PMID- 32356550
OWN - NLM
STAT- MEDLINE
DCOM- 20210308
LR  - 20210308
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 11
IP  - 5
DP  - 2020 May 1
TI  - Superior hypoglycemic activity of mulberry lacking monosaccharides is accompanied 
      by better activation of the PI3K/Akt and AMPK signaling pathways.
PG  - 4249-4258
LID - 10.1039/d0fo00427h [doi]
AB  - Mulberry has been used as a functional food to treat type 2 diabetes mellitus 
      (T2DM). However, it contains relatively high levels of fructose and glucose, 
      which are not suitable for excess consumption by diabetic patients. In this study 
      we used microbial fermentation to remove fructose and glucose from mulberry 
      fruit, and then determined the effects on glycemia, the phosphatidylinositol 
      3-hydroxykinase/Akt (PI3K/Akt) and adenosine monophosphate-activated protein 
      kinase (AMPK) signaling pathways and their downstream effectors in T2DM mice. 
      After 5 weeks of administration, fermented mulberry (FM) significantly reduced 
      fasting blood glucose, and also improved insulin sensitivity and glucose 
      tolerance, more effectively than unfermented mulberry (MP). Moreover, compared 
      with MP, FM had a more marked effect on the protein expression of intermediates 
      in the PI3K/Akt and AMPK signaling pathways and their effectors: insulin 
      receptor, phosphorylated Akt (Ser 308), phosphorylated glycogen synthase 
      kinase-3beta (Ser 9), glycogen synthetase, phosphorylated forkhead transcription 
      factor 1 (Ser 256), pyruvate carboxylase, phosphoenolpyruvate carboxykinase, 
      fructose-1, 6-bisphosphatase, glucose-6-phosphatase, lipoprotein lipase, and 
      phosphorylated AMPK (Thr 172), glucose transporter 4 and pyruvate kinase. These 
      findings indicate that mulberry fruit modified to remove fructose and glucose may 
      be more promising than whole mulberry as a treatment for diabetes.
FAU - Long, Xiao-Shan
AU  - Long XS
AD  - Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural 
      Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural 
      Affairs/Guangdong Key Laboratory of Agricultural Products Processing, No. 133 
      Yiheng St., Dongguanzhuang Rd, Tianhe District, Guangzhou 510610, P.R. China. 
      hu.tenggen@foxmail.com.
FAU - Liao, Sen-Tai
AU  - Liao ST
FAU - Wen, Peng
AU  - Wen P
FAU - Zou, Yu-Xiao
AU  - Zou YX
FAU - Liu, Fan
AU  - Liu F
FAU - Shen, Wei-Zhi
AU  - Shen WZ
FAU - Hu, Teng-Gen
AU  - Hu TG
LA  - eng
PT  - Journal Article
DEP - 20200501
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Plant Extracts)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
SB  - IM
MH  - AMP-Activated Protein Kinases/drug effects
MH  - Animals
MH  - Diabetes Mellitus, Type 2/drug therapy
MH  - Disease Models, Animal
MH  - Functional Food
MH  - Humans
MH  - Hypoglycemic Agents/*pharmacology/therapeutic use
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - *Morus
MH  - Phosphatidylinositol 3-Kinases/drug effects
MH  - Phytotherapy
MH  - Plant Extracts/chemistry/*pharmacology/therapeutic use
MH  - Proto-Oncogene Proteins c-akt/drug effects
MH  - Signal Transduction/*drug effects
MH  - Specific Pathogen-Free Organisms
EDAT- 2020/05/02 06:00
MHDA- 2021/03/09 06:00
CRDT- 2020/05/02 06:00
PHST- 2020/05/02 06:00 [pubmed]
PHST- 2021/03/09 06:00 [medline]
PHST- 2020/05/02 06:00 [entrez]
AID - 10.1039/d0fo00427h [doi]
PST - ppublish
SO  - Food Funct. 2020 May 1;11(5):4249-4258. doi: 10.1039/d0fo00427h. Epub 2020 May 1.