rates (63.2% vs. 56.7%, 
      p < 0.0001). After adjusted for covariates, anemia was associated with the 
      increase of 1-year mortality (hazard ratio [HR] 1.278; 95% confidence interval 
      [CI] 1.114-1.465; p = 0.0005) and 1-year events (HR 1.136; 95% CI 1.025-1.259; 
      p = 0.0154). The severer anemia patients had higher risks both of 1-year 
      mortality and events. In the subgroup analysis, the independent associations of 
      anemia with 1-year mortality were shown in the subgroups including 
      age < 75 years, male, body mass index < 25 kg/m(2) and BMI >/= 25 kg/m(2), New York 
      Heart Association (NYHA) functional class I-II and NYHA functional class III-IV, 
      with and without cardiovascular ischemia, heart rate (HR) < 100 bpm and 
      HR >/= 100 bpm, systolic blood pressure (SBP) < 120 mmHg and SBP >/= 120 mmHg, left 
      ventricular ejection fraction (LVEF) < 40% and LVEF >/= 40%, serum creatinine 
      (Scr) < 133 umol/l, and with diuretics use, with and without beta-blockers use, 
      without ACEIs/ARBs use in the ED. Anemia is associated with older age, female, 
      CKD, volume overload, malnutrition, with loop diuretics, without beta-blockers, 
      ACEIs/ARBs and spironolactone administration, and higher mortality and 
      readmission in AHF. The risk associations are particular significantly obvious in 
      younger, male, overweight, preserved LVEF, lower Scr, with diuretics and 
      beta-blockers, without ACEIs/ARBs administration subgroups.Clinical trial No. 
      ChiCTR-RIC-17014222.
FAU - Ye, Shao-Dong
AU  - Ye SD
AD  - National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of 
      Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng 
      District, Beijing, 100037, China. lilinpumc@sina.com.
FAU - Wang, Si-Jia
AU  - Wang SJ
AD  - National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of 
      Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng 
      District, Beijing, 100037, China.
AD  - Department of Emergency, Beijing Friendship Hospital, Capital Medical University, 
      Beijing, 100050, China.
FAU - Wang, Guo-Gan
AU  - Wang GG
AD  - National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of 
      Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng 
      District, Beijing, 100037, China. wangguoganfuwai@163.com.
FAU - Li, Lin
AU  - Li L
AD  - National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of 
      Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng 
      District, Beijing, 100037, China.
FAU - Huang, Zhi-Wei
AU  - Huang ZW
AD  - National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of 
      Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng 
      District, Beijing, 100037, China.
FAU - Qin, Jian
AU  - Qin J
AD  - Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, 
      100053, China.
FAU - Li, Chun-Sheng
AU  - Li CS
AD  - Department of Emergency, Beijing Chao Yang Hospital, Capital Medical University, 
      Beijing, 100020, China.
FAU - Yu, Xue-Zhong
AU  - Yu XZ
AD  - Department of Emergency, Peking Union Medical College Hospital, Beijing, 100032, 
      China.
FAU - Shen, Hong
AU  - Shen H
AD  - Department of Emergency, Chinese People's Liberation Army General Hospital, 
      Medical School of Chinese People's Liberation Army, Beijing, 100853, China.
FAU - Yang, Li-Pei
AU  - Yang LP
AD  - Department of Emergency, Beijing Friendship Hospital, Capital Medical University, 
      Beijing, 100050, China.
FAU - Fu, Yan
AU  - Fu Y
AD  - Department of Emergency, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, 100730, China.
FAU - Zheng, Ya-An
AU  - Zheng YA
AD  - Department of Emergency, Peking University Third Hospital, Beijing, 100083, 
      China.
FAU - Zhao, Bin
AU  - Zhao B
AD  - Department of Emergency, Beijing Jishuitan Hospital, Beijing, 100035, China.
FAU - Yu, Dong-Min
AU  - Yu DM
AD  - Department of Emergency, Beijing Tiantan Hospital, Capital Medical University, 
      Beijing, 100050, China.
FAU - Qin, Fu-Jun
AU  - Qin FJ
AD  - Department of Emergency, Liangxiang Hospital of Fangshan District, Beijing, 
      102400, China.
FAU - Zhou, De-Gui
AU  - Zhou DG
AD  - Department of Emergency, Shunyi District Hospital, Beijing, 101300, China.
FAU - Li, Ying
AU  - Li Y
AD  - Department of Emergency, People's Hospital of Beijing Daxing District, Beijing, 
      102600, China.
FAU - Liu, Fu-Jun
AU  - Liu FJ
AD  - Department of Emergency, Beijing Luhe Hospital, Capital Medical University, 
      Beijing, 101100, China.
LA  - eng
GR  - No.2009-SHF04/Capital Health Development Research Fund(CN)/
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20200430
PL  - Italy
TA  - Intern Emerg Med
JT  - Internal and emergency medicine
JID - 101263418
SB  - IM
CIN - Intern Emerg Med. 2021 Jan;16(1):167-170. PMID: 32651940
MH  - Aged
MH  - Aged, 80 and over
MH  - Anemia/*complications
MH  - Beijing/epidemiology
MH  - Cause of Death
MH  - Female
MH  - Heart Failure/drug therapy/etiology/*mortality
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Registries
MH  - Syndrome
OTO - NOTNLM
OT  - Acute heart failure
OT  - Anemia
OT  - Mortality
OT  - Prevalence
OT  - Prognosis
EDAT- 2020/05/02 06:00
MHDA- 2021/07/08 06:00
CRDT- 2020/05/02 06:00
PHST- 2019/09/05 00:00 [received]
PHST- 2020/04/11 00:00 [accepted]
PHST- 2020/05/02 06:00 [pubmed]
PHST- 2021/07/08 06:00 [medline]
PHST- 2020/05/02 06:00 [entrez]
AID - 10.1007/s11739-020-02343-x [pii]
AID - 10.1007/s11739-020-02343-x [doi]
PST - ppublish
SO  - Intern Emerg Med. 2021 Jan;16(1):183-192. doi: 10.1007/s11739-020-02343-x. Epub 
      2020 Apr 30.